Abstract
The phenomenon of genomic imprinting has recently excited much interest among experimental biologists. The population genetic consequences of imprinting, however, have remained largely unexplored. Several population genetic models are presented and the following conclusions drawn: (i) systems with genomic imprinting need not behave similarly to otherwise identical systems without imprinting; (ii) nevertheless, many of the models investigated can be shown to be formally equivalent to models without imprinting; (iii) consequently, imprinting often cannot be discovered by following allele frequency changes or examining equilibrium values; (iv) the formal equivalences fail to preserve some well known properties. For example, for populations incorporating genomic imprinting, parameter values exist that cause these populations to behave like populations without imprinting, but with heterozygote advantage, even though no such advantage is present in these imprinting populations. We call this last phenomenon ``pseudoheterosis.'' The imprinting systems that fail to be formally equivalent to nonimprinting systems are those in which males and females are not equivalent, i.e., two-sex viability systems and sex-chromosome inactivation.
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Selected References
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- Bodmer W F. Differential Fertility in Population Genetics Models. Genetics. 1965 Mar;51(3):411–424. doi: 10.1093/genetics/51.3.411. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Chakraborty R. Can molecular imprinting explain heterozygote deficiency and hybrid vigor? Genetics. 1989 Jul;122(3):713–717. doi: 10.1093/genetics/122.3.713. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Denniston C., Crow J. F. Alternative fitness models with the same allele frequency dynamics. Genetics. 1990 May;125(1):201–205. doi: 10.1093/genetics/125.1.201. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Feldman M. W., Christiansen F. B., Liberman U. On some models of fertility selection. Genetics. 1983 Dec;105(4):1003–1010. doi: 10.1093/genetics/105.4.1003. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hadchouel M., Farza H., Simon D., Tiollais P., Pourcel C. Maternal inhibition of hepatitis B surface antigen gene expression in transgenic mice correlates with de novo methylation. Nature. 1987 Oct 1;329(6138):454–456. doi: 10.1038/329454a0. [DOI] [PubMed] [Google Scholar]
- Hall J. G. Genomic imprinting: review and relevance to human diseases. Am J Hum Genet. 1990 May;46(5):857–873. [PMC free article] [PubMed] [Google Scholar]
- Hines W. G. Evolutionarily [corrected] stable strategies: a review of basic theory. Theor Popul Biol. 1987 Apr;31(2):195–272. doi: 10.1016/0040-5809(87)90029-3. [DOI] [PubMed] [Google Scholar]
- MANDEL S. P. Stable equilibrium at a sex-linked locus. Nature. 1959 May 9;183(4671):1347–1348. doi: 10.1038/1831347a0. [DOI] [PubMed] [Google Scholar]
- Marx J. L. A parent's sex may affect gene expression. Science. 1988 Jan 22;239(4838):352–353. doi: 10.1126/science.3336789. [DOI] [PubMed] [Google Scholar]
- Reik W., Collick A., Norris M. L., Barton S. C., Surani M. A. Genomic imprinting determines methylation of parental alleles in transgenic mice. Nature. 1987 Jul 16;328(6127):248–251. doi: 10.1038/328248a0. [DOI] [PubMed] [Google Scholar]
- Sapienza C., Peterson A. C., Rossant J., Balling R. Degree of methylation of transgenes is dependent on gamete of origin. Nature. 1987 Jul 16;328(6127):251–254. doi: 10.1038/328251a0. [DOI] [PubMed] [Google Scholar]
- Solter D. Differential imprinting and expression of maternal and paternal genomes. Annu Rev Genet. 1988;22:127–146. doi: 10.1146/annurev.ge.22.120188.001015. [DOI] [PubMed] [Google Scholar]
- Swain J. L., Stewart T. A., Leder P. Parental legacy determines methylation and expression of an autosomal transgene: a molecular mechanism for parental imprinting. Cell. 1987 Aug 28;50(5):719–727. doi: 10.1016/0092-8674(87)90330-8. [DOI] [PubMed] [Google Scholar]