Skip to main content
PMC home page
Annals of Surgery logoLink to Annals of Surgery
. 1997 Nov;226(5):582–586. doi: 10.1097/00000658-199711000-00002

A new macroscopic classification predicts prognosis for patient with liver metastases from colorectal cancer.

K Yasui 1, T Hirai 1, T Kato 1, A Torii 1, K Uesaka 1, T Morimoto 1, Y Kodera 1, Y Yamamura 1, T Kito 1, N Hamajima 1
PMCID: PMC1191119  PMID: 9389391

Abstract

OBJECTIVE: The authors defined a new macroscopic classification of liver metastases from colorectal cancer. SUMMARY BACKGROUND DATA: There were different prognostic results after the same operative procedure for liver metastases with similar background factors. METHODS: Eighty-one resected liver metastases were classified into simple nodular (SN) or confluent nodular (CN) types according to the characteristics of the cut surface of the tumor. RESULTS: The 5-year survival rates after hepatectomy were 41.7% for the SN lesions (n = 39) and 23.1% for the CN lesions (n = 42). The difference between the survival curves was statistically significant (p = 0.0307). Multivariate analysis using Cox's proportional hazards model revealed that the macroscopic type (p = 0.023), the tumor diameter (p = 0.0001), and the presence of lymph node metastases (p = 0.0016) were statistically significant independent prognostic factors. CONCLUSION: The new macroscopic classification may be valuable as a prognostic factor reflecting the biologic behavior of liver metastases.

Full text

PDF

Images in this article

584Figure 1.
on p.584

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. August D. A., Sugarbaker P. H., Ottow R. T., Gianola F. J., Schneider P. D. Hepatic resection of colorectal metastases. Influence of clinical factors and adjuvant intraperitoneal 5-fluorouracil via Tenckhoff catheter on survival. Ann Surg. 1985 Feb;201(2):210–218. doi: 10.1097/00000658-198502000-00013. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Butler J., Attiyeh F. F., Daly J. M. Hepatic resection for metastases of the colon and rectum. Surg Gynecol Obstet. 1986 Feb;162(2):109–113. [PubMed] [Google Scholar]
  3. Cady B., McDermott W. V. Major hepatic resection for metachronous metastases from colon cancer. Ann Surg. 1985 Feb;201(2):204–209. doi: 10.1097/00000658-198502000-00012. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Doci R., Gennari L., Bignami P., Montalto F., Morabito A., Bozzetti F. One hundred patients with hepatic metastases from colorectal cancer treated by resection: analysis of prognostic determinants. Br J Surg. 1991 Jul;78(7):797–801. doi: 10.1002/bjs.1800780711. [DOI] [PubMed] [Google Scholar]
  5. Ekberg H., Tranberg K. G., Andersson R., Lundstedt C., Hägerstrand I., Ranstam J., Bengmark S. Pattern of recurrence in liver resection for colorectal secondaries. World J Surg. 1987 Aug;11(4):541–547. doi: 10.1007/BF01655821. [DOI] [PubMed] [Google Scholar]
  6. Fortner J. G., Silva J. S., Golbey R. B., Cox E. B., Maclean B. J. Multivariate analysis of a personal series of 247 consecutive patients with liver metastases from colorectal cancer. I. Treatment by hepatic resection. Ann Surg. 1984 Mar;199(3):306–316. doi: 10.1097/00000658-198403000-00010. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. HEALEY J. E., Jr Clinical anatomic aspects of radical hepatic surgery. J Int Coll Surg. 1954 Nov;22(5 SECT):542–550. [PubMed] [Google Scholar]
  8. Mantel N. Evaluation of survival data and two new rank order statistics arising in its consideration. Cancer Chemother Rep. 1966 Mar;50(3):163–170. [PubMed] [Google Scholar]
  9. Nordlinger B., Quilichini M. A., Parc R., Hannoun L., Delva E., Huguet C. Hepatic resection for colorectal liver metastases. Influence on survival of preoperative factors and surgery for recurrences in 80 patients. Ann Surg. 1987 Mar;205(3):256–263. doi: 10.1097/00000658-198703000-00007. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Pedersen I. K., Burcharth F., Roikjaer O., Baden H. Resection of liver metastases from colorectal cancer. Indications and results. Dis Colon Rectum. 1994 Nov;37(11):1078–1082. doi: 10.1007/BF02049807. [DOI] [PubMed] [Google Scholar]
  11. Resection of the liver for colorectal carcinoma metastases: a multi-institutional study of indications for resection. Registry of Hepatic Metastases. Surgery. 1988 Mar;103(3):278–288. [PMC free article] [PubMed] [Google Scholar]
  12. Rosen C. B., Nagorney D. M., Taswell H. F., Helgeson S. L., Ilstrup D. M., van Heerden J. A., Adson M. A. Perioperative blood transfusion and determinants of survival after liver resection for metastatic colorectal carcinoma. Ann Surg. 1992 Oct;216(4):493–505. doi: 10.1097/00000658-199210000-00012. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Scheele J., Stangl R., Altendorf-Hofmann A. Hepatic metastases from colorectal carcinoma: impact of surgical resection on the natural history. Br J Surg. 1990 Nov;77(11):1241–1246. doi: 10.1002/bjs.1800771115. [DOI] [PubMed] [Google Scholar]
  14. Steele G., Jr, Ravikumar T. S. Resection of hepatic metastases from colorectal cancer. Biologic perspective. Ann Surg. 1989 Aug;210(2):127–138. doi: 10.1097/00000658-198908000-00001. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Yamamoto J., Sugihara K., Kosuge T., Takayama T., Shimada K., Yamasaki S., Sakamoto M., Hirohashi S. Pathologic support for limited hepatectomy in the treatment of liver metastases from colorectal cancer. Ann Surg. 1995 Jan;221(1):74–78. doi: 10.1097/00000658-199501000-00009. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Annals of Surgery are provided here courtesy of Lippincott, Williams, and Wilkins

RESOURCES