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. 1983 Jun;339:299–307. doi: 10.1113/jphysiol.1983.sp014717

The influence of pH on the healing-over of mammalian cardiac muscle.

W C De Mello
PMCID: PMC1199162  PMID: 6887024

Abstract

The process of healing-over was followed in trabeculae from the right ventricle of guinea-pigs and in Purkinje fibres from dogs by measuring resting potential and input resistance close to a site of damage. In Ca2+-free bathing solution at pH 6.5 no signs of healing-over were found; at pH 5.5 healing-over was incomplete; at pH 5.0 and 4.0 healing-over occurred promptly. It is concluded that transformation of low-resistance nexus membranes into high-resistance membranes separating the intracellular from the extracellular compartment normally is due to Ca2+, while protons can bring about the same effect under extreme conditions.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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