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. 1990 Mar;422:523–538. doi: 10.1113/jphysiol.1990.sp017999

Pyloric motor function during emptying of a liquid meal from the stomach in the conscious pig.

P J Treacy 1, G G Jamieson 1, J Dent 1
PMCID: PMC1190147  PMID: 2352191

Abstract

1. In six conscious pigs antral, pyloric and duodenal pressures were recorded with a 5.5 cm sleeve sensor and multiple perfused side holes. The manometric assembly was positioned by dual point transmucosal potential difference measurement. Gastric emptying was measured by drainage of the proximal duodenum through a Thomas cannula. Pressures were correlated with emptying of ingested radiolabelled 5% dextrose. Alteration of emptying was produced by infusion into the more distal duodenum of nutrient and non-nutrient solutions of differing osmolalities. 2. Motor activity of the pylorus and antrum was stimulated by ingestion and modulated by intraduodenal infusion. Duodenal infusion of normal saline was associated with antro-pyloric pressure waves and rapid emptying of the ingested liquid. Duodenal infusion of dextrose, fatty acid, amino acids and hyperosmolar saline was associated with stimulation of isolated pyloric pressure waves, suppression of antral pressure waves and slowing of gastric emptying. 3. The dose-response relationship of these effects was investigated using varying rates of intraduodenal dextrose infusions. The emptying rate of the ingested liquid was inversely related to the rates of delivery of dextrose to the duodenum, directly related to the rate of antro-pyloric pressure waves and inversely related to the rate of isolated pyloric pressure waves. 4. Clearly defined episodes of pulsatile flow produced slightly more than half of the total emptying that occurred. This pulsatile flow was intimately associated in time with antro-pyloric pressure waves. Sequences of isolated pyloric pressure waves were associated with near cessation of emptying. When there were periods of absent pyloric antral pressure waves, flow rates intermediate between the rapid emptying of pulsatile flow during antro-pyloric pressure waves and the near cessation of flow during isolated pyloric pressure waves occurred. 5. The findings suggest a major role for the pylorus in the control of emptying of liquids from the stomach, both as a component of an antro-pyloric peristaltic pump and as a resistor to transpyloric flow during nutrient and hyperosmolar stimulation of duodenal receptors.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Andersson S., Grossman M. I. Profile of pH, pressure, and potential difference at gastroduodenal junction in man. Gastroenterology. 1965 Oct;49(4):364–371. [PubMed] [Google Scholar]
  2. BRINK B. M., SCHLEGEL J. F., CODE C. F. THE PRESSURE PROFILE OF THE GASTRODUODENAL JUNCTIONAL ZONE IN DOGS. Gut. 1965 Apr;6:163–171. doi: 10.1136/gut.6.2.163. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Bertiger G., Reynolds J. C., Ouyang A., Cohen S. Properties of the feline pyloric sphincter in vitro. Gastroenterology. 1987 Jun;92(6):1965–1972. doi: 10.1016/0016-5085(87)90631-7. [DOI] [PubMed] [Google Scholar]
  4. Carlson H. C., Code C. F., Nelson R. A. Motor action of the canine gastroduodenal junction: a cineradiographic, pressure, and electric study. Am J Dig Dis. 1966 Feb;11(2):155–172. doi: 10.1007/BF02239239. [DOI] [PubMed] [Google Scholar]
  5. Collins P. J., Horowitz M., Cook D. J., Harding P. E., Shearman D. J. Gastric emptying in normal subjects--a reproducible technique using a single scintillation camera and computer system. Gut. 1983 Dec;24(12):1117–1125. doi: 10.1136/gut.24.12.1117. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Dent J. A new technique for continuous sphincter pressure measurement. Gastroenterology. 1976 Aug;71(2):263–267. [PubMed] [Google Scholar]
  7. Ehrlein H. J. Motility of the pyloric sphincter studied by the inductograph method in conscious dogs. Am J Physiol. 1988 May;254(5 Pt 1):G650–G657. doi: 10.1152/ajpgi.1988.254.5.G650. [DOI] [PubMed] [Google Scholar]
  8. Fisher R., Cohen S. Physiological characteristics of the human pyloric sphincter. Gastroenterology. 1973 Jan;64(1):67–75. [PubMed] [Google Scholar]
  9. Geall M. G., Code C. F., McIlrath D. C., Summerskill W. H. Measurement of gastrointestinal transmural electric potential difference in man. Gut. 1970 Jan;11(1):34–37. doi: 10.1136/gut.11.1.34. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Heddle R., Dent J., Read N. W., Houghton L. A., Toouli J., Horowitz M., Maddern G. J., Downton J. Antropyloroduodenal motor responses to intraduodenal lipid infusion in healthy volunteers. Am J Physiol. 1988 May;254(5 Pt 1):G671–G679. doi: 10.1152/ajpgi.1988.254.5.G671. [DOI] [PubMed] [Google Scholar]
  11. Heddle R., Dent J., Toouli J., Read N. W. Topography and measurement of pyloric pressure waves and tone in humans. Am J Physiol. 1988 Oct;255(4 Pt 1):G490–G497. doi: 10.1152/ajpgi.1988.255.4.G490. [DOI] [PubMed] [Google Scholar]
  12. Heddle R., Fone D., Dent J., Horowitz M. Stimulation of pyloric motility by intraduodenal dextrose in normal subjects. Gut. 1988 Oct;29(10):1349–1357. doi: 10.1136/gut.29.10.1349. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Isenberg J. I., Csendes A. Effect of octapeptide of cholecystokinin on canine pyloric pressure. Am J Physiol. 1972 Feb;222(2):428–431. doi: 10.1152/ajplegacy.1972.222.2.428. [DOI] [PubMed] [Google Scholar]
  14. Keinke O., Schemann M., Ehrlein H. J. Mechanical factors regulating gastric emptying of viscous nutrient meals in dogs. Q J Exp Physiol. 1984 Oct;69(4):781–795. doi: 10.1113/expphysiol.1984.sp002868. [DOI] [PubMed] [Google Scholar]
  15. King P. M., Adam R. D., Pryde A., McDicken W. N., Heading R. C. Relationships of human antroduodenal motility and transpyloric fluid movement: non-invasive observations with real-time ultrasound. Gut. 1984 Dec;25(12):1384–1391. doi: 10.1136/gut.25.12.1384. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Lewis T. D., Collins S. M., Fox J. E., Daniel E. E. Initiation of duodenal acid-induced motor complexes. Gastroenterology. 1979 Dec;77(6):1217–1224. [PubMed] [Google Scholar]
  17. McIntosh G. H., Pointon A. The Kangaroo Island strain of pig in biomedical research. Aust Vet J. 1981 Apr;57(4):182–185. doi: 10.1111/j.1751-0813.1981.tb00505.x. [DOI] [PubMed] [Google Scholar]
  18. Miller J., Kauffman G., Elashoff J., Ohashi H., Carter D., Meyer J. H. Search for resistances controlling canine gastric emptying of liquid meals. Am J Physiol. 1981 Nov;241(5):G403–G415. doi: 10.1152/ajpgi.1981.241.5.G403. [DOI] [PubMed] [Google Scholar]
  19. Parr N. J., Grime J. S., Baxter J. N., Critchley M., Mackie C. R. Small bowel resistances and the gastroduodenal brake. Gut. 1987 Aug;28(8):950–954. doi: 10.1136/gut.28.8.950. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Phaosawasdi K., Fisher R. S. Hormonal effects on the pylorus. Am J Physiol. 1982 Nov;243(5):G330–G335. doi: 10.1152/ajpgi.1982.243.5.G330. [DOI] [PubMed] [Google Scholar]
  21. Rees W. D., Go V. L., Malagelada J. R. Antroduodenal motor response to solid-liquid and homogenized meals. Gastroenterology. 1979 Jun;76(6):1438–1442. [PubMed] [Google Scholar]
  22. Thompson D. G., Richelson E., Malagelada J. R. Perturbation of upper gastrointestinal function by cold stress. Gut. 1983 Apr;24(4):277–283. doi: 10.1136/gut.24.4.277. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Valenzuela J. E., Defilippi C., Csendes A. Manometric studies on the human pyloric sphincter. Effect of cigarette smoking, metoclopramide, and atropine. Gastroenterology. 1976 Apr;70(4):481–483. [PubMed] [Google Scholar]
  24. White C. M., Poxon V., Alexander-Williams J. A study of motility of normal human gastroduodenal region. Dig Dis Sci. 1981 Jul;26(7):609–617. doi: 10.1007/BF01367673. [DOI] [PubMed] [Google Scholar]
  25. White C. M., Poxon V., Alexander-Williams J. Effects of nutrient liquids on human gastroduodenal motor activity. Gut. 1983 Dec;24(12):1109–1116. doi: 10.1136/gut.24.12.1109. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Wilbur B. G., Kelly K. A., Code C. F. Effect of gastric fundectomy on canine gastric electrical and motor activity. Am J Physiol. 1974 Jun;226(6):1445–1449. doi: 10.1152/ajplegacy.1974.226.6.1445. [DOI] [PubMed] [Google Scholar]
  27. Wilbur B. G., Kelly K. A. Effect of proximal gastric, complete gastric, and truncal vagotomy on canine gastric electric activity, motility, and emptying. Ann Surg. 1973 Sep;178(3):295–303. doi: 10.1097/00000658-197309000-00009. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. Williams N. S., Miller J., Elashoff J., Meyer J. H. Canine resistances to gastric emptying of liquid nutrients after ulcer surgery. Dig Dis Sci. 1986 Mar;31(3):273–280. doi: 10.1007/BF01318119. [DOI] [PubMed] [Google Scholar]

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