Skip to main content
NCBI home page
Genitourinary Medicine logoLink to Genitourinary Medicine
. 1988 Feb;64(1):18–21. doi: 10.1136/sti.64.1.18

Influence of gender in pathogenesis of trichomoniasis in congenitally athymic (nude) mice.

M G Martinotti 1, T Musso 1, D Savoia 1
PMCID: PMC1194140  PMID: 3346023

Abstract

Evaluation of abscesses appearing in male and female euthymic and athymic (nude) Balb/c mice after subcutaneous injection of Trichomonas vaginalis in the dorsal region showed that females were more susceptible than males. Female euthymic mice, however, were more susceptible than male athymic mice, and splenectomised athymic males were more susceptible than non-splenectomised athymic males. F1 female athymic mice were the most susceptible, as their abscesses reached a peak size five days earlier than those of athymic homozygous females. F1 male athymic mice, though slightly more susceptible than athymic homozygous males, did not develop abscesses that were similar in size. These results suggest that resistance or susceptibility to T vaginalis infection depends on the gender of the host and on thymus dependent cellular populations.

Full text

PDF
18

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Denham D. A. Studies with Brugia pahangi. 6. The susceptibility of male and female cats to infection. J Parasitol. 1974 Aug;60(4):642–642. [PubMed] [Google Scholar]
  2. Frayha G. J., Lawlor W. K., Dajani R. M. Echinococcus granulosus in albino mice: effect of host sex and sex hormones on the growth of hydatid cysts. Exp Parasitol. 1971 Apr;29(2):255–262. doi: 10.1016/0014-4894(71)90032-4. [DOI] [PubMed] [Google Scholar]
  3. Giannini M. S. Sex-influenced response in the pathogenesis of cutaneous leishmaniasis in mice. Parasite Immunol. 1986 Jan;8(1):31–37. doi: 10.1111/j.1365-3024.1986.tb00831.x. [DOI] [PubMed] [Google Scholar]
  4. Golstein P., Wigzell H., Blomgren H., Svedmyr E. A. Cells mediating specific in vitro cytotoxicity. II. Probable autonomy of thymus-processed lymphocytes (T cells) for the killing of allogeneic target cells. J Exp Med. 1972 Apr 1;135(4):890–906. doi: 10.1084/jem.135.4.890. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Greenblatt H. C., Rosenstreich D. L. Trypanosoma rhodesiense infection in mice: sex dependence of resistance. Infect Immun. 1984 Jan;43(1):337–340. doi: 10.1128/iai.43.1.337-340.1984. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. HONIGBERG B. M. Comparative pathogenicity of Trichomonas vaginalis and Trichomonas gallinae to mice. I. Gross pathology, quantitative evaluation of virulence, and some factors affecting pathogenicity. J Parasitol. 1961 Aug;47:545–571. [PubMed] [Google Scholar]
  7. Heine J., Moon H. W., Woodmansee D. B. Persistent Cryptosporidium infection in congenitally athymic (nude) mice. Infect Immun. 1984 Mar;43(3):856–859. doi: 10.1128/iai.43.3.856-859.1984. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Herberman R. B., Holden H. T. Natural cell-mediated immunity. Adv Cancer Res. 1978;27:305–377. doi: 10.1016/s0065-230x(08)60936-7. [DOI] [PubMed] [Google Scholar]
  9. Ito A. Thymus dependency of induced immune responses against Hymenolepis nana (cestode) using congenitally athymic nude mice. Clin Exp Immunol. 1985 Apr;60(1):87–94. [PMC free article] [PubMed] [Google Scholar]
  10. Landolfo S., Martinotti M. G., Martinetto P., Forni G., Rabagliati A. M. Trichomonas vaginalis: dependence of resistance among different mouse strains upon the non-H-2 gene haplotype, sex, and age of recipient hosts. Exp Parasitol. 1981 Dec;52(3):312–318. doi: 10.1016/0014-4894(81)90089-8. [DOI] [PubMed] [Google Scholar]
  11. Mitchell G. F. Metazoan and protozoan parasitic infections in nude mice. Contemp Top Immunobiol. 1978;8:55–67. doi: 10.1007/978-1-4684-0922-2_3. [DOI] [PubMed] [Google Scholar]
  12. Pantelouris E. M. Observations on the immunobiology of 'nude' mice. Immunology. 1971 Feb;20(2):247–252. [PMC free article] [PubMed] [Google Scholar]
  13. Pritchard H., Micklem H. S. Immune responses in congenitally thymus-less mice. I. Absence of response to oxazolone. Clin Exp Immunol. 1972 Jan;10(1):151–161. [PMC free article] [PubMed] [Google Scholar]
  14. Reddington J. J., Stewart G. L., Kramar G. W., Kramar M. A. The effects of host sex and hormones on Trichinella spiralis in the mouse. J Parasitol. 1981 Aug;67(4):548–555. [PubMed] [Google Scholar]
  15. Rein M. F., Chapel T. A. Trichomoniasis, candidiasis, and the minor venereal diseases. Clin Obstet Gynecol. 1975 Mar;18(1):73–88. doi: 10.1097/00003081-197503000-00008. [DOI] [PubMed] [Google Scholar]
  16. Roberts-Thomson I. C., Mitchell G. F. Giardiasis in mice. I. Prolonged infections in certain mouse strains and hypothymic (nude) mice. Gastroenterology. 1978 Jul;75(1):42–46. [PubMed] [Google Scholar]
  17. Santoli D., Trinchieri G., Zmijewski C. M., Koprowski H. HLA-related control of spontaneous and antibody-dependent cell-mediated cytotoxic activity in humans. J Immunol. 1976 Sep;117(3):765–770. [PubMed] [Google Scholar]
  18. Spence M. R., Hollander D. H., Smith J., McCaig L., Sewell D., Brockman M. The clinical and laboratory diagnosis of Trichomonas vaginalis infection. Sex Transm Dis. 1980 Oct-Dec;7(4):168–171. doi: 10.1097/00007435-198010000-00004. [DOI] [PubMed] [Google Scholar]
  19. Wagner H., Harris A. W., Feldmann M. Cell-mediated immune response in vitro. II. The role of thymus and thymus-derived lymphocytes. Cell Immunol. 1972 May;4(1):39–50. doi: 10.1016/0008-8749(72)90004-4. [DOI] [PubMed] [Google Scholar]
  20. Wortis H. H. Immunological responses of 'nude' mice. Clin Exp Immunol. 1971 Feb;8(2):305–317. [PMC free article] [PubMed] [Google Scholar]

Articles from Genitourinary Medicine are provided here courtesy of BMJ Publishing Group

RESOURCES