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. 1988 May;119(1):213–221. doi: 10.1093/genetics/119.1.213

Evolution of Bacterial Transformation: Is Sex with Dead Cells Ever Better than No Sex at All?

R J Redfield 1
PMCID: PMC1203342  PMID: 3396864

Abstract

Computer simulations of bacterial transformation are used to show that, under a wide range of biologically reasonable assumptions, transforming populations undergoing deleterious mutation and selection have a higher mean fitness at equilibrium than asexual populations. The source of transforming DNA, the amount of DNA taken up by each transforming cell, and the relationship between number of mutations and cell viability (the fitness function) are important factors. When the DNA source is living cells, transformation resembles meiotic sex. When the DNA source is cells killed by selection against mutations, transformation increases the average number of mutations per genome but can nevertheless increase the mean fitness of the population at equilibrium. In a model of regulated transformation, in which the most fit cells of a transforming population do not transform, transforming populations are always fitter at equilibrium than asexual populations. These results show that transformation can reduce mutation load.

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Selected References

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  1. Caugant D. A., Mocca L. F., Frasch C. E., Frøholm L. O., Zollinger W. D., Selander R. K. Genetic structure of Neisseria meningitidis populations in relation to serogroup, serotype, and outer membrane protein pattern. J Bacteriol. 1987 Jun;169(6):2781–2792. doi: 10.1128/jb.169.6.2781-2792.1987. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Charlesworth B. Recombination modification in a flucturating environment. Genetics. 1976 May;83(1):181–195. doi: 10.1093/genetics/83.1.181. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Cox E. C. Bacterial mutator genes and the control of spontaneous mutation. Annu Rev Genet. 1976;10:135–156. doi: 10.1146/annurev.ge.10.120176.001031. [DOI] [PubMed] [Google Scholar]
  4. Dykhuizen D. E., Dean A. M., Hartl D. L. Metabolic flux and fitness. Genetics. 1987 Jan;115(1):25–31. doi: 10.1093/genetics/115.1.25. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Eshel I., Feldman M. W. On the evolutionary effect of recombination. Theor Popul Biol. 1970 May;1(1):88–100. doi: 10.1016/0040-5809(70)90043-2. [DOI] [PubMed] [Google Scholar]
  6. Gottesman S. Bacterial regulation: global regulatory networks. Annu Rev Genet. 1984;18:415–441. doi: 10.1146/annurev.ge.18.120184.002215. [DOI] [PubMed] [Google Scholar]
  7. Haigh J. The accumulation of deleterious genes in a population--Muller's Ratchet. Theor Popul Biol. 1978 Oct;14(2):251–267. doi: 10.1016/0040-5809(78)90027-8. [DOI] [PubMed] [Google Scholar]
  8. Kondrashov A. S. Deleterious mutations as an evolutionary factor. 1. The advantage of recombination. Genet Res. 1984 Oct;44(2):199–217. doi: 10.1017/s0016672300026392. [DOI] [PubMed] [Google Scholar]
  9. Kondrashov A. S. Selection against harmful mutations in large sexual and asexual populations. Genet Res. 1982 Dec;40(3):325–332. doi: 10.1017/s0016672300019194. [DOI] [PubMed] [Google Scholar]
  10. Low K. B., Porter D. D. Modes of gene transfer and recombination in bacteria. Annu Rev Genet. 1978;12:249–287. doi: 10.1146/annurev.ge.12.120178.001341. [DOI] [PubMed] [Google Scholar]
  11. MULLER H. J. THE RELATION OF RECOMBINATION TO MUTATIONAL ADVANCE. Mutat Res. 1964 May;106:2–9. doi: 10.1016/0027-5107(64)90047-8. [DOI] [PubMed] [Google Scholar]
  12. Michod R. E., Wojciechowski M. F., Hoelzer M. A. DNA repair and the evolution of transformation in the bacterium Bacillus subtilis. Genetics. 1988 Jan;118(1):31–39. doi: 10.1093/genetics/118.1.31. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Musser J. M., Granoff D. M., Pattison P. E., Selander R. K. A population genetic framework for the study of invasive diseases caused by serotype b strains of Haemophilus influenzae. Proc Natl Acad Sci U S A. 1985 Aug;82(15):5078–5082. doi: 10.1073/pnas.82.15.5078. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Setlow J. K., Boling M. E., Allison D. P., Beattie K. L. Relationship between prophage induction and transformation in Haemophilus influenzae. J Bacteriol. 1973 Jul;115(1):153–161. doi: 10.1128/jb.115.1.153-161.1973. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Sinha R. P., Iyer V. N. Competence for genetic transformation and the release of DNA from Bacillus subtilis. Biochim Biophys Acta. 1971 Feb 25;232(1):61–71. doi: 10.1016/0005-2787(71)90491-6. [DOI] [PubMed] [Google Scholar]
  16. Smith H. O., Danner D. B., Deich R. A. Genetic transformation. Annu Rev Biochem. 1981;50:41–68. doi: 10.1146/annurev.bi.50.070181.000353. [DOI] [PubMed] [Google Scholar]
  17. Stewart G. J., Carlson C. A. The biology of natural transformation. Annu Rev Microbiol. 1986;40:211–235. doi: 10.1146/annurev.mi.40.100186.001235. [DOI] [PubMed] [Google Scholar]
  18. Walker G. C. Inducible DNA repair systems. Annu Rev Biochem. 1985;54:425–457. doi: 10.1146/annurev.bi.54.070185.002233. [DOI] [PubMed] [Google Scholar]

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