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. 1983 Feb;335:481–493. doi: 10.1113/jphysiol.1983.sp014545

Reinnervation of striated muscle by peripheral vagal fibres cut above or below the nodose ganglion in the cat and rabbit.

J Coget, J P Rousseau
PMCID: PMC1197364  PMID: 6875889

Abstract

In cats and rabbits, the peripheral stump of the vagus nerve cut above the nodose ganglion (supranodose anastomoses: s.n.) or below this ganglion (infranodose anastomoses: i.n.) was either sutured with epineurial sutures to the peripheral stump of the branch of the spinal accessory motor nerve innervating the sterno-cleido-mastoid (s.c.m.) muscle, or directly implanted in this muscle after resection of its motor nerve. After about six months, reinnervation of this muscle by vagal fibres was studied. By electromyographic recording during electrical stimulation of the cervical vagus nerve, it was shown that the vagal reinnervation of the s.c.m. muscle was established in 65% of the cats studied (57% s.n., 69% i.n.) and 33% of rabbits (37% s.n. and 31% i.n.). The average number of distinct potentials recorded in the reinnervated muscle, following vagal stimulation, was twenty-two in s.n. cats, thirteen in i.n. cats, eleven in s.n. rabbits and twelve in i.n. rabbits. Recorded potentials were monophasic (8%), biphasic (22.5%), triphasic (11.5%) or polyphasic (58%). These potentials were abolished by curare and alpha-bungarotoxin. The use of retrograde axonal transport of horseradish peroxidase showed labelled cells in the nodose ganglion, the cervical vagus and cranial thoracic vagus, and in the stellate ganglia. It is concluded that cholinergic vagal afferents reinnervated the s.c.m. muscle. Involvement of the sympathetic system is discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. AGOSTONI E., CHINNOCK J. E., DE DALY M. B., MURRAY J. G. Functional and histological studies of the vagus nerve and its branches to the heart, lungs and abdominal viscera in the cat. J Physiol. 1957 Jan 23;135(1):182–205. doi: 10.1113/jphysiol.1957.sp005703. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Adrian E. D., Bronk D. W. The discharge of impulses in motor nerve fibres: Part II. The frequency of discharge in reflex and voluntary contractions. J Physiol. 1929 Mar 20;67(2):i3–151. [PMC free article] [PubMed] [Google Scholar]
  3. BUCHTHAL F., GULD C., ROSENFALCK P. Volume conduction of the spike of the motor unit potential investigated with a new type of multielectrode. Acta Physiol Scand. 1957 Mar 7;38(3-4):331–354. doi: 10.1111/j.1748-1716.1957.tb01396.x. [DOI] [PubMed] [Google Scholar]
  4. Bennett M. R., McLachlan E. M., Taylor R. S. The formation of synapses in mammalian striated muscle reinnervated with autonomic preganglionic nerves. J Physiol. 1973 Sep;233(3):501–517. doi: 10.1113/jphysiol.1973.sp010320. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Bennett M. R., McLachlan E. M., Taylor R. S. The formation of synapses in reinnervated mammalian striated muscle. J Physiol. 1973 Sep;233(3):481–500. doi: 10.1113/jphysiol.1973.sp010319. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Bon C., Changeux J. P. Chemical and pharmacological characterization of toxic polypeptides from the venom of Bungarus caeruleus. Eur J Biochem. 1977 Mar 15;74(1):31–42. doi: 10.1111/j.1432-1033.1977.tb11363.x. [DOI] [PubMed] [Google Scholar]
  7. Brimijoin S., Lundberg J. M., Brodin E., Hökfelt T., Nilsson G. Axonal transport of substance P in the vagus and sciatic nerves of the guinea pig. Brain Res. 1980 Jun 9;191(2):443–457. doi: 10.1016/0006-8993(80)91293-7. [DOI] [PubMed] [Google Scholar]
  8. DE CASTRO F. Aspects anatomiques de la transmission synaptique ganglionnaire chez les mammifères. Arch Int Physiol. 1951 Dec;59(4):479–525. doi: 10.3109/13813455109150845. [DOI] [PubMed] [Google Scholar]
  9. DUSSARDIER M. [Fluctuating form of the potentials of motor units of a reinnervated diaphragm]. C R Seances Soc Biol Fil. 1960;154:34–38. [PubMed] [Google Scholar]
  10. EDDS M. V., Jr Collateral nerve regeneration. Q Rev Biol. 1953 Sep;28(3):260–276. doi: 10.1086/399699. [DOI] [PubMed] [Google Scholar]
  11. EVANS D. H., MURRAY J. G. Histological and functional studies on the fibre composition of the vagus nerve of the rabbit. J Anat. 1954 Jul;88(3):320–337. [PMC free article] [PubMed] [Google Scholar]
  12. Falempin M., Rousseau J. P. Reinnervation of skeletal muscles by vagal sensory fibres in the sheep, cat and rabbit. J Physiol. 1983 Feb;335:467–479. doi: 10.1113/jphysiol.1983.sp014544. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Forman D. S., Wood D. K., DeSilva S. Rate of regeneration of sensory axons in transected rat sciatic nerve repaired with epineurial sutures. J Neurol Sci. 1979 Dec;44(1):55–59. doi: 10.1016/0022-510x(79)90222-3. [DOI] [PubMed] [Google Scholar]
  14. Fujiwara M., Kurahashi K. Cholinergic nature of the primary afferent vagus synapsed in cross anastomosed superior cervical ganglia. Life Sci. 1976 Oct 15;19(8):1175–1180. doi: 10.1016/0024-3205(76)90252-6. [DOI] [PubMed] [Google Scholar]
  15. Fujiwara M., Kurahashi K., Mizuno N., Nakamura Y. Involvement of nicotinic and muscarinic receptors in synaptic transmission in cat superior cervical ganglions reinnervated by vagal primary afferent axons. J Pharmacol Exp Ther. 1978 Apr;205(1):77–90. [PubMed] [Google Scholar]
  16. Gamse R., Lembeck F., Cuello A. C. Substance P in the vagus nerve. Immunochemical and immunohistochemical evidence for axoplasmic transport. Naunyn Schmiedebergs Arch Pharmacol. 1979 Jan;306(1):37–44. doi: 10.1007/BF00515591. [DOI] [PubMed] [Google Scholar]
  17. Gillis R. A., Helke C. J., Hamilton B. L., Norman W. P., Jacobowitz D. M. Evidence that substance P is a neurotransmitter of baro- and chemoreceptor afferents in nucleus tractus solitarius. Brain Res. 1980 Jan 13;181(2):476–481. doi: 10.1016/0006-8993(80)90633-2. [DOI] [PubMed] [Google Scholar]
  18. Grinnell A. D., Rheuben M. B. The physiology, pharmacology, and trophic effectiveness of synapses formed by autonomic preganglionic nerves on frog skeletal muscle. J Physiol. 1979 Apr;289:219–240. doi: 10.1113/jphysiol.1979.sp012734. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Gruber H. Motor innervation of striated oesophageal muscle. Part 2. Characteristics of the oesophagomotor fibres in the rat studied by implanting the vagus nerve into a skeletal muscle. J Neurol Sci. 1978 Apr;36(2):171–186. doi: 10.1016/0022-510x(78)90081-3. [DOI] [PubMed] [Google Scholar]
  20. Guth L. "Trophic" influences of nerve on muscle. Physiol Rev. 1968 Oct;48(4):645–687. doi: 10.1152/physrev.1968.48.4.645. [DOI] [PubMed] [Google Scholar]
  21. Gutmann E. The reinnervation of muscle by sensory nerve fibres. J Anat. 1945 Jan;79(Pt 1):1–8.4. [PMC free article] [PubMed] [Google Scholar]
  22. HOFFMAN H. H., KUNTZ A. Vagus nerve components. Anat Rec. 1957 Mar;127(3):551–567. doi: 10.1002/ar.1091270306. [DOI] [PubMed] [Google Scholar]
  23. Langley J. N., Anderson H. K. The union of different kinds of nerve fibres. J Physiol. 1904 Aug 22;31(5):365–391. doi: 10.1113/jphysiol.1904.sp001042. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. MATSUMURA M., KOELLE G. B. The nature of synaptic transmission in the superior cervical ganglion following reinnervation by the afferent vagus. J Pharmacol Exp Ther. 1961 Oct;134:28–46. [PubMed] [Google Scholar]
  25. MURRAY J. G., THOMPSON J. W. The occurrence and function of collateral sprouting in the sympathetic nervous system of the cat. J Physiol. 1957 Jan 23;135(1):133–162. doi: 10.1113/jphysiol.1957.sp005700. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. McArdle J. J., Albuquerque E. X. A study of the reinnervation of fast and slow mammalian muscles. J Gen Physiol. 1973 Jan;61(1):1–23. doi: 10.1085/jgp.61.1.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Mills E. Activity of aortic chemoreceptors during electrical stimulation of the stellate ganglion in the cat. J Physiol. 1968 Nov;199(1):103–114. doi: 10.1113/jphysiol.1968.sp008641. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. Muryobayashi T., Mori J., Fujiwara M., Shimamoto K. Fluorescence histochemical demonstration of adrenergic nerve fibers in the vagus nerve of cats and dogs. Jpn J Pharmacol. 1968 Sep;18(3):285–293. doi: 10.1254/jjp.18.285. [DOI] [PubMed] [Google Scholar]
  29. Niel J. P., Gonella J., Roman C. Localisation par la technique de marquage à la peroxydase des corps cellulaires des neurones ortho et parasympathiques innervant le sphincter oesophagien inférieur du chat. J Physiol (Paris) 1980 Nov;76(6):591–599. [PubMed] [Google Scholar]
  30. Nielsen K. C., Owman C., Santini M. Anastomosing adrenergic nerves from the sympathetic trunk to the vagus at the cervical level in the cat. Brain Res. 1969 Jan;12(1):1–9. doi: 10.1016/0006-8993(69)90050-x. [DOI] [PubMed] [Google Scholar]
  31. Rapoport S. Location of sternocleidomastoid and trapezius motoneurons in the cat. Brain Res. 1978 Nov 10;156(2):339–344. doi: 10.1016/0006-8993(78)90515-2. [DOI] [PubMed] [Google Scholar]
  32. Rousseau J. P., Falempin M. Activity of gut receptors in the conscious sheep. Ann Rech Vet. 1979;10(2-3):189–191. [PubMed] [Google Scholar]
  33. Spoendlin H., Lichtensteiger W. The sympathetic nerve supply to the inner ear. Arch Klin Exp Ohren Nasen Kehlkopfheilkd. 1967;189(4):346–359. doi: 10.1007/BF00440938. [DOI] [PubMed] [Google Scholar]
  34. Vera C. L., Luco J. V. Reinnervation of smooth and striated muscle by sensory nerve fibers. J Neurophysiol. 1967 May;30(3):620–627. doi: 10.1152/jn.1967.30.3.620. [DOI] [PubMed] [Google Scholar]

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