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. 2002 Dec 15;368(Pt 3):673–677. doi: 10.1042/BJ20021587

Cloning and characterization of multiple human polyamine oxidase splice variants that code for isoenzymes with different biochemical characteristics.

Tracy Murray-Stewart 1, Yanlin Wang 1, Wendy Devereux 1, Robert A Casero Jr 1
PMCID: PMC1223052  PMID: 12398765

Abstract

The recently cloned and characterized human polyamine oxidase (PAOh1) potentially represents a new class of catabolic enzymes in the mammalian polyamine metabolic pathway capable of the efficient oxidation of polyamines. Here the discovery of three additional human PAO splice variants is reported, and the data support the fact that the human PAO gene codes for at least four isoenzymes, each of which exhibit distinctive biochemical characteristics, suggesting the existence of additional levels of complexity in polyamine catabolism.

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Selected References

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