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. 1988 Jan;395:1–16. doi: 10.1113/jphysiol.1988.sp016905

Vagally mediated gastric motor and emetic reflexes evoked by stimulation of the antral mucosa in anaesthetized ferrets.

P L Andrews 1, K L Wood 1
PMCID: PMC1191980  PMID: 3411476

Abstract

1. In the urethane-anaesthetized ferret chemical (NaCl, NaOH or HCl) or mechanical (stroking) stimulation of the gastric antral mucosa evoked a decrease in corpus pressure and inhibition of contractions in the presence of guanethidine, adrenalectomy and sectioned greater splanchnic nerves. 2. The fall in corpus pressure was present following administration of atropine but was abolished by vagotomy. 3. Preliminary evidence, using 100 mM-NaOH as the stimulus, is presented that the effects on corpus motility are due to simultaneous activation of the vagal efferents supplying the intramural non-adrenergic non-cholinergic inhibitory neurones and inhibition of those supplying the intramural cholinergic neurones. 4. The possible roles of this antro-corpus vago-vagal reflex in the regulation of gastric emptying and in the prodromal phase of vomiting are discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Abrahamsson H. Vagal relaxation of the stomach induced from the gastric antrum. Acta Physiol Scand. 1973 Nov;89(3):406–414. doi: 10.1111/j.1748-1716.1973.tb05535.x. [DOI] [PubMed] [Google Scholar]
  2. Akwari O. E. The gastrointestinal tract in chemotherapy-induced emesis. A final common pathway. Drugs. 1983 Feb;25 (Suppl 1):18–34. doi: 10.2165/00003495-198300251-00004. [DOI] [PubMed] [Google Scholar]
  3. Andrews P. L., Fussey I. V., Scratcherd T. The spontaneous discharge in abdominal vagal efferents in the dog and ferret. Pflugers Arch. 1980 Aug;387(1):55–60. doi: 10.1007/BF00580844. [DOI] [PubMed] [Google Scholar]
  4. Andrews P. L., Lawes I. N. Characteristics of the vagally driven non-adrenergic, non-cholinergic inhibitory innervation of ferret gastric corpus. J Physiol. 1985 Jun;363:1–20. doi: 10.1113/jphysiol.1985.sp015692. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Andrews P. L. The non-adrenergic non-cholinergic innervation of the stomach. Arch Int Pharmacodyn Ther. 1986 Apr;280(2 Suppl):84–109. [PubMed] [Google Scholar]
  6. Andrews P. L. Vagal afferent innervation of the gastrointestinal tract. Prog Brain Res. 1986;67:65–86. doi: 10.1016/s0079-6123(08)62757-0. [DOI] [PubMed] [Google Scholar]
  7. Barker G. R., Cochrane G. M., Corbett G. A., Hunt J. N., Roberts S. K. Actions of glucose and potassium chloride on osmoreceptors slowing gastric emptying. J Physiol. 1974 Feb;237(1):183–186. doi: 10.1113/jphysiol.1974.sp010476. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Becker J. M., Kelly K. A. Antral control of canine gastric emptying of solids. Am J Physiol. 1983 Sep;245(3):G334–G338. doi: 10.1152/ajpgi.1983.245.3.G334. [DOI] [PubMed] [Google Scholar]
  9. Clarke G. D., Davison J. S. Mucosal receptors in the gastric antrum and small intestine of the rat with afferent fibres in the cervical vagus. J Physiol. 1978 Nov;284:55–67. doi: 10.1113/jphysiol.1978.sp012527. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Cottrell D. F., Iggo A. Mucosal enteroceptors with vagal afferent fibres in the proximal duodenum of sheep. J Physiol. 1984 Sep;354:497–522. doi: 10.1113/jphysiol.1984.sp015390. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Cottrell D. F., Iggo A. Tension receptors with vagal afferent fibres in the proximal duodenum and pyloric sphincter of sheep. J Physiol. 1984 Sep;354:457–475. doi: 10.1113/jphysiol.1984.sp015388. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Davison J. S., Grundy D. Modulation of single vagal efferent fibre discharge by gastrointestinal afferents in the rat. J Physiol. 1978 Nov;284:69–82. doi: 10.1113/jphysiol.1978.sp012528. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Davison J. S. Response of single vagal afferent fibres to mechanical and chemical stimulation of the gastric and duodenal mucosa in cats. Q J Exp Physiol Cogn Med Sci. 1972 Oct;57(4):405–416. doi: 10.1113/expphysiol.1972.sp002176. [DOI] [PubMed] [Google Scholar]
  14. Gleysteen J. J., Sarna S. K., Myrvik A. L. Canine cyclic motor activity of stomach and small bowel: the vagus is not the governor. Gastroenterology. 1985 Jun;88(6):1926–1931. doi: 10.1016/0016-5085(85)90021-6. [DOI] [PubMed] [Google Scholar]
  15. Grundy D., Salih A. A., Scratcherd T. Modulation of vagal efferent fibre discharge by mechanoreceptors in the stomach, duodenum and colon of the ferret. J Physiol. 1981;319:43–52. doi: 10.1113/jphysiol.1981.sp013890. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. HUNT J. N. Some properties of an alimentary osmoreceptor mechanism. J Physiol. 1956 May 28;132(2):267–288. doi: 10.1113/jphysiol.1956.sp005524. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Kuwahara A. Changes in the gastric motility by the chemical and mechanical stimulations in the dog. Jpn J Physiol. 1983;33(1):29–40. doi: 10.2170/jjphysiol.33.29. [DOI] [PubMed] [Google Scholar]
  18. Kuwahara A. Role of vagal and splanchnic nerves for gastric motility changes in response to chemical stimulation of canine gastric mucosa. Jpn J Physiol. 1983;33(2):239–247. doi: 10.2170/jjphysiol.33.239. [DOI] [PubMed] [Google Scholar]
  19. Leek B. F. Abdominal and pelvic visceral receptors. Br Med Bull. 1977 May;33(2):163–168. doi: 10.1093/oxfordjournals.bmb.a071417. [DOI] [PubMed] [Google Scholar]
  20. Mackay T. W., Andrews P. L. A comparative study of the vagal innervation of the stomach in man and the ferret. J Anat. 1983 May;136(Pt 3):449–481. [PMC free article] [PubMed] [Google Scholar]
  21. McCarthy L. E., Borison H. L. Respiratory mechanics of vomiting in decerebrate cats. Am J Physiol. 1974 Mar;226(3):738–743. doi: 10.1152/ajplegacy.1974.226.3.738. [DOI] [PubMed] [Google Scholar]
  22. Minami H., McCallum R. W. The physiology and pathophysiology of gastric emptying in humans. Gastroenterology. 1984 Jun;86(6):1592–1610. [PubMed] [Google Scholar]
  23. PAINTAL A. S. Responses from mucosal mechanoreceptors in the small intestine of the cat. J Physiol. 1957 Dec 31;139(3):353–368. doi: 10.1113/jphysiol.1957.sp005896. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Paintal A. S. Vagal sensory receptors and their reflex effects. Physiol Rev. 1973 Jan;53(1):159–227. doi: 10.1152/physrev.1973.53.1.159. [DOI] [PubMed] [Google Scholar]

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