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. 1969 Nov;115(3):489–493. doi: 10.1042/bj1150489

Androgen sulphate formation in male and female mice

D A Lewis 1
PMCID: PMC1185128  PMID: 4242857

Abstract

1. After the administration of large doses of androsterone, epiandrosterone, dehydroepiandrosterone and testosterone to mice, females excreted more of the dose conjugated with sulphuric acid than did males. 2. Liver slices from female mice conjugated androgens with sulphuric acid to a greater extent than did slices from males. 3. Sulphotransferase preparations from livers of female rats and mice catalysed the formation of dehydroepiandrosterone sulphate at a faster rate than preparations from livers of the male animals. 4. A possible explanation for the observed sex differences is discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BARRY M. C., EIDINOFF M. L., DOBRINER K., GALLAGHER T. F. The fate of C14 testosterone and C14-progesterone in mice and rats. Endocrinology. 1952 Jun;50(6):587–599. doi: 10.1210/endo-50-6-587. [DOI] [PubMed] [Google Scholar]
  2. DAVIDSON E. A., RILEY J. G. Enzymatic sulfation of chondroitin B. J Biol Chem. 1960 Dec;235:3367–3369. [PubMed] [Google Scholar]
  3. DE MEIO R. H., WIZERKANIUK M., SCHREIBMAN I. Enzymatic system synthesizing sulfuric acid esters of phenols. J Biol Chem. 1955 Mar;213(1):439–443. [PubMed] [Google Scholar]
  4. LEWBART M. L., SCHNEIDER J. J. Enzymatic synthesis of steroid sulfates. J Biol Chem. 1956 Oct;222(2):787–794. [PubMed] [Google Scholar]
  5. Lewis D. A. Androgen sulphate formation in male and female rats. Biochem J. 1968 Jan;106(2):497–501. doi: 10.1042/bj1060497. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Lewis D. A. Sex differences in androgen sulphate formation in rats and mice. Biochem J. 1968 Sep;109(2):12P–13P. doi: 10.1042/bj1090012pb. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Lewis D. A. The metabolism of cis- and trans-indane-1,2-diol. Biochem J. 1966 Jun;99(3):694–702. doi: 10.1042/bj0990694. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Menini E. The indirect analysis of 17-oxosteroid glucosiduronates and sulphates in human urine. Biochem J. 1966 Jun;99(3):747–759. doi: 10.1042/bj0990747. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. NOSE Y., LIPMANN F. Separation of steroid sulfokinases. J Biol Chem. 1958 Dec;233(6):1348–1351. [PubMed] [Google Scholar]
  10. RAO L. G., TAYLOR W. THE METABOLISM OF PROGESTERONE BY ANIMAL TISSUES IN VITRO. SEX AND SPECIES DIFFERENCES IN CONJUGATE FORMATION DURING THE METABOLISM OF (4-14C)PROGESTERONE BY LIVER HOMOGENATES. Biochem J. 1965 Jul;96:172–180. doi: 10.1042/bj0960172. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. ROY A. B. Comparative studies on the liver sulphatases. Biochem J. 1958 Mar;68(3):519–528. doi: 10.1042/bj0680519. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. ROY A. B. The enzymic synthesis of steroid sulphates. Biochem J. 1956 Jun;63(2):294–300. doi: 10.1042/bj0630294. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. ROY A. B. The steroid sulphatase of Patella vulgata. Biochem J. 1956 Jan;62(1):41–50. doi: 10.1042/bj0620041. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. ROY A. The enzymic synthesis of aryl sulphamates. Biochem J. 1960 Jan;74:49–56. doi: 10.1042/bj0740049. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. SIMS P. Metabolism of polycyclic compounds. 19. The metabolism of phenanthrene in rabbits and rats: phenols and sulphuric esters. Biochem J. 1962 Sep;84:558–563. doi: 10.1042/bj0840558. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. TALLAN H. H., BELLA S. T., STEIN W. H., MOORE S. Tyrosine-O-sulfate as a constituent of normal human urine. J Biol Chem. 1955 Dec;217(2):703–708. [PubMed] [Google Scholar]

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