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. 1996 Mar 1;314(Pt 2):401–404. doi: 10.1042/bj3140401

Activation of a protein tyrosine phosphatase and inactivation of Raf-1 by somatostatin.

D B Reardon 1, S L Wood 1, D L Brautigan 1, G I Bell 1, P Dent 1, T W Sturgill 1
PMCID: PMC1217062  PMID: 8670047

Abstract

Human somatostatin receptor 3 ('hsstr3') was transiently expressed in NIH 3T3 cells stably transformed with Ha-Ras (G12V). Somatostatin activated a protein tyrosine phosphatase and inactivated the constitutively active, membrane-associated form of the Raf-1 serine kinase present in these cells in vivo and in vitro.

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Selected References

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