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. 1970 Feb;116(4):663–669. doi: 10.1042/bj1160663

Role of liver-cell potassium ions in secretion of serum albumin and lipoproteins

J D Judah 1, Marion R Nicholls 1
PMCID: PMC1185411  PMID: 4907886

Abstract

1. The incorporation of l-[1-14C]leucine into the proteins of liver slices and into the serum albumin and lipoproteins transported by these slices was investigated. 2. Transport rates were found to be dependent on the K+ content of the slices. 3. The effect of K+ on transport of serum albumin and of serum lipoprotein can be separated from any effect on synthesis by altering K+ concentrations after inhibition of protein synthesis by cycloheximide or puromycin. 4. The effect of low K+ concentrations is reversible. 5. There is linear relationship between the K+ content of the slices and the transport of protein. A simple method is described for maintaining various steady concentrations of K+ in the liver slices. 6. K+ may be replaced by Rb+. Cs+ is partly effective, but NH4+ and Li+ are no more effective than Na+. 7. We found evidence that K+ content rather than the flux rates of K+ or Na+ is important in this effect. 8. These results are probably important in ethionine and carbon tetrachloride poisoning in the rat, and may be significant in liver transplantation.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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