Abstract
In the rat ventral prostate gland the biosynthesis of putrescine, a precursor of spermidine and spermine, is shown to occur by the direct decarboxylation of l-ornithine. Some properties of a soluble pyridoxal phosphate-dependent l-ornithine decarboxylase are described. The findings are discussed in relation to other enzymic reactions involved in the biosynthesis of polyamines by the prostate gland.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Caldarera C. M., Barbiroli B., Moruzzi G. Polyamines and nucleic acids during development of the chick embryo. Biochem J. 1965 Oct;97(1):84–88. doi: 10.1042/bj0970084. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Dion A. S., Herbst E. J. The localization of spermidine in salivary gland cells of Drosophila melanogaster and its effect on H3-uridine incorporation. Proc Natl Acad Sci U S A. 1967 Dec;58(6):2367–2371. doi: 10.1073/pnas.58.6.2367. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Dykstra W. G., Jr, Herbst E. J. Spermidine in Regenerating Liver: Relation to Rapid Synthesis of Ribonucleic Acid. Science. 1965 Jul 23;149(3682):428–429. doi: 10.1126/science.149.3682.428. [DOI] [PubMed] [Google Scholar]
- Gale E. F. The production of amines by bacteria: The decarboxylation of amino-acids by strains of Bacterium coli. Biochem J. 1940 Mar;34(3):392–413. doi: 10.1042/bj0340392. [DOI] [PMC free article] [PubMed] [Google Scholar]
- HERBST E. J., KEISTER D. L., WEAVER R. H. The separation of aliphatic amines by paper chromatography or paper electrophoresis. Arch Biochem Biophys. 1958 May;75(1):178–185. doi: 10.1016/0003-9861(58)90408-9. [DOI] [PubMed] [Google Scholar]
- Hasse K., Ratych O. T., Salnikow J. Transaminierung und Decarboxylierung von Ornithin und Lysin in höheren Pflanzen. Hoppe Seylers Z Physiol Chem. 1967 Jul;348(7):843–851. [PubMed] [Google Scholar]
- LEVINE R. J., SATO T. L., SJOERDSMA A. INHIBITION OF HISTAMINE SYNTHESIS IN THE RAT BY ALPHA-HYDRAZINO ANALOG OF HISTIDINE AND 4-BROMO-3-HYDROXY BENZYLOXYAMINE. Biochem Pharmacol. 1965 Feb;14:139–149. doi: 10.1016/0006-2952(65)90069-9. [DOI] [PubMed] [Google Scholar]
- LOWRY O. H., ROSEBROUGH N. J., FARR A. L., RANDALL R. J. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951 Nov;193(1):265–275. [PubMed] [Google Scholar]
- Morris D. R., Pardee A. B. A biosynthetic ornithine decarboxylase in Escherichia coli. Biochem Biophys Res Commun. 1965 Sep 22;20(6):697–702. doi: 10.1016/0006-291x(65)90072-0. [DOI] [PubMed] [Google Scholar]
- Morris D. R., Pardee A. B. Multiple pathways of putrescine biosynthesis in Escherichia coli. J Biol Chem. 1966 Jul 10;241(13):3129–3135. [PubMed] [Google Scholar]
- RHODES J. B., WILLIAMS-ASHMAN H. G. OBSERVATIONS ON POLYAMINES IN MALE ACCESSORY GLANDS OF REPRODUCTION. Med Exp Int J Exp Med. 1964;10:281–285. doi: 10.1159/000135428. [DOI] [PubMed] [Google Scholar]
- Raina A., Cohen S. S. Polyamines and RNA synthesis in a polyauxotrophic strain of E. coli. Proc Natl Acad Sci U S A. 1966 Jun;55(6):1587–1593. doi: 10.1073/pnas.55.6.1587. [DOI] [PMC free article] [PubMed] [Google Scholar]
- SHUKUYA R., SCHWERT G. W. Glutamic acid decarboxylase. III. The inactivation of the enzyme at low temperatures. J Biol Chem. 1960 Jun;235:1658–1661. [PubMed] [Google Scholar]
- TABOR H., ROSENTHAL S. M., TABOR C. W. The biosynthesis of spermidine and spermine from putrescine and methionine. J Biol Chem. 1958 Oct;233(4):907–914. [PubMed] [Google Scholar]
- TABOR H., TABOR C. W. SPERMIDINE, SPERMINE, AND RELATED AMINES. Pharmacol Rev. 1964 Sep;16:245–300. [PubMed] [Google Scholar]
- Thompson J. S., Richardson K. E. Isolation and characterization of an L-alanine: glyoxylate aminotransferase from human liver. J Biol Chem. 1967 Aug 25;242(16):3614–3619. [PubMed] [Google Scholar]
- ZELLER E. A., VAN ORDEN L. S., VOGTLI W. Enzymology of mycobacteria. VII. Degradation of guanidine derivatives. J Biol Chem. 1954 Jul;209(1):429–435. [PubMed] [Google Scholar]