Skip to main content
PMC home page
Journal of Psychiatry & Neuroscience : JPN logoLink to Journal of Psychiatry & Neuroscience : JPN
. 1995 Jul;20(4):307–309.

Psychosis in Apert's syndrome with partial agenesis of the corpus callosum.

S Gupta 1, A Popli 1
PMCID: PMC1188707  PMID: 7647085

Abstract

A 19-year-old male with Apert's syndrome developed psychotic symptoms that responded to haloperidol. He was also found to have partial agenesis of the corpus callosum and enlarged lateral ventricles on a head CT scan. The implications of these findings in the context of psychotic symptoms are discussed. There are no previous reports of psychosis in patients with Apert's syndrome.

Full text

PDF
309

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Cohen M. M., Jr, Kreiborg S. The central nervous system in the Apert syndrome. Am J Med Genet. 1990 Jan;35(1):36–45. doi: 10.1002/ajmg.1320350108. [DOI] [PubMed] [Google Scholar]
  2. Cohen M. M., Jr Selected clinical research involving the central nervous system. J Craniofac Genet Dev Biol. 1990;10(2):215–238. [PubMed] [Google Scholar]
  3. Cummings J. L. Organic psychosis. Psychosomatics. 1988 Winter;29(1):16–26. doi: 10.1016/S0033-3182(88)72418-4. [DOI] [PubMed] [Google Scholar]
  4. David A. S., Wacharasindhu A., Lishman W. A. Severe psychiatric disturbance and abnormalities of the corpus callosum: review and case series. J Neurol Neurosurg Psychiatry. 1993 Jan;56(1):85–93. doi: 10.1136/jnnp.56.1.85. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Degreef G., Bogerts B., Falkai P., Greve B., Lantos G., Ashtari M., Lieberman J. Increased prevalence of the cavum septum pellucidum in magnetic resonance scans and post-mortem brains of schizophrenic patients. Psychiatry Res. 1992 May;45(1):1–13. doi: 10.1016/0925-4927(92)90009-s. [DOI] [PubMed] [Google Scholar]
  6. Heath R. G., Franklin D. E., Shraberg D. Gross pathology of the cerebellum in patients diagnosed and treated as functional psychiatric disorders. J Nerv Ment Dis. 1979 Oct;167(10):585–592. doi: 10.1097/00005053-197910000-00001. [DOI] [PubMed] [Google Scholar]
  7. Leuchter A. F., Spar J. E. The late-onset psychoses. Clinical and diagnostic features. J Nerv Ment Dis. 1985 Aug;173(8):488–494. doi: 10.1097/00005053-198508000-00006. [DOI] [PubMed] [Google Scholar]
  8. Miller M. E., Kido D., Horner F. Cavum vergae. Association with neurologic abnormality and diagnosis by magnetic resonance imaging. Arch Neurol. 1986 Aug;43(8):821–823. doi: 10.1001/archneur.1986.00520080061022. [DOI] [PubMed] [Google Scholar]
  9. Swayze V. W., 2nd, Andreasen N. C., Ehrhardt J. C., Yuh W. T., Alliger R. J., Cohen G. A. Developmental abnormalities of the corpus callosum in schizophrenia. Arch Neurol. 1990 Jul;47(7):805–808. doi: 10.1001/archneur.1990.00530070103018. [DOI] [PubMed] [Google Scholar]
  10. Trimble M. R., Cummings J. L. Neuropsychiatric disturbances following brainstem lesions. Br J Psychiatry. 1981 Jan;138:56–59. doi: 10.1192/bjp.138.1.56. [DOI] [PubMed] [Google Scholar]
  11. de León G. A., de León G., Grover W. D., Zaeri N., Alburger P. D. Agenesis of the corpus callosum and limbic malformation in Apert syndrome (type I acrocephalosyndactyly). Arch Neurol. 1987 Sep;44(9):979–982. doi: 10.1001/archneur.1987.00520210073023. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Psychiatry and Neuroscience are provided here courtesy of Canadian Medical Association

RESOURCES