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. 1998 Oct;62(4):241–244.

Maedi-visna virus and caprine arthritis-encephalitis virus: distinct species or quasispecies and its implications for laboratory diagnosis.

J Pasick 1
PMCID: PMC1189488  PMID: 9798087

Abstract

The lentiviruses responsible for causing maedi-visna or ovine progressive pneumonia in sheep and caprine arthritis-encephalitis in goats have long been considered distinct, albeit related, viral species. Evidence, primarily in the form of nucleic acid sequence data, suggests this distinction may not be as absolute as once thought. These lentiviruses might better be viewed in the context of viral quasispecies whose individual members exhibit varying host range and pathogenic capabilities. Implications for diagnostic testing and control of these diseases are discussed.

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Selected References

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  1. Boshoff C. H., Dungu B., Williams R., Vorster J., Conradie J. D., Verwoerd D. W., York D. F. Detection of Maedi-Visna virus antibodies using a single fusion transmembrane-core p25 recombinant protein ELISA and a modified receiver-operating characteristic analysis to determine cut-off values. J Virol Methods. 1997 Jan;63(1-2):47–56. doi: 10.1016/s0166-0934(96)02114-3. [DOI] [PubMed] [Google Scholar]
  2. Braun M. J., Clements J. E., Gonda M. A. The visna virus genome: evidence for a hypervariable site in the env gene and sequence homology among lentivirus envelope proteins. J Virol. 1987 Dec;61(12):4046–4054. doi: 10.1128/jvi.61.12.4046-4054.1987. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Campbell B. J., Thompson D. R., Williams J. R., Campbell S. G., Avery R. J. Characterization of a New York ovine lentivirus isolate. J Gen Virol. 1993 Feb;74(Pt 2):201–210. doi: 10.1099/0022-1317-74-2-201. [DOI] [PubMed] [Google Scholar]
  4. Cork L. C., Hadlow W. J., Crawford T. B., Gorham J. R., Piper R. C. Infectious leukoencephalomyelitis of young goats. J Infect Dis. 1974 Feb;129(2):134–141. doi: 10.1093/infdis/129.2.134. [DOI] [PubMed] [Google Scholar]
  5. Crawford T. B., Adams D. S., Cheevers W. P., Cork L. C. Chronic arthritis in goats caused by a retrovirus. Science. 1980 Feb 29;207(4434):997–999. doi: 10.1126/science.6153243. [DOI] [PubMed] [Google Scholar]
  6. Dahlberg J. E., Gaskin J. M., Perk K. Morphological and immunological comparison of caprine arthritis encephalitis and ovine progressive pneumonia viruses. J Virol. 1981 Sep;39(3):914–919. doi: 10.1128/jvi.39.3.914-919.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Eigen M., Gardiner W., Schuster P., Winkler-Oswatitsch R. The origin of genetic information. Sci Am. 1981 Apr;244(4):88-92, 96, et passim. doi: 10.1038/scientificamerican0481-88. [DOI] [PubMed] [Google Scholar]
  8. Ellis T. M., Wilcox G. E., Robinson W. F. Antigenic variation of caprine arthritis-encephalitis virus during persistent infection of goats. J Gen Virol. 1987 Dec;68(Pt 12):3145–3152. doi: 10.1099/0022-1317-68-12-3145. [DOI] [PubMed] [Google Scholar]
  9. Gogolewski R. P., Adams D. S., McGuire T. C., Banks K. L., Cheevers W. P. Antigenic cross-reactivity between caprine arthritis-encephalitis, visna and progressive pneumonia viruses involves all virion-associated proteins and glycoproteins. J Gen Virol. 1985 Jun;66(Pt 6):1233–1240. doi: 10.1099/0022-1317-66-6-1233. [DOI] [PubMed] [Google Scholar]
  10. Gudnadóttir M., Pálsson P. A. Transmission of maedi by inoculation of a virus grown in tissue culture from maedi-affected lungs. J Infect Dis. 1967 Feb;117(1):1–6. doi: 10.1093/infdis/117.1.1. [DOI] [PubMed] [Google Scholar]
  11. Karr B. M., Chebloune Y., Leung K., Narayan O. Genetic characterization of two phenotypically distinct North American ovine lentiviruses and their possible origin from caprine arthritis-encephalitis virus. Virology. 1996 Nov 1;225(1):1–10. doi: 10.1006/viro.1996.0569. [DOI] [PubMed] [Google Scholar]
  12. Knowles D. P., Jr, Evermann J. F., Shropshire C., VanderSchalie J., Bradway D., Gezon H. M., Cheevers W. P. Evaluation of agar gel immunodiffusion serology using caprine and ovine lentiviral antigens for detection of antibody to caprine arthritis-encephalitis virus. J Clin Microbiol. 1994 Jan;32(1):243–245. doi: 10.1128/jcm.32.1.243-245.1994. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Kwang J., Cutlip R. Detection of antibodies to ovine lentivirus using a recombinant antigen derived from the env gene. Biochem Biophys Res Commun. 1992 Mar 31;183(3):1040–1046. doi: 10.1016/s0006-291x(05)80295-5. [DOI] [PubMed] [Google Scholar]
  14. Leroux C., Chastang J., Greenland T., Mornex J. F. Genomic heterogeneity of small ruminant lentiviruses: existence of heterogeneous populations in sheep and of the same lentiviral genotypes in sheep and goats. Arch Virol. 1997;142(6):1125–1137. doi: 10.1007/s007050050147. [DOI] [PubMed] [Google Scholar]
  15. Leroux C., Vuillermoz S., Mornex J. F., Greenland T. Genomic heterogeneity in the pol region of ovine lentiviruses obtained from bronchoalveolar cells of infected sheep from France. J Gen Virol. 1995 Jun;76(Pt 6):1533–1537. doi: 10.1099/0022-1317-76-6-1533. [DOI] [PubMed] [Google Scholar]
  16. Marcom K. A., Pearson L. D., Chung C. S., Poulson J. M., DeMartini J. C. Epitope analysis of capsid and matrix proteins of North American ovine lentivirus field isolates. J Clin Microbiol. 1991 Jul;29(7):1472–1479. doi: 10.1128/jcm.29.7.1472-1479.1991. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. McGuire T. C., Brassfield A. L., Davis W. C., Cheevers W. P. Antigenic and structural variation of the p28 core polypeptide of goat and sheep retroviruses. J Gen Virol. 1987 Aug;68(Pt 8):2259–2263. doi: 10.1099/0022-1317-68-8-2259. [DOI] [PubMed] [Google Scholar]
  18. Narayan O., Griffin D. E., Chase J. Antigenic shift of visna virus in persistently infected sheep. Science. 1977 Jul 22;197(4301):376–378. doi: 10.1126/science.195339. [DOI] [PubMed] [Google Scholar]
  19. Oliver R. E., Motha M. X., Phipps J. C., Poole W., Robati G. Experimental infection of caprine arthritis-encephalitis virus in sheep. N Z Vet J. 1988 Jun;36(2):94–95. doi: 10.1080/00480169.1988.35493. [DOI] [PubMed] [Google Scholar]
  20. Pasick J. Use of a recombinant maedi-visna virus protein ELISA for the serologic diagnosis of lentivirus infections in small ruminants. Can J Vet Res. 1998 Oct;62(4):307–310. [PMC free article] [PubMed] [Google Scholar]
  21. Power C., Richardson S., Briscoe M., Pasick J. Evaluation of two recombinant Maedi-visna virus proteins for use in an enzyme-linked immunosorbent assay for the detection of serum antibodies to ovine lentiviruses. Clin Diagn Lab Immunol. 1995 Sep;2(5):631–633. doi: 10.1128/cdli.2.5.631-633.1995. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Querat G., Audoly G., Sonigo P., Vigne R. Nucleotide sequence analysis of SA-OMVV, a visna-related ovine lentivirus: phylogenetic history of lentiviruses. Virology. 1990 Apr;175(2):434–447. doi: 10.1016/0042-6822(90)90428-t. [DOI] [PubMed] [Google Scholar]
  23. Quérat G., Barban V., Sauze N., Filippi P., Vigne R., Russo P., Vitu C. Highly lytic and persistent lentiviruses naturally present in sheep with progressive pneumonia are genetically distinct. J Virol. 1984 Nov;52(2):672–679. doi: 10.1128/jvi.52.2.672-679.1984. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Rosati S., Kwang J., Keen J. E. Genome analysis of North American small ruminant lentiviruses by polymerase chain reaction and restriction enzyme analysis. J Vet Diagn Invest. 1995 Oct;7(4):437–443. doi: 10.1177/104063879500700403. [DOI] [PubMed] [Google Scholar]
  25. Saltarelli M., Querat G., Konings D. A., Vigne R., Clements J. E. Nucleotide sequence and transcriptional analysis of molecular clones of CAEV which generate infectious virus. Virology. 1990 Nov;179(1):347–364. doi: 10.1016/0042-6822(90)90303-9. [DOI] [PubMed] [Google Scholar]
  26. Sargan D. R., Bennet I. D., Cousens C., Roy D. J., Blacklaws B. A., Dalziel R. G., Watt N. J., McConnell I. Nucleotide sequence of EV1, a British isolate of maedi-visna virus. J Gen Virol. 1991 Aug;72(Pt 8):1893–1903. doi: 10.1099/0022-1317-72-8-1893. [DOI] [PubMed] [Google Scholar]
  27. Sonigo P., Alizon M., Staskus K., Klatzmann D., Cole S., Danos O., Retzel E., Tiollais P., Haase A., Wain-Hobson S. Nucleotide sequence of the visna lentivirus: relationship to the AIDS virus. Cell. 1985 Aug;42(1):369–382. doi: 10.1016/s0092-8674(85)80132-x. [DOI] [PubMed] [Google Scholar]
  28. Steinhauer D. A., Holland J. J. Rapid evolution of RNA viruses. Annu Rev Microbiol. 1987;41:409–433. doi: 10.1146/annurev.mi.41.100187.002205. [DOI] [PubMed] [Google Scholar]
  29. Torsteinsdóttir S., Agnarsdóttir G., Matthíasdóttir S., Rafnar B., Andrésdóttir V., Andrésson O. S., Staskus K., Pétursson G., Pálsson P. A., Georgsson G. In vivo and in vitro infection with two different molecular clones of visna virus. Virology. 1997 Mar 17;229(2):370–380. doi: 10.1006/viro.1996.8428. [DOI] [PubMed] [Google Scholar]
  30. Yaniv A., Dahlberg J. E., Tronick S. R., Chiu I. M., Aaronson S. A. Molecular cloning of integrated caprine arthritis-encephalitis virus. Virology. 1985 Sep;145(2):340–345. doi: 10.1016/0042-6822(85)90169-2. [DOI] [PubMed] [Google Scholar]
  31. Zanoni R. G., Nauta I. M., Kuhnert P., Pauli U., Pohl B., Peterhans E. Genomic heterogeneity of small ruminant lentiviruses detected by PCR. Vet Microbiol. 1992 Nov;33(1-4):341–351. doi: 10.1016/0378-1135(92)90061-w. [DOI] [PubMed] [Google Scholar]
  32. Zanoni R. G., Nauta I. M., Pauli U., Peterhans E. Expression in Escherichia coli and sequencing of the coding region for the capsid protein of Dutch maedi-visna virus strain ZZV 1050: application of recombinant protein in enzyme-linked immunosorbent assay for the detection of caprine and ovine lentiviruses. J Clin Microbiol. 1991 Jul;29(7):1290–1294. doi: 10.1128/jcm.29.7.1290-1294.1991. [DOI] [PMC free article] [PubMed] [Google Scholar]
  33. Zink M. C., Johnson L. K. Pathobiology of lentivirus infections of sheep and goats. Virus Res. 1994 May;32(2):139–154. doi: 10.1016/0168-1702(94)90039-6. [DOI] [PubMed] [Google Scholar]

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