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. 1990 Apr;423:485–493. doi: 10.1113/jphysiol.1990.sp018035

The renal and vascular effects of central angiotensin II and atrial natriuretic factor in the anaesthetized rat.

K A Al-Barazanji 1, R J Balment 1
PMCID: PMC1189770  PMID: 2143782

Abstract

1. The interaction between atrial natriuretic factor (ANF) and angiotensin II (Ang II) within the brain to influence renal function and blood pressure was studied in Inactin-anaesthetized male Sprague-Dawley rats. 2. Central infusion of ANF produced a diuresis which was associated with a significant decrease in plasma arginine vasopressin (AVP) level. There was no change in sodium excretion rate over the 80 min of intracerebroventricular ANF infusion and ANF produced no detectable change in mean arterial blood pressure. 3. Central Ang II administration produced a significant decrease in urine flow, which was associated with elevated plasma AVP, an increase in sodium excretion and a rise in mean arterial blood pressure. 4. Combined ANF and Ang II infusion produced an antidiuresis, which was associated with increased plasma AVP concentration. Both the natriuretic and vasopressor actions of central Ang II were abolished when ANF was co-administered. 5. It is concluded that ANF and Ang II interact centrally; ANF antagonizes the pressor and natriuretic effects but not the antidiuretic effects of central Ang II. These data suggest the possibility of distinct and separate sites within the brain through which Ang II influences vasopressin release and renal sodium handling and elevates blood pressure.

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Selected References

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  1. Ashton N., Balment R. J. Blood pressure and renal function in a novel vasopressin-deficient, genetically hypertensive rat strain. J Physiol. 1989 Mar;410:21–34. doi: 10.1113/jphysiol.1989.sp017518. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Balment R. J., Brimble M. J., Forsling M. L., Musabayane C. T. Natriuretic response of the rat to plasma concentrations of arginine vasopressin within the physiological range. J Physiol. 1984 Jul;352:517–526. doi: 10.1113/jphysiol.1984.sp015307. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Brooks V. L., Malvin R. L. Intracerebroventricular infusions of angiotensin II increases sodium excretion. Proc Soc Exp Biol Med. 1982 Apr;169(4):532–537. doi: 10.3181/00379727-169-41385. [DOI] [PubMed] [Google Scholar]
  4. Burnett J. C., Jr, Granger J. P., Opgenorth T. J. Effects of synthetic atrial natriuretic factor on renal function and renin release. Am J Physiol. 1984 Nov;247(5 Pt 2):F863–F866. doi: 10.1152/ajprenal.1984.247.5.F863. [DOI] [PubMed] [Google Scholar]
  5. Cantin M., Genest J. The heart and the atrial natriuretic factor. Endocr Rev. 1985 Spring;6(2):107–127. doi: 10.1210/edrv-6-2-107. [DOI] [PubMed] [Google Scholar]
  6. Chartier L., Schiffrin E., Thibault G., Garcia R. Atrial natriuretic factor inhibits the stimulation of aldosterone secretion by angiotensin II, ACTH and potassium in vitro and angiotensin II-induced steroidogenesis in vivo. Endocrinology. 1984 Nov;115(5):2026–2028. doi: 10.1210/endo-115-5-2026. [DOI] [PubMed] [Google Scholar]
  7. Fitts D. A., Thunhorst R. L., Simpson J. B. Diuresis and reduction of salt appetite by lateral ventricular infusions of atriopeptin II. Brain Res. 1985 Nov 25;348(1):118–124. doi: 10.1016/0006-8993(85)90367-1. [DOI] [PubMed] [Google Scholar]
  8. Forsling M. L., Brimble M. J., Balment R. J. The influence of vasopressin on oxytocin-induced changes in urine flow in the male rat. Acta Endocrinol (Copenh) 1982 Jun;100(2):216–220. doi: 10.1530/acta.0.1000216. [DOI] [PubMed] [Google Scholar]
  9. Halperin E. S., Summy-Long J. Y., Keil L. C., Severs W. B. Aspects of salt/water balance after cerebroventricular infusion of angiotensin II. Brain Res. 1981 Jan 26;205(1):219–221. doi: 10.1016/0006-8993(81)90736-8. [DOI] [PubMed] [Google Scholar]
  10. Hutchinson J. S., Schelling P., Möhring J., Ganten D. Pressor action of centrally perfused angiotensin II in rats with hereditary hypothalamic diabetes insipidus. Endocrinology. 1976 Sep;99(3):819–823. doi: 10.1210/endo-99-3-819. [DOI] [PubMed] [Google Scholar]
  11. Itoh H., Nakao K., Morii N., Yamada T., Shiono S., Sakamoto M., Sugawara A., Saito Y., Katsuura G., Shiomi T. Central action of atrial natriuretic polypeptide on blood pressure in conscious rats. Brain Res Bull. 1986 May;16(5):745–749. doi: 10.1016/0361-9230(86)90147-4. [DOI] [PubMed] [Google Scholar]
  12. Jacobowitz D. M., Skofitsch G., Keiser H. R., Eskay R. L., Zamir N. Evidence for the existence of atrial natriuretic factor-containing neurons in the rat brain. Neuroendocrinology. 1985 Jan;40(1):92–94. doi: 10.1159/000124058. [DOI] [PubMed] [Google Scholar]
  13. Keil L. C., Summy-Long J., Severs W. B. Release of vasopressin by angiotensin II. Endocrinology. 1975 Apr;96(4):1063–1065. doi: 10.1210/endo-96-4-1063. [DOI] [PubMed] [Google Scholar]
  14. Lee J., Feng J. Q., Malvin R. L., Huang B. S., Grekin R. J. Centrally administered atrial natriuretic factor increases renal water excretion. Am J Physiol. 1987 Jun;252(6 Pt 2):F1011–F1015. doi: 10.1152/ajprenal.1987.252.6.F1011. [DOI] [PubMed] [Google Scholar]
  15. Maack T., Camargo M. J., Kleinert H. D., Laragh J. H., Atlas S. A. Atrial natriuretic factor: structure and functional properties. Kidney Int. 1985 Apr;27(4):607–615. doi: 10.1038/ki.1985.54. [DOI] [PubMed] [Google Scholar]
  16. Maack T., Marion D. N., Camargo M. J., Kleinert H. D., Laragh J. H., Vaughan E. D., Jr, Atlas S. A. Effects of auriculin (atrial natriuretic factor) on blood pressure, renal function, and the renin-aldosterone system in dogs. Am J Med. 1984 Dec;77(6):1069–1075. doi: 10.1016/0002-9343(84)90190-6. [DOI] [PubMed] [Google Scholar]
  17. McMurray J., Struthers A. D. Effects of angiotensin II and atrial natriuretic peptide alone and in combination on urinary water and electrolyte excretion in man. Clin Sci (Lond) 1988 Apr;74(4):419–425. doi: 10.1042/cs0740419. [DOI] [PubMed] [Google Scholar]
  18. Nakamura M., Katsuura G., Nakao K., Imura H. Antidipsogenic action of alpha-human atrial natriuretic polypeptide administered intracerebroventricularly in rats. Neurosci Lett. 1985 Jul 4;58(1):1–6. doi: 10.1016/0304-3940(85)90319-2. [DOI] [PubMed] [Google Scholar]
  19. Needleman P. Physiology. The expanding physiological roles of atrial natriuretic factor. Nature. 1986 May 15;321(6067):199–200. doi: 10.1038/321199a0. [DOI] [PubMed] [Google Scholar]
  20. Quirion R., Dalpé M., Dam T. V. Characterization and distribution of receptors for the atrial natriuretic peptides in mammalian brain. Proc Natl Acad Sci U S A. 1986 Jan;83(1):174–178. doi: 10.1073/pnas.83.1.174. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Saavedra J. M., Correa F. M., Plunkett L. M., Israel A., Kurihara M., Shigematsu K. Binding of angiotensin and atrial natriuretic peptide in brain of hypertensive rats. Nature. 1986 Apr 24;320(6064):758–760. doi: 10.1038/320758a0. [DOI] [PubMed] [Google Scholar]
  22. Samson W. K. Atrial natriuretic factor inhibits dehydration and hemorrhage-induced vasopressin release. Neuroendocrinology. 1985 Mar;40(3):277–279. doi: 10.1159/000124085. [DOI] [PubMed] [Google Scholar]
  23. Samson W. K. Dehydration-induced alterations in rat brain vasopressin and atrial natriuretic factor immunoreactivity. Endocrinology. 1985 Sep;117(3):1279–1281. doi: 10.1210/endo-117-3-1279. [DOI] [PubMed] [Google Scholar]
  24. Saper C. B., Standaert D. G., Currie M. G., Schwartz D., Geller D. M., Needleman P. Atriopeptin-immunoreactive neurons in the brain: presence in cardiovascular regulatory areas. Science. 1985 Mar 1;227(4690):1047–1049. doi: 10.1126/science.2858127. [DOI] [PubMed] [Google Scholar]
  25. Shoji M., Kimura T., Matsui K., Ota K., Iitake K., Inoue M., Yasujima M., Abe K., Yoshinaga K. Effects of centrally administered atrial natriuretic peptide on renal functions. Acta Endocrinol (Copenh) 1987 Aug;115(4):433–440. doi: 10.1530/acta.0.1150433. [DOI] [PubMed] [Google Scholar]
  26. Sudoh T., Kangawa K., Minamino N., Matsuo H. A new natriuretic peptide in porcine brain. Nature. 1988 Mar 3;332(6159):78–81. doi: 10.1038/332078a0. [DOI] [PubMed] [Google Scholar]
  27. Yamada T., Nakao K., Morii N., Itoh H., Shiono S., Sakamoto M., Sugawara A., Saito Y., Ohno H., Kanai A. Central effect of atrial natriuretic polypeptide on angiotensin II-stimulated vasopressin secretion in conscious rats. Eur J Pharmacol. 1986 Jun 24;125(3):453–456. doi: 10.1016/0014-2999(86)90802-2. [DOI] [PubMed] [Google Scholar]
  28. de Bold A. J., Borenstein H. B., Veress A. T., Sonnenberg H. A rapid and potent natriuretic response to intravenous injection of atrial myocardial extract in rats. Life Sci. 1981 Jan 5;28(1):89–94. doi: 10.1016/0024-3205(81)90370-2. [DOI] [PubMed] [Google Scholar]
  29. von Schroeder H. P., Nishimura E., McIntosh C. H., Buchan A. M., Wilson N., Ledsome J. R. Autoradiographic localization of binding sites for atrial natriuretic factor. Can J Physiol Pharmacol. 1985 Nov;63(11):1373–1377. doi: 10.1139/y85-226. [DOI] [PubMed] [Google Scholar]

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