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. 1977 Jan;126(1):5–13.

Intravenous and Intrathecal Miconazole Therapy for Systemic Mycoses

James P Sung 1,2, Jan G Grendahl 1,2, H B Levine 1,2
PMCID: PMC1237424  PMID: 576177

Abstract

Ten patients with systemic mycoses, including five with fungal meningitis, were treated with intravenously or intrathecally administered miconazole, or both. Minimal inhibitory concentrations of miconazole for clinical isolates of Coccidioides immitis, Cryptococcus neoformans and Candida albicans were less than 0.6 µg per ml. Except for pruritis of variable degrees, the drug was well tolerated both intravenously and intrathecally by all patients. No measurable impairment of renal, hepatic or bone marrow function was observed in patients after 4½ months of intravenous therapy. No hematological or biochemical abnormalities and no evidence of recurrent coccidioidal osteomyelitis were observed in 16 months of follow-up in our first patient treated with this drug. Miconazole is apparently an effective antifungal drug of low toxicity and is a potentially useful agent for treatment of human systemic mycoses.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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