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. 1982;329:57–73. doi: 10.1113/jphysiol.1982.sp014290

The pH oscillations in arterial blood during exercise; a potential signal for the ventilatory response in the dog

Brenda A Cross *,†,‡, A Davey *,†,‡, A Guz *,†,‡, P G Katona *, M Maclean *,†,‡, K Murphy *,†,‡, S J G Semple *,†,‡, R Stidwill *,†,‡
PMCID: PMC1224767  PMID: 6815323

Abstract

1. The effect of electrically induced `exercise' on the respiratory oscillation of arterial pH was studied in chloralose-anaesthetized dogs with spinal cord transection at T8/9 (dermatome level T6/7).

2. Respiratory oscillations of arterial pH (presumed to be due to oscillations of arterial PCO2) were sensed with a fast-responding electrode in one carotid artery. Breath-by-breath estimates of the maximum rate of change of pH of the downstroke of the pH oscillation (dpH/dt↓max) were obtained by differentiating the pH signal.

3. Consistent with the findings of the previous paper (Cross et al. 1982), the ventilatory response to exercise could not be explained on the basis of sensitivity to CO2; the Δ˙VI/ΔPa, CO2 was significantly greater for `exercise' than for CO2 inhalation.

4. On average, the amplitude of the pH oscillations decreased during `exercise'. The change in the phase relationship (ϕ) between respiratory and pH cycles, although significant from the second breath onwards, was not thought to be responsible for the increased ventilation ˙VI; the direction of the change was opposite to that previously found to increase ˙VI.

5. Inspiratory duration (ti), expiratory duration (te), ˙VI and the dpH/dt↓max changed significantly by the third breath of `exercise'. A significantly linear relationship was obtained between te and dpH/dt↓max during the on-transient (first ten breaths) of `exercise'. This relationship was maintained throughout `exercise'. ˙VI and dpH/dt↓max were also linearly related during the on-transient, although the same relationship did not hold true throughout `exercise'.

6. The dpH/dt↓max was related to CO2 production (˙VCO2) lending support to the prediction that the slope of the downstroke of the pH oscillation is a function of ˙VCO2.

7. It was concluded that the dpH/dt↓max (dpCO2/dt↑max) is a potential humoral signal in `exercise' and could account totally for the shortening of te. Since there was a late rise in ˙VI (due to an increase in tidal volume VT) in the absence of a change in dpH/dt↓max, it was considered unlikely that the dpH/dt↓max was the only humoral signal present during `exercise'.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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