Abstract
1. Intraventricular injection of rabbit and human serum albumin, and rabbit endogenous pyrogen produced dose-dependent fevers in rabbits. The pyrogenicity of albumin was less than one-twentieth of the pyrogenicity of endogenous pyrogen. 2. Fevers induced by ventricular albumin were significantly suppressed by intraventricular injection of indomethacin which is a cyclooxygenase inhibitor. In contrast, subcutaneous injection had no effect. 3. Ventricular endogenous pyrogen induced several of the acute phase responses, i.e. decreases in the plasma concentration of iron and zinc, and increases in both the plasma concentration of copper and the white blood cell count. Albumin induced none of these responses. 4. It is concluded that fever induced by ventricular albumin is processed by prostaglandins synthesized within the central nervous system. However, ventricular albumin does not activate the central mechanism to induce acute phase responses.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- ATKINS E. Pathogenesis of fever. Physiol Rev. 1960 Jul;40:580–646. doi: 10.1152/physrev.1960.40.3.580. [DOI] [PubMed] [Google Scholar]
- Blatteis C. M., Hunter W. S., Llanos J., Ahokas R. A., Mashburn T. A., Jr Activation of acute-phase responses by intrapreoptic injections of endogenous pyrogen in guinea pigs. Brain Res Bull. 1984 Jun;12(6):689–695. doi: 10.1016/0361-9230(84)90149-7. [DOI] [PubMed] [Google Scholar]
- Hattingh J., Laburn H., Mitchell D. Fever induced in rabbits by intravenous injection of bovine serum albumin. J Physiol. 1979 May;290(2):69–77. doi: 10.1113/jphysiol.1979.sp012760. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Merriman C. R., Upchurch H. F., Kampschmidt R. F. Prostaglandin E1, aspirin and the action of leukocytic endogenous mediator. J Pharmacol Exp Ther. 1974 Mar;188(3):516–519. [PubMed] [Google Scholar]
- Milton A. S., Wendlandt S. Effects on body temperature of prostaglandins of the A, E and F series on injection into the third ventricle of unanaesthetized cats and rabbits. J Physiol. 1971 Oct;218(2):325–336. doi: 10.1113/jphysiol.1971.sp009620. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Morimoto A., Murakami N., Nakamori T., Watanabe T. Evidence for separate mechanisms of induction of biphasic fever inside and outside the blood-brain barrier in rabbits. J Physiol. 1987 Feb;383:629–637. doi: 10.1113/jphysiol.1987.sp016433. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Morimoto A., Watanabe T., Ono T., Sakata Y., Murakami N. Rat endogenous pyrogen and fever. Am J Physiol. 1986 May;250(5 Pt 2):R776–R782. doi: 10.1152/ajpregu.1986.250.5.R776. [DOI] [PubMed] [Google Scholar]
- Rudy T. A., Westergaard J. L., Yaksh T. L. Hyperthermia produced by simulated intraventricular hemorrhage in the cat. Exp Neurol. 1978 Jan 15;58(2):296–310. doi: 10.1016/0014-4886(78)90142-5. [DOI] [PubMed] [Google Scholar]