Skip to main content
NCBI home page
Biochemical Journal logoLink to Biochemical Journal
. 1964 Apr;91(1):35–42. doi: 10.1042/bj0910035

Cellular injury and carcinogenesis. Alkylation of ribonucleic acid of rat liver by diethylnitrosamine and n-butylmethylnitrosamine in vivo

P N Magee 1,*, K Y Lee 1
PMCID: PMC1202812  PMID: 5833387

Full text

PDF
35

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ALEXANDER P., STACEY K. A. Comparison of the changes produced by ionizing radiations and by the alkylating agents; evidence for a similar mechanism at the molecular level. Ann N Y Acad Sci. 1958 Apr 24;68(3):1225–1237. doi: 10.1111/j.1749-6632.1958.tb42685.x. [DOI] [PubMed] [Google Scholar]
  2. ARGUS M. F., HOCH-LIGETI C. Comparative study of the carcinogenic activity of nitrosamines. J Natl Cancer Inst. 1961 Sep;27:695–709. [PubMed] [Google Scholar]
  3. ARGUS M. F., HOCH-LIGETI C. Induction of malignant tumors in the guinea pig by oral administration of diethylnitrosamine. J Natl Cancer Inst. 1963 Mar;30:533–551. [PubMed] [Google Scholar]
  4. BARNES J. M., MAGEE P. N. Some toxic properties of dimethylnitrosamine. Br J Ind Med. 1954 Jul;11(3):167–174. doi: 10.1136/oem.11.3.167. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. BRUMM A. F., POTTER V. R., SIEKEVITZ P. Nucleotide metabolism. V. Incorporation of P32 into acid-soluble nucleotides of rat liver in vivo. J Biol Chem. 1956 Jun;220(2):713–722. [PubMed] [Google Scholar]
  6. BURCH P. R. Carcinogenesis and cancer prevention. Nature. 1963 Mar 23;197:1145–1151. doi: 10.1038/1971145a0. [DOI] [PubMed] [Google Scholar]
  7. Brookes P., Lawley P. D. The reaction of mono- and di-functional alkylating agents with nucleic acids. Biochem J. 1961 Sep;80(3):496–503. doi: 10.1042/bj0800496. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. CRADDOCK V. M., MAGEE P. N. REACTION OF THE CARCINOGEN DIMETHYLNITROSAMINE WITH NUCLEIC ACIDS IN VIVO. Biochem J. 1963 Oct;89:32–37. doi: 10.1042/bj0890032. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. DAVIDSON J. N., SMELLIE R. M. S. Phosphorus compounds in the cell. II. The separation by ionophoresis on paper of the constituent nucleotides of ribonucleic acid. Biochem J. 1952 Dec;52(4):594–599. doi: 10.1042/bj0520594. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. DONTENWILL W., MOHR U. [Carcinoma of the respiratory tract following treatment of the golden hamster with diethylnitrosamine]. Z Krebsforsch. 1961;64:305–312. [PubMed] [Google Scholar]
  11. EMMELOT P., MIZRAHI I. J. Counteraction by cysteine of glycogenolysis and inhibition of microsomal protein synthesis produced by dimethylnitrosamine. Nature. 1961 Oct 7;192:42–43. doi: 10.1038/192042a0. [DOI] [PubMed] [Google Scholar]
  12. EMMELOT P., MIZRAHI I. J., KRIEK E. Prevention by cysteamine of the inhibitory effect of carcinogenic N-nitrosodialkylamines on incorporation of amino-acids in rat liver. Nature. 1962 Mar 24;193:1158–1161. doi: 10.1038/1931158a0. [DOI] [PubMed] [Google Scholar]
  13. HEATH D. F. Mechanism of the hepatoxic action of dialkylnitrosamines. Nature. 1961 Oct 14;192:170–170. doi: 10.1038/192170a0. [DOI] [PubMed] [Google Scholar]
  14. HERROLD K. M., DUNHAM L. J. Induction of tumors in the Syrian hamster with diethylnitrosamine (N-nitrosodiethylamine). Cancer Res. 1963 Jun;23:773–777. [PubMed] [Google Scholar]
  15. HULTIN T., ARRHENIUS E., LOW H., MAGEE P. N. Toxic liver injury. Inhibition by dimethylnitrosamine of incorporation of labelled amino acids into proteins of rat-liver preparations in vitro. Biochem J. 1960 Jul;76:109–116. doi: 10.1042/bj0760109. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Heath D. F. The decomposition and toxicity of dialkylnitrosamines in rats. Biochem J. 1962 Oct;85(1):72–91. doi: 10.1042/bj0850072. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. KIRBY K. S. A new method for the isolation of ribonucleic acids from mammalian tissues. Biochem J. 1956 Nov;64(3):405–408. doi: 10.1042/bj0640405. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. MAGEE P. N., BARNES J. M. Induction of kidney tumours in the rat with dimethylnitrosamine (N-nitrosodimethylamine). J Pathol Bacteriol. 1962 Jul;84:19–31. doi: 10.1002/path.1700840103. [DOI] [PubMed] [Google Scholar]
  19. MAGEE P. N., BARNES J. M. The production of malignant primary hepatic tumours in the rat by feeding dimethylnitrosamine. Br J Cancer. 1956 Mar;10(1):114–122. doi: 10.1038/bjc.1956.15. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. MAGEE P. N., FARBER E. Toxic liver injury and carcinogenesis. Methylation of rat-liver nucleic acids by dimethylnitrosamine in vivo. Biochem J. 1962 Apr;83:114–124. doi: 10.1042/bj0830114. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. MAGEE P. N., HULTIN T. Toxic liver injury and carcinogenesis. Methylation of proteins of rat-liver slices by dimethylnitrosamine in vitro. Biochem J. 1962 Apr;83:106–114. doi: 10.1042/bj0830106. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. MARKHAM R., SMITH J. D. The structure of ribonucleic acid. I. Cyclic nucleotides produced by ribonuclease and by alkaline hydrolysis. Biochem J. 1952 Dec;52(4):552–557. doi: 10.1042/bj0520552. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. MIZRAHI I. J., EMMELOT P. The effect of cysteine on the metabolic changes produced by two carcinogenic Nnitrosodialklamines in rat liver. Cancer Res. 1962 Apr;22:339–351. [PubMed] [Google Scholar]
  24. PASTERNAK L. [Studies on the mutagenic effect of nitrosamines and nitrosomethylurea]. Acta Biol Med Ger. 1963;10:436–438. [PubMed] [Google Scholar]
  25. REINER B., ZAMENHOF S. Studies on the chemically reactive groups of deoxyribonucleic acids. J Biol Chem. 1957 Sep;228(1):475–486. [PubMed] [Google Scholar]
  26. THOMAS C. [On the morphology of diethylnitrosamine induced liver changes and tumors in rats]. Z Krebsforsch. 1961;64:224–233. [PubMed] [Google Scholar]
  27. WESTERGAARD M. Chemical mutagenesis in relation to the concept of the gene. Experientia. 1957 Jun 15;13(6):224–234. doi: 10.1007/BF02157427. [DOI] [PubMed] [Google Scholar]
  28. WYATT G. R. The purine and pyrimidine composition of deoxypentose nucleic acids. Biochem J. 1951 May;48(5):584–590. doi: 10.1042/bj0480584. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. ZAK F. G., HOLZNER J. H., SINGER E. J., POPPER H. Renal and pulmonary tumors in rats fed dimethylnitrosamine. Cancer Res. 1960 Jan;20:96–99. [PubMed] [Google Scholar]

Articles from Biochemical Journal are provided here courtesy of The Biochemical Society

RESOURCES