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. 2003 Mar 1;370(Pt 2):361–371. doi: 10.1042/BJ20021626

Regulation of the ABC kinases by phosphorylation: protein kinase C as a paradigm.

Alexandra C Newton 1
PMCID: PMC1223206  PMID: 12495431

Abstract

Phosphorylation plays a central role in regulating the activation and signalling lifetime of protein kinases A, B (also known as Akt) and C. These kinases share three conserved phosphorylation motifs: the activation loop segment, the turn motif and the hydrophobic motif. This review focuses on how phosphorylation at each of these sites regulates the maturation, signalling and down-regulation of PKC as a paradigm for how these sites control the function of the ABC kinases.

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Selected References

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