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. 1982 Sep;330:489–496. doi: 10.1113/jphysiol.1982.sp014354

Effect of pancreatic juice on basal pancreatic and gastric secretion in dogs.

D F Magee, S Naruse
PMCID: PMC1225311  PMID: 7175754

Abstract

1. The effect of duodenal infusion of pancreatic juice on basal pancreatic and gastric secretion was studied in five conscious dogs provided with pancreatic fistulae, gastric fistulae and Heidenhain fundic pouches. 2. Pancreatic juice and trypsin stimulated a pancreatic secretion rich in protein. 3. Autodigested juice without proteolytic activities also stimulated the secretion. Boiling the juice or addition of trypsin inhibitor to the juice diminished the augmented secretion. 4. It seems, therefore, that trypsin is necessary even in proteolytically inactive autodigested juice for pancreatic stimulation. 5. In dogs, unlike rats and pigs, basal pancreatic secretion is not under negative feed-back control by duodenal tryptic activity. 6. Basal gastric secretion was not significantly changed by duodenal infusion of pancreatic juice.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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