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. 1984 Sep;354:547–556. doi: 10.1113/jphysiol.1984.sp015392

Excitation of the cardiac vagus by vasopressin in mammals.

G P Courtice, T E Kwong, E R Lumbers, E K Potter
PMCID: PMC1193428  PMID: 6481644

Abstract

In unanaesthetized sheep, the sensitivity of the baroreceptor-cardio-inhibitory reflex was greater when intravenous vasopressin was used to raise blood pressure, than when intravenous phenylephrine was used to raise blood pressure. This difference was still evident in animals in which beta-adrenergic blockade had been carried out using propranolol. In the presence of combined beta-adrenergic and muscarinic blockade, a direct negative chronotropic effect of intravenous vasopressin could not be demonstrated. It was concluded, therefore, that intravenous vasopressin enhanced cardiac vagal tone. This effect of vasopressin on efferent cardiac vagal tone was confirmed directly in anaesthetized dogs by recording from single cardiac vagal efferent fibres. Furthermore, recordings from single carotid sinus baroreceptor fibres did not demonstrate a direct action of vasopressin on the sensitivity of the baroreceptors. However, the pressor effect of vasopressin is associated with a greater increase in efferent cardiac vagal discharge than that seen when equipressor doses of phenylephrine are given, or when blood pressure is raised by a similar amount by inflation of an intra-aortic balloon. Studies in isolated guinea-pig atrial preparations and in anaesthetized rabbits and dogs, revealed no consistent peripheral action of vasopressin on the action of the vagus at the heart.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bonjour J. P., Malvin R. L. Plasma concentrations of ADH in conscious and anesthetized dogs. Am J Physiol. 1970 Apr;218(4):1128–1132. doi: 10.1152/ajplegacy.1970.218.4.1128. [DOI] [PubMed] [Google Scholar]
  2. Coleridge H. M., Coleridge J. C. Cardiovascular afferents involved in regulation of peripheral vessels. Annu Rev Physiol. 1980;42:413–427. doi: 10.1146/annurev.ph.42.030180.002213. [DOI] [PubMed] [Google Scholar]
  3. Courtice G. P., Potter E. K., McCloskey D. I. Potentiation of the action of the vagus nerve on the heart in severe hypoxia. J Auton Nerv Syst. 1983 Feb;7(2):175–178. doi: 10.1016/0165-1838(83)90045-0. [DOI] [PubMed] [Google Scholar]
  4. Davis A. L., McCloskey D. I., Potter E. K. Respiratory modulation of baroreceptor and chemoreceptor reflexes affecting heart rate through the sympathetic nervous system. J Physiol. 1977 Nov;272(3):691–703. doi: 10.1113/jphysiol.1977.sp012067. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Heyndrickx G. R., Boettcher D. H., Vatner S. F. Effects of angiotensin, vasopressin, and methoxamine on cardiac function and blood flow distribution in conscious dogs. Am J Physiol. 1976 Nov;231(5 Pt 1):1579–1587. doi: 10.1152/ajplegacy.1976.231.5.1579. [DOI] [PubMed] [Google Scholar]
  6. Imai Y., Nolan P. L., Johnston C. I. Endogenous vasopressin modulates the baroreflex sensitivity in rats. Clin Exp Pharmacol Physiol. 1983 May-Jun;10(3):289–292. doi: 10.1111/j.1440-1681.1983.tb00199.x. [DOI] [PubMed] [Google Scholar]
  7. Ismay M. J., Lumbers E. R., Stevens A. D. The action of angiotensin II on the baroreflex response of the conscious ewe and the conscious fetus. J Physiol. 1979 Mar;288:467–479. [PMC free article] [PubMed] [Google Scholar]
  8. Liard J. F., Dériaz O., Tschopp M., Schoun J. Cardiovascular effects of vasopressin infused into the vertebral circulation of conscious dogs. Clin Sci (Lond) 1981 Sep;61(3):345–347. doi: 10.1042/cs0610345. [DOI] [PubMed] [Google Scholar]
  9. Lumbers E. R., McCloskey D. I., Potter E. K. Inhibition by angiotensin II of baroreceptor-evoked activity in cardiac vagal efferent nerves in the dog. J Physiol. 1979 Sep;294:69–80. doi: 10.1113/jphysiol.1979.sp012915. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Lumbers E. R., Potter E. K. Inhibition of the vagal component of the baroreceptor-cardioinhibitory reflex by angiotensin III in dogs and sheep. J Physiol. 1983 Mar;336:83–89. doi: 10.1113/jphysiol.1983.sp014568. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Lumbers E. R., Potter E. K. The effects of vasoactive peptides on the carotid cardiac baroreflex. Clin Exp Pharmacol Physiol Suppl. 1982;7:45–49. [PubMed] [Google Scholar]
  12. Montani J. P., Liard J. F., Schoun J., Möhring J. Hemodynamic effects of exogenous and endogenous vasopressin at low plasma concentrations in conscious dogs. Circ Res. 1980 Sep;47(3):346–355. doi: 10.1161/01.res.47.3.346. [DOI] [PubMed] [Google Scholar]
  13. Nakashima A., Angus J. A., Johnston C. I. Chronotropic effects of angiotensin I, angiotensin II, bradykinin and vasopressin in guinea pig atria. Eur J Pharmacol. 1982 Jul 16;81(3):479–485. doi: 10.1016/0014-2999(82)90113-3. [DOI] [PubMed] [Google Scholar]
  14. Potter E. K. Angiotensin inhibits action of vagus nerve at the heart. Br J Pharmacol. 1982 Jan;75(1):9–11. doi: 10.1111/j.1476-5381.1982.tb08752.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Schwartz J., Keil L. C., Maselli J., Reid I. A. Role of vasopressin in blood pressure regulation during adrenal insufficiency. Endocrinology. 1983 Jan;112(1):234–238. doi: 10.1210/endo-112-1-234. [DOI] [PubMed] [Google Scholar]
  16. Schwartz J., Reid I. A. Effect of vasopressin blockade on blood pressure regulation during hemorrhage in conscious dogs. Endocrinology. 1981 Nov;109(5):1778–1780. doi: 10.1210/endo-109-5-1778. [DOI] [PubMed] [Google Scholar]
  17. Smyth H. S., Sleight P., Pickering G. W. Reflex regulation of arterial pressure during sleep in man. A quantitative method of assessing baroreflex sensitivity. Circ Res. 1969 Jan;24(1):109–121. doi: 10.1161/01.res.24.1.109. [DOI] [PubMed] [Google Scholar]
  18. VARMA S., JOHNSEN S. D., SHERMAN D. E., YOUMANS W. B. Mechanisms of inhibition of heart rate by phenylephrine. Circ Res. 1960 Nov;8:1182–1186. doi: 10.1161/01.res.8.6.1182. [DOI] [PubMed] [Google Scholar]
  19. Varma S., Jaju B. P., Bhargava K. P. Mechanism of vasopressin-induced bradycardia in dogs. Circ Res. 1969 Jun;24(6):787–792. doi: 10.1161/01.res.24.6.787. [DOI] [PubMed] [Google Scholar]

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