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. 1987 Mar;384:169–197. doi: 10.1113/jphysiol.1987.sp016449

Sodium current kinetics in cat atrial myocytes.

C H Follmer 1, R E ten Eick 1, J Z Yeh 1
PMCID: PMC1192257  PMID: 2443658

Abstract

1. Na+ current kinetics were studied in isolated atrial myocytes from the adult cat using the single suction-pipette voltage-clamp technique. 2. Current-voltage and conductance-voltage relationships were similar to those described in other cardiac myocyte preparations. 3. Analysis of Na+ current decay using single-pulse, double-pulse and tail current measurements were in agreement and demonstrate a second-order process of current decay. 4. Voltage dependence of steady-state inactivation curves was not symmetrical, having an inflexion at about -90 mV. These results suggest more than a single inactivation process for Na+ channel in the negative potential region. 5. Recovery of Na+ current from inactivation had a sigmoid time course: an initial slow component (delay) followed by a fast and then a second slow component. Increasing the pre-pulse duration slowed the time course of recovery. 6. Taken together, the results were consistent with the presence of multiple inactivated states for the atrial myocyte Na+ channel.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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