Skip to main content
PMC home page
Canadian Journal of Comparative Medicine logoLink to Canadian Journal of Comparative Medicine
. 1983 Jul;47(3):250–256.

Prevention of experimental bovine pneumonic pasteurellosis with an extract of Pasteurella haemolytica.

W D Yates, P H Stockdale, L A Babiuk, R J Smith
PMCID: PMC1235934  PMID: 6315195

Abstract

A total of 36 calves were used in three experiments to test the efficacy of a potassium thiocyanate extract of Pasteurella haemolytica in protecting against experimental pneumonia. In each of experiments A and B, 12 calves were divided into three equal groups. The first group was vaccinated with an aerosol of a potassium thiocyanate extract twice, two weeks apart; the second group was vaccinated subcutaneously once only with the same extract. The third group of calves in both experiments remained as unvaccinated controls. In experiment C, six calves were vaccinated intramuscularly and six were left as controls. Approximately one month after vaccination all calves were challenged with an aerosol of bovine herpesvirus 1 (isolate 108) followed in 4 d by an aerosol of P. haemolytica type A1 (the same strain from which the potassium thiocyanate extract had been made). Varying degrees of protection against subsequent development of experimental pneumonic pasteurellosis in cattle were seen in vaccinated calves as compared to control calves in these experiments. The results indicate that protection of cattle against pneumonic pasteurellosis may prove possible with a sub-cellular extract of P. haemolytica.

Full text

PDF
252

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Andrews B. E., Leach R. H., Gourlay R. N., Howard C. J. Enhanced isolation of Mycoplasma dispar by substitution of ampicillin for benzylpenicillin in growth media. Vet Rec. 1973 Dec 8;93(23):603–603. doi: 10.1136/vr.93.23.603-a. [DOI] [PubMed] [Google Scholar]
  2. Babiuk L. A., Wardley R. C., Rouse B. T. Defense mechanisms against bovine herpesvirus: relationship of virus-host cell events to susceptibility to antibody-complement cell lysis. Infect Immun. 1975 Nov;12(5):958–963. doi: 10.1128/iai.12.5.958-963.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Friend S. C., Wilkie B. N., Thomson R. G., Barnum D. A. Bovine pneumonic pasteurellosis: experimental induction in vaccinated and nonvaccinated calves. Can J Comp Med. 1977 Jan;41(1):77–83. [PMC free article] [PubMed] [Google Scholar]
  4. Gilmour N. J., Martin W. B., Sharp J. M., Thompson D. A., Wells P. W. The development of vaccines against pneumonic pasteurellosis in sheep. Vet Rec. 1979 Jan 6;104(1):15–15. doi: 10.1136/vr.104.1.15. [DOI] [PubMed] [Google Scholar]
  5. Gourlay R. N., Leach R. H. A new mycoplasma species isolated from pneumonic lungs of calves (Mycoplasma dispar sp. nov.). J Med Microbiol. 1970 Feb;3(1):111–123. doi: 10.1099/00222615-3-1-111. [DOI] [PubMed] [Google Scholar]
  6. Hayflick L. Tissue cultures and mycoplasmas. Tex Rep Biol Med. 1965 Jun;23(Suppl):285+–285+. [PubMed] [Google Scholar]
  7. Jakab G. J., Dick E. C. Synergistic effect in viral-bacterial infection: combined infection of the murine respiratory tract with Sendai virus and Pasteurella pneumotropica. Infect Immun. 1973 Nov;8(5):762–768. doi: 10.1128/iai.8.5.762-768.1973. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Jakab G. J., Green G. M. Immune enhancement of pulmonary bactericidal activity in murine virus pneumonia. J Clin Invest. 1973 Nov;52(11):2878–2884. doi: 10.1172/JCI107484. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Jericho K. W., Langford E. V. Pneumonia in calves produced with aerosols of bovine herpesvirus 1 and Pasteurella haemolytica. Can J Comp Med. 1978 Jul;42(3):269–277. [PMC free article] [PubMed] [Google Scholar]
  10. Jericho K. W., Magwood S. E., Stockdale P. H. Letter to the editor: Prevention of experimental bovine pneumonic pasteurellosis by exposure to IBR virus. Can Vet J. 1976 Jul;17(7):194–195. [PMC free article] [PubMed] [Google Scholar]
  11. Muenster O. A., Ose E. E., Matsuoka T. The incidence of Mycoplasma dispar, Ureaplasma and conventional Mycoplasma in the pneumonic calf lung. Can J Comp Med. 1979 Oct;43(4):392–398. [PMC free article] [PubMed] [Google Scholar]
  12. Mukkur T. K. Immunogenicity of a chaotropically extracted protective antigen(s) of Pasteurella multocida type A (bovine origin) against experimental pasteurellosis in mice. J Gen Microbiol. 1979 Jul;113(1):37–43. doi: 10.1099/00221287-113-1-37. [DOI] [PubMed] [Google Scholar]
  13. Shepard M. C., Lunceford C. D. Differential agar medium (A7) for identification of Ureaplasma urealyticum (human T mycoplasmas) in primary cultures of clinical material. J Clin Microbiol. 1976 Jun;3(6):613–625. doi: 10.1128/jcm.3.6.613-625.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Shroyer E. L., Easterday B. C. Studies on the pathogenesis of infectious bovine rhinotracheitis following aerosol exposure. Cornell Vet. 1968 Jul;58(3):442–461. [PubMed] [Google Scholar]
  15. Stockdale P. H., Jericho K. W., Yates W. D., Darcel C., Langford E. V. Experimental bovine pneumonic pasteurellosis. II. Genesis and prevention. Can J Comp Med. 1979 Jul;43(3):272–279. [PMC free article] [PubMed] [Google Scholar]
  16. Stockdale P. H., Langford E. V., Darcel C. Experimental bovine pneumonic pasteurellosis. I. Prevention of the disease. Can J Comp Med. 1979 Jul;43(3):262–271. [PMC free article] [PubMed] [Google Scholar]
  17. Wells P. W., Sharp J. M., Rushton B., Gilmour N. J., Thompson D. A. The effect of vaccination with a parainfluenza type 3 virus on pneumonia resulting from infection with parainfluenza type 3 virus and Pasteurella haemolytica. J Comp Pathol. 1978 Apr;88(2):253–259. doi: 10.1016/0021-9975(78)90029-4. [DOI] [PubMed] [Google Scholar]
  18. Wilkie B. N., Markham R. J. Sequential titration of bovine lung and serum antibodies after parenteral or pulmonary inoculation with Pasteurella haemolytica. Am J Vet Res. 1979 Dec;40(12):1690–1693. [PubMed] [Google Scholar]
  19. Wilkie B. N., Markham R. J., Shewen P. E. Response of calves to lung challenge exposure with Pasteurella haemolytica after parenteral or pulmonary immunization. Am J Vet Res. 1980 Nov;41(11):1773–1778. [PubMed] [Google Scholar]

Articles from Canadian Journal of Comparative Medicine are provided here courtesy of Canadian Veterinary Medical Association

RESOURCES