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. 1993 May;18(3):109–112.

Single photon emission computerized tomography in obsessive compulsive disorder: a preliminary study.

B L Adams 1, L B Warneke 1, A J McEwan 1, B A Fraser 1
PMCID: PMC1188506  PMID: 8499426

Abstract

Patterns of cerebral perfusion in patients with obsessive compulsive disorder were evaluated using single photon emission computerized tomography. Eleven patients, who satisfied the DSM-III-R criteria and Research Diagnostic Criteria for the disorder, were evaluated using the distribution of 99m-Tc-HMPAO as a radiotracer. The Yale-Brown Obsessive Compulsive Scale was administered to each patient to assess the severity of their symptoms. The images obtained were evaluated qualitatively and semi-quantitatively by a physician in nuclear medicine who was blind to the patients' diagnoses. Eight of the 11 patients demonstrated asymmetric perfusion of the basal ganglia; the left side showed impaired perfusion in six patients.

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Selected References

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  1. Ananth J., Solyom L., Bryntwick S., Krishnappa U. Chlorimipramine therapy for obsessive-compulsive neurosis. Am J Psychiatry. 1979 May;136(5):700–701. doi: 10.1176/ajp.136.5.700. [DOI] [PubMed] [Google Scholar]
  2. Baxter L. R., Jr, Phelps M. E., Mazziotta J. C., Guze B. H., Schwartz J. M., Selin C. E. Local cerebral glucose metabolic rates in obsessive-compulsive disorder. A comparison with rates in unipolar depression and in normal controls. Arch Gen Psychiatry. 1987 Mar;44(3):211–218. doi: 10.1001/archpsyc.1987.01800150017003. [DOI] [PubMed] [Google Scholar]
  3. Baxter L. R., Jr, Schwartz J. M., Mazziotta J. C., Phelps M. E., Pahl J. J., Guze B. H., Fairbanks L. Cerebral glucose metabolic rates in nondepressed patients with obsessive-compulsive disorder. Am J Psychiatry. 1988 Dec;145(12):1560–1563. doi: 10.1176/ajp.145.12.1560. [DOI] [PubMed] [Google Scholar]
  4. Bland R. C., Orn H., Newman S. C. Lifetime prevalence of psychiatric disorders in Edmonton. Acta Psychiatr Scand Suppl. 1988;338:24–32. doi: 10.1111/j.1600-0447.1988.tb08544.x. [DOI] [PubMed] [Google Scholar]
  5. Hooper H. R., McEwan A. J., Lentle B. C., Kotchon T. L., Hooper P. M. Interactive three-dimensional region of interest analysis of HMPAO SPECT brain studies. J Nucl Med. 1990 Dec;31(12):2046–2051. [PubMed] [Google Scholar]
  6. Husby G., van de Rijn I., Zabriskie J. B., Abdin Z. H., Williams R. C., Jr Antibodies reacting with cytoplasm of subthalamic and caudate nuclei neurons in chorea and acute rheumatic fever. J Exp Med. 1976 Oct 1;144(4):1094–1110. doi: 10.1084/jem.144.4.1094. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Insel T. R., Murphy D. L., Cohen R. M., Alterman I., Kilts C., Linnoila M. Obsessive-compulsive disorder. A double-blind trial of clomipramine and clorgyline. Arch Gen Psychiatry. 1983 Jun;40(6):605–612. doi: 10.1001/archpsyc.1983.04390010015002. [DOI] [PubMed] [Google Scholar]
  8. Jenike M. A., Baer L., Summergrad P., Weilburg J. B., Holland A., Seymour R. Obsessive-compulsive disorder: a double-blind, placebo-controlled trial of clomipramine in 27 patients. Am J Psychiatry. 1989 Oct;146(10):1328–1330. doi: 10.1176/ajp.146.10.1328. [DOI] [PubMed] [Google Scholar]
  9. Laplane D., Baulac M., Widlöcher D., Dubois B. Pure psychic akinesia with bilateral lesions of basal ganglia. J Neurol Neurosurg Psychiatry. 1984 Apr;47(4):377–385. doi: 10.1136/jnnp.47.4.377. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Luxenberg J. S., Swedo S. E., Flament M. F., Friedland R. P., Rapoport J., Rapoport S. I. Neuroanatomical abnormalities in obsessive-compulsive disorder detected with quantitative X-ray computed tomography. Am J Psychiatry. 1988 Sep;145(9):1089–1093. doi: 10.1176/ajp.145.9.1089. [DOI] [PubMed] [Google Scholar]
  11. Mindus P., Nyman H., Rosenquist A., Rydin E., Meyerson B. A. Aspects of personality in patients with anxiety disorders undergoing capsulotomy. Acta Neurochir Suppl (Wien) 1988;44:138–144. doi: 10.1007/978-3-7091-9005-0_27. [DOI] [PubMed] [Google Scholar]
  12. Modell J. G., Mountz J. M., Curtis G. C., Greden J. F. Neurophysiologic dysfunction in basal ganglia/limbic striatal and thalamocortical circuits as a pathogenetic mechanism of obsessive-compulsive disorder. J Neuropsychiatry Clin Neurosci. 1989 Winter;1(1):27–36. doi: 10.1176/jnp.1.1.27. [DOI] [PubMed] [Google Scholar]
  13. Nee L. E., Caine E. D., Polinsky R. J., Eldridge R., Ebert M. H. Gilles de la Tourette syndrome: clinical and family study of 50 cases. Ann Neurol. 1980 Jan;7(1):41–49. doi: 10.1002/ana.410070109. [DOI] [PubMed] [Google Scholar]
  14. Pazos A., Palacios J. M. Quantitative autoradiographic mapping of serotonin receptors in the rat brain. I. Serotonin-1 receptors. Brain Res. 1985 Nov 4;346(2):205–230. doi: 10.1016/0006-8993(85)90856-x. [DOI] [PubMed] [Google Scholar]
  15. Robins L. N., Helzer J. E., Weissman M. M., Orvaschel H., Gruenberg E., Burke J. D., Jr, Regier D. A. Lifetime prevalence of specific psychiatric disorders in three sites. Arch Gen Psychiatry. 1984 Oct;41(10):949–958. doi: 10.1001/archpsyc.1984.01790210031005. [DOI] [PubMed] [Google Scholar]
  16. Sharp P. F., Smith F. W., Gemmell H. G., Lyall D., Evans N. T., Gvozdanovic D., Davidson J., Tyrrell D. A., Pickett R. D., Neirinckx R. D. Technetium-99m HM-PAO stereoisomers as potential agents for imaging regional cerebral blood flow: human volunteer studies. J Nucl Med. 1986 Feb;27(2):171–177. [PubMed] [Google Scholar]
  17. Swedo S. E., Rapoport J. L., Cheslow D. L., Leonard H. L., Ayoub E. M., Hosier D. M., Wald E. R. High prevalence of obsessive-compulsive symptoms in patients with Sydenham's chorea. Am J Psychiatry. 1989 Feb;146(2):246–249. doi: 10.1176/ajp.146.2.246. [DOI] [PubMed] [Google Scholar]

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