Abstract
The purpose of this study was to examine the relationship between phosphorus magnetic resonance spectroscopy (31P MRS) parameters and left prefrontal volumes in both patients with schizophrenia and healthy subjects. 31P MRS parameters and magnetic resonance imaging (MRI) volumetric data were collected in the left prefrontal region in 10 patients with schizophrenia and 10 healthy subjects of comparable age, handedness, sex, educational level, and parental educational level. No correlations were found between any MRS parameter and grey matter volumes in the combined subjects. Phosphomonoester (PME) and grey matter volumes, however, were both correlated negatively with age. PMEs were found to be decreased, and calculated intracellular magnesium ([Mg2+]intra) was found to be increased in the patients with schizophrenia compared with healthy subjects after adjusting for left prefrontal grey and white matter, total brain volume, and age. These findings suggest that cortical grey and white manner volumes are not directly related to PME and [Mg2+]intra abnormalities in schizophrenia patients.
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- Buchli R., Martin E., Boesiger P., Rumpel H. Developmental changes of phosphorus metabolite concentrations in the human brain: a 31P magnetic resonance spectroscopy study in vivo. Pediatr Res. 1994 Apr;35(4 Pt 1):431–435. [PubMed] [Google Scholar]
- Pettegrew J. W., Keshavan M. S., Panchalingam K., Strychor S., Kaplan D. B., Tretta M. G., Allen M. Alterations in brain high-energy phosphate and membrane phospholipid metabolism in first-episode, drug-naive schizophrenics. A pilot study of the dorsal prefrontal cortex by in vivo phosphorus 31 nuclear magnetic resonance spectroscopy. Arch Gen Psychiatry. 1991 Jun;48(6):563–568. doi: 10.1001/archpsyc.1991.01810300075011. [DOI] [PubMed] [Google Scholar]
- Selemon L. D., Rajkowska G., Goldman-Rakic P. S. Abnormally high neuronal density in the schizophrenic cortex. A morphometric analysis of prefrontal area 9 and occipital area 17. Arch Gen Psychiatry. 1995 Oct;52(10):805–820. doi: 10.1001/archpsyc.1995.03950220015005. [DOI] [PubMed] [Google Scholar]
- Stanley J. A., Williamson P. C., Drost D. J., Carr T. J., Rylett R. J., Malla A., Thompson R. T. An in vivo study of the prefrontal cortex of schizophrenic patients at different stages of illness via phosphorus magnetic resonance spectroscopy. Arch Gen Psychiatry. 1995 May;52(5):399–406. doi: 10.1001/archpsyc.1995.03950170073010. [DOI] [PubMed] [Google Scholar]
- Stanley J. A., Williamson P. C., Drost D. J., Carr T. J., Rylett R. J., Morrison-Stewart S., Thompson R. T. Membrane phospholipid metabolism and schizophrenia: an in vivo 31P-MR spectroscopy study. Schizophr Res. 1994 Oct;13(3):209–215. doi: 10.1016/0920-9964(94)90044-2. [DOI] [PubMed] [Google Scholar]
- Zipursky R. B., Lim K. O., Sullivan E. V., Brown B. W., Pfefferbaum A. Widespread cerebral gray matter volume deficits in schizophrenia. Arch Gen Psychiatry. 1992 Mar;49(3):195–205. doi: 10.1001/archpsyc.1992.01820030027004. [DOI] [PubMed] [Google Scholar]