Skip to main content
PMC home page
Genitourinary Medicine logoLink to Genitourinary Medicine
. 1987 Feb;63(1):28–31. doi: 10.1136/sti.63.1.28

Infection with human immunodeficiency virus (HIV) and cytomegalovirus in a London health district 1980-4.

M G Ross, D M Burns, J E Grundy, P D Griffiths
PMCID: PMC1194003  PMID: 3028935

Abstract

By testing serum samples taken between 1980 and 1984 from men attending a department of sexually transmitted diseases, it was shown that antibodies to human immunodeficiency virus (HIV) first appeared in 1981. Homosexual men were significantly more likely to have antibodies to HIV and to cytomegalovirus (CMV) than were heterosexual men attending the same clinic. This shows that homosexuals are exposed to both HIV, the cause of the acquired immune deficiency syndrome (AIDS), and to CMV, which can reactivate to cause life threatening disease once immunosuppression has developed. All homosexuals, not just those with antibodies against HIV, had raised levels of CMV antibodies. This suggests that they experience frequent antigenic stimulation after reinfections with CMV or reactivation of endogenous virus.

Full text

PDF
29

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Barré-Sinoussi F., Chermann J. C., Rey F., Nugeyre M. T., Chamaret S., Gruest J., Dauguet C., Axler-Blin C., Vézinet-Brun F., Rouzioux C. Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS). Science. 1983 May 20;220(4599):868–871. doi: 10.1126/science.6189183. [DOI] [PubMed] [Google Scholar]
  2. Carne C. A., Weller I. V., Sutherland S., Cheingsong-Popov R., Ferns R. B., Williams P., Mindel A., Tedder R., Adler M. W. Rising prevalence of human T-lymphotropic virus type III (HTLV-III) infection in homosexual men in London. Lancet. 1985 Jun 1;1(8440):1261–1262. doi: 10.1016/s0140-6736(85)92324-4. [DOI] [PubMed] [Google Scholar]
  3. Cheingsong-Popov R., Weiss R. A., Dalgleish A., Tedder R. S., Shanson D. C., Jeffries D. J., Ferns R. B., Briggs E. M., Weller I. V., Mitton S. Prevalence of antibody to human T-lymphotropic virus type III in AIDS and AIDS-risk patients in Britain. Lancet. 1984 Sep 1;2(8401):477–480. doi: 10.1016/s0140-6736(84)92562-5. [DOI] [PubMed] [Google Scholar]
  4. Drew W. L., Mintz L., Miner R. C., Sands M., Ketterer B. Prevalence of cytomegalovirus infection in homosexual men. J Infect Dis. 1981 Feb;143(2):188–192. doi: 10.1093/infdis/143.2.188. [DOI] [PubMed] [Google Scholar]
  5. Gallo R. C., Salahuddin S. Z., Popovic M., Shearer G. M., Kaplan M., Haynes B. F., Palker T. J., Redfield R., Oleske J., Safai B. Frequent detection and isolation of cytopathic retroviruses (HTLV-III) from patients with AIDS and at risk for AIDS. Science. 1984 May 4;224(4648):500–503. doi: 10.1126/science.6200936. [DOI] [PubMed] [Google Scholar]
  6. Griffiths P. D., Kangro H. O. A user's guide to the indirect solid-phase radioimmunoassay for the detection of cytomegalovirus-specific IgM antibodies. J Virol Methods. 1984 Jul;8(4):271–282. doi: 10.1016/0166-0934(84)90064-8. [DOI] [PubMed] [Google Scholar]
  7. Groopman J. E., Salahuddin S. Z., Sarngadharan M. G., Mullins J. I., Sullivan J. L., Mulder C., O'Hara C. J., Cheeseman S. H., Haverkos H., Forgacs P. Virologic studies in a case of transfusion-associated AIDS. N Engl J Med. 1984 Nov 29;311(22):1419–1422. doi: 10.1056/NEJM198411293112206. [DOI] [PubMed] [Google Scholar]
  8. Jaffe H. W., Darrow W. W., Echenberg D. F., O'Malley P. M., Getchell J. P., Kalyanaraman V. S., Byers R. H., Drennan D. P., Braff E. H., Curran J. W. The acquired immunodeficiency syndrome in a cohort of homosexual men. A six-year follow-up study. Ann Intern Med. 1985 Aug;103(2):210–214. doi: 10.7326/0003-4819-103-2-210. [DOI] [PubMed] [Google Scholar]
  9. Levy J. A., Hoffman A. D., Kramer S. M., Landis J. A., Shimabukuro J. M., Oshiro L. S. Isolation of lymphocytopathic retroviruses from San Francisco patients with AIDS. Science. 1984 Aug 24;225(4664):840–842. doi: 10.1126/science.6206563. [DOI] [PubMed] [Google Scholar]
  10. Miller R. A., Collier A. C., Buchanan T. M., Handsfield H. H. Seroepidemiologic screening for antibodies to LAV/HTLV-III in Sri Lanka, 1980-1982. N Engl J Med. 1985 Nov 21;313(21):1352–1353. doi: 10.1056/NEJM198511213132113. [DOI] [PubMed] [Google Scholar]
  11. Pinching A. J., McManus T. J., Jeffries D. J., Moshtael O., Donaghy M., Parkin J. M., Munday P. E., Harris J. R. Studies of cellular immunity in male homosexuals in London. Lancet. 1983 Jul 16;2(8342):126–130. doi: 10.1016/s0140-6736(83)90115-0. [DOI] [PubMed] [Google Scholar]
  12. Popovic M., Sarngadharan M. G., Read E., Gallo R. C. Detection, isolation, and continuous production of cytopathic retroviruses (HTLV-III) from patients with AIDS and pre-AIDS. Science. 1984 May 4;224(4648):497–500. doi: 10.1126/science.6200935. [DOI] [PubMed] [Google Scholar]
  13. Sarngadharan M. G., Popovic M., Bruch L., Schüpbach J., Gallo R. C. Antibodies reactive with human T-lymphotropic retroviruses (HTLV-III) in the serum of patients with AIDS. Science. 1984 May 4;224(4648):506–508. doi: 10.1126/science.6324345. [DOI] [PubMed] [Google Scholar]
  14. Schüpbach J., Popovic M., Gilden R. V., Gonda M. A., Sarngadharan M. G., Gallo R. C. Serological analysis of a subgroup of human T-lymphotropic retroviruses (HTLV-III) associated with AIDS. Science. 1984 May 4;224(4648):503–505. doi: 10.1126/science.6200937. [DOI] [PubMed] [Google Scholar]
  15. Weiss R. Retroviruses linked with AIDS. Nature. 1984 May 3;309(5963):12–13. doi: 10.1038/309012a0. [DOI] [PubMed] [Google Scholar]
  16. du Bois R. M., Branthwaite M. A., Mikhail J. R., Batten J. C. Primary Pneumocystis carinii and cytomegalovirus infections. Lancet. 1981 Dec 12;2(8259):1339–1339. doi: 10.1016/s0140-6736(81)91353-2. [DOI] [PubMed] [Google Scholar]

Articles from Genitourinary Medicine are provided here courtesy of BMJ Publishing Group

RESOURCES