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. 2003 Jan;111(1):65–70. doi: 10.1289/ehp.5463

Comparison of polychlorinated biphenyl levels across studies of human neurodevelopment.

Matthew P Longnecker 1, Mary S Wolff 1, Beth C Gladen 1, John W Brock 1, Philippe Grandjean 1, Joseph L Jacobson 1, Susan A Korrick 1, Walter J Rogan 1, Nynke Weisglas-Kuperus 1, Irva Hertz-Picciotto 1, Pierre Ayotte 1, Paul Stewart 1, Gerhard Winneke 1, M Judith Charles 1, Sandra W Jacobson 1, Eric Dewailly 1, E Rudy Boersma 1, Larisa M Altshul 1, Birger Heinzow 1, James J Pagano 1, Allan A Jensen 1
PMCID: PMC1241307  PMID: 12515680

Abstract

Polychlorinated biphenyls (PCBs) are persistent pollutants that are ubiquitous in the food chain, and detectable amounts are in the blood of almost every person in most populations that have been examined. Extensive evidence from animal studies shows that PCBs are neurotoxins, even at low doses. Interpretation of human data regarding low-level, early-life PCB exposure and subsequent neurodevelopment is problematic because levels of exposure were not similarly quantified across studies. We expressed the exposure levels from 10 studies of PCB and neurodevelopment in a uniform manner using a combination of data from original investigators, laboratory reanalyses, calculations based on published data, and expert opinion. The mainstay of our comparison was the median level of PCB 153 in maternal pregnancy serum. The median concentration of PCB 153 in the 10 studies ranged from 30 to 450 ng/g serum lipid, and the median of the 10 medians was 110 ng/g. We found that (a)) the distribution of PCB 153 exposure in most studies overlapped substantially, (b)) exposure levels in the Faroe Islands study were about 3-4-fold higher than in most other studies, and (c)) the exposure levels in the two recent U.S. studies were about one-third of those in the four earlier U.S. studies or recent Dutch, German, and northern Québec studies. Our results will facilitate a direct comparison of the findings on PCBs and neurodevelopment when they are published for all 10 studies.

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Selected References

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  1. Brock J. W., Burse V. W., Ashley D. L., Najam A. R., Green V. E., Korver M. P., Powell M. K., Hodge C. C., Needham L. L. An improved analysis for chlorinated pesticides and polychlorinated biphenyls (PCBs) in human and bovine sera using solid-phase extraction. J Anal Toxicol. 1996 Nov-Dec;20(7):528–536. doi: 10.1093/jat/20.7.528. [DOI] [PubMed] [Google Scholar]
  2. Brouwer A., Longnecker M. P., Birnbaum L. S., Cogliano J., Kostyniak P., Moore J., Schantz S., Winneke G. Characterization of potential endocrine-related health effects at low-dose levels of exposure to PCBs. Environ Health Perspect. 1999 Aug;107 (Suppl 4):639–649. doi: 10.1289/ehp.99107s4639. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Darvill T., Lonky E., Reihman J., Stewart P., Pagano J. Prenatal exposure to PCBs and infant performance on the fagan test of infant intelligence. Neurotoxicology. 2000 Dec;21(6):1029–1038. [PubMed] [Google Scholar]
  4. DeVoto E., Fiore B. J., Millikan R., Anderson H. A., Sheldon L., Sonzogni W. C., Longnecker M. P. Correlations among human blood levels of specific PCB congeners and implications for epidemiologic studies. Am J Ind Med. 1997 Dec;32(6):606–613. doi: 10.1002/(sici)1097-0274(199712)32:6<606::aid-ajim6>3.0.co;2-n. [DOI] [PubMed] [Google Scholar]
  5. Gladen B. C., Longnecker M. P., Schecter A. J. Correlations among polychlorinated biphenyls, dioxins, and furans in humans. Am J Ind Med. 1999 Jan;35(1):15–20. doi: 10.1002/(sici)1097-0274(199901)35:1<15::aid-ajim3>3.0.co;2-z. [DOI] [PubMed] [Google Scholar]
  6. Gladen B. C., Rogan W. J. Effects of perinatal polychlorinated biphenyls and dichlorodiphenyl dichloroethene on later development. J Pediatr. 1991 Jul;119(1 Pt 1):58–63. doi: 10.1016/s0022-3476(05)81039-x. [DOI] [PubMed] [Google Scholar]
  7. Glynn A. W., Wolk A., Aune M., Atuma S., Zettermark S., Maehle-Schmid M., Darnerud P. O., Becker W., Vessby B., Adami H. O. Serum concentrations of organochlorines in men: a search for markers of exposure. Sci Total Environ. 2000 Dec 18;263(1-3):197–208. doi: 10.1016/s0048-9697(00)00703-8. [DOI] [PubMed] [Google Scholar]
  8. Grandjean P., Weihe P., Burse V. W., Needham L. L., Storr-Hansen E., Heinzow B., Debes F., Murata K., Simonsen H., Ellefsen P. Neurobehavioral deficits associated with PCB in 7-year-old children prenatally exposed to seafood neurotoxicants. Neurotoxicol Teratol. 2001 Jul-Aug;23(4):305–317. doi: 10.1016/s0892-0362(01)00155-6. [DOI] [PubMed] [Google Scholar]
  9. Grimvall E., Rylander L., Nilsson-Ehle P., Nilsson U., Strömberg U., Hagmar L., Ostman C. Monitoring of polychlorinated biphenyls in human blood plasma: methodological developments and influence of age, lactation, and fish consumption. Arch Environ Contam Toxicol. 1997 Apr;32(3):329–336. doi: 10.1007/s002449900193. [DOI] [PubMed] [Google Scholar]
  10. Hagmar L., Rylander L., Dyremark E., Klasson-Wehler E., Erfurth E. M. Plasma concentrations of persistent organochlorines in relation to thyrotropin and thyroid hormone levels in women. Int Arch Occup Environ Health. 2001 Apr;74(3):184–188. doi: 10.1007/s004200000213. [DOI] [PubMed] [Google Scholar]
  11. Jacobson J. L., Humphrey H. E., Jacobson S. W., Schantz S. L., Mullin M. D., Welch R. Determinants of polychlorinated biphenyls (PCBs), polybrominated biphenyls (PBBs), and dichlorodiphenyl trichloroethane (DDT) levels in the sera of young children. Am J Public Health. 1989 Oct;79(10):1401–1404. doi: 10.2105/ajph.79.10.1401. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Jacobson J. L., Jacobson S. W. Intellectual impairment in children exposed to polychlorinated biphenyls in utero. N Engl J Med. 1996 Sep 12;335(11):783–789. doi: 10.1056/NEJM199609123351104. [DOI] [PubMed] [Google Scholar]
  13. James Rebecca A., Hertz-Picciotto Irva, Willman Eric, Keller Jean A., Charles M. Judith. Determinants of serum polychlorinated biphenyls and organochlorine pesticides measured in women from the child health and development study cohort, 1963-1967. Environ Health Perspect. 2002 Jul;110(7):617–624. doi: 10.1289/ehp.02110617. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Jensen A. A. Polychlorobiphenyls (PCBs), polychlorodibenzo-p-dioxins (PCDDs) and polychlorodibenzofurans (PCDFs) in human milk, blood and adipose tissue. Sci Total Environ. 1987 Jul;64(3):259–293. doi: 10.1016/0048-9697(87)90250-6. [DOI] [PubMed] [Google Scholar]
  15. Korrick S. A., Altshul L. M., Tolbert P. E., Burse V. W., Needham L. L., Monson R. R. Measurement of PCBs, DDE, and hexachlorobenzene in cord blood from infants born in towns adjacent to a PCB-contaminated waste site. J Expo Anal Environ Epidemiol. 2000 Nov-Dec;10(6 Pt 2):743–754. doi: 10.1038/sj.jea.7500120. [DOI] [PubMed] [Google Scholar]
  16. Laden F., Collman G., Iwamoto K., Alberg A. J., Berkowitz G. S., Freudenheim J. L., Hankinson S. E., Helzlsouer K. J., Holford T. R., Huang H. Y. 1,1-Dichloro-2,2-bis(p-chlorophenyl)ethylene and polychlorinated biphenyls and breast cancer: combined analysis of five U.S. studies. J Natl Cancer Inst. 2001 May 16;93(10):768–776. doi: 10.1093/jnci/93.10.768. [DOI] [PubMed] [Google Scholar]
  17. Longnecker M. P., Gladen B. C., Patterson D. G., Jr, Rogan W. J. Polychlorinated biphenyl (PCB) exposure in relation to thyroid hormone levels in neonates. Epidemiology. 2000 May;11(3):249–254. doi: 10.1097/00001648-200005000-00004. [DOI] [PubMed] [Google Scholar]
  18. Longnecker M. P., Klebanoff M. A., Brock J. W., Zhou H., Collaborative Perinatal Project (CPP) Polychlorinated biphenyl serum levels in pregnant subjects with diabetes. Diabetes Care. 2001 Jun;24(6):1099–1101. doi: 10.2337/diacare.24.6.1099. [DOI] [PubMed] [Google Scholar]
  19. Longnecker M. P., Ryan J. J., Gladen B. C., Schecter A. J. Correlations among human plasma levels of dioxin-like compounds and polychlorinated biphenyls (PCBs) and implications for epidemiologic studies. Arch Environ Health. 2000 May-Jun;55(3):195–200. doi: 10.1080/00039890009603406. [DOI] [PubMed] [Google Scholar]
  20. McKinney J. D., Moore L., Prokopetz A., Walters D. B. Validated extraction and cleanup procedures for polychlorinated biphenyls and DDE in human body fluids and infant formula. J Assoc Off Anal Chem. 1984 Jan-Feb;67(1):122–129. [PubMed] [Google Scholar]
  21. Mohammed A., Eklund A., Ostlund-Lindqvist A. M., Slanina P. Distribution of toxaphene, DDT, and PCB among lipoprotein fractions in rat and human plasma. Arch Toxicol. 1990;64(7):567–571. doi: 10.1007/BF01971836. [DOI] [PubMed] [Google Scholar]
  22. Muckle G., Ayotte P., Dewailly E E., Jacobson S. W., Jacobson J. L. Prenatal exposure of the northern Québec Inuit infants to environmental contaminants. Environ Health Perspect. 2001 Dec;109(12):1291–1299. doi: 10.1289/ehp.011091291. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Norén K., Weistrand C., Karpe F. Distribution of PCB congeners, DDE, hexachlorobenzene, and methylsulfonyl metabolites of PCB and DDE among various fractions of human blood plasma. Arch Environ Contam Toxicol. 1999 Oct;37(3):408–414. doi: 10.1007/s002449900532. [DOI] [PubMed] [Google Scholar]
  24. Patandin S., Lanting C. I., Mulder P. G., Boersma E. R., Sauer P. J., Weisglas-Kuperus N. Effects of environmental exposure to polychlorinated biphenyls and dioxins on cognitive abilities in Dutch children at 42 months of age. J Pediatr. 1999 Jan;134(1):33–41. doi: 10.1016/s0022-3476(99)70369-0. [DOI] [PubMed] [Google Scholar]
  25. Pauwels A., Covaci A., Weyler J., Delbeke L., Dhont M., De Sutter P., D'Hooghe T., Schepens P. J. Comparison of persistent organic pollutant residues in serum and adipose tissue in a female population in Belgium, 1996-1998. Arch Environ Contam Toxicol. 2000 Aug;39(2):265–270. doi: 10.1007/s002440010104. [DOI] [PubMed] [Google Scholar]
  26. Phillips D. L., Pirkle J. L., Burse V. W., Bernert J. T., Jr, Henderson L. O., Needham L. L. Chlorinated hydrocarbon levels in human serum: effects of fasting and feeding. Arch Environ Contam Toxicol. 1989 Jul-Aug;18(4):495–500. doi: 10.1007/BF01055015. [DOI] [PubMed] [Google Scholar]
  27. Rice D. C. Behavioral impairment produced by low-level postnatal PCB exposure in monkeys. Environ Res. 1999 Feb;80(2 Pt 2):S113–S121. doi: 10.1006/enrs.1998.3917. [DOI] [PubMed] [Google Scholar]
  28. Rogan W. J., Gladen B. C., Hung K. L., Koong S. L., Shih L. Y., Taylor J. S., Wu Y. C., Yang D., Ragan N. B., Hsu C. C. Congenital poisoning by polychlorinated biphenyls and their contaminants in Taiwan. Science. 1988 Jul 15;241(4863):334–336. doi: 10.1126/science.3133768. [DOI] [PubMed] [Google Scholar]
  29. Rogan W. J., Gladen B. C., McKinney J. D., Carreras N., Hardy P., Thullen J., Tingelstad J., Tully M. Polychlorinated biphenyls (PCBs) and dichlorodiphenyl dichloroethene (DDE) in human milk: effects of maternal factors and previous lactation. Am J Public Health. 1986 Feb;76(2):172–177. doi: 10.2105/ajph.76.2.172. [DOI] [PMC free article] [PubMed] [Google Scholar]
  30. Rogan W. J., Gladen B. C., McKinney J. D., Carreras N., Hardy P., Thullen J., Tinglestad J., Tully M. Neonatal effects of transplacental exposure to PCBs and DDE. J Pediatr. 1986 Aug;109(2):335–341. doi: 10.1016/s0022-3476(86)80397-3. [DOI] [PubMed] [Google Scholar]
  31. Schoula R., Hajslová J., Bencko V., Poustka J., Holadová K., Vízek V. Occurrence of persistent organochlorine contaminants in human milk collected in several regions of Czech Republic. Chemosphere. 1996 Oct;33(8):1485–1494. doi: 10.1016/0045-6535(96)00287-1. [DOI] [PubMed] [Google Scholar]
  32. Schwartz P. M., Jacobson S. W., Fein G., Jacobson J. L., Price H. A. Lake Michigan fish consumption as a source of polychlorinated biphenyls in human cord serum, maternal serum, and milk. Am J Public Health. 1983 Mar;73(3):293–296. doi: 10.2105/ajph.73.3.293. [DOI] [PMC free article] [PubMed] [Google Scholar]
  33. Seegal R. F. Epidemiological and laboratory evidence of PCB-induced neurotoxicity. Crit Rev Toxicol. 1996 Nov;26(6):709–737. doi: 10.3109/10408449609037481. [DOI] [PubMed] [Google Scholar]
  34. Steuerwald U., Weihe P., Jørgensen P. J., Bjerve K., Brock J., Heinzow B., Budtz-Jørgensen E., Grandjean P. Maternal seafood diet, methylmercury exposure, and neonatal neurologic function. J Pediatr. 2000 May;136(5):599–605. doi: 10.1067/mpd.2000.102774. [DOI] [PubMed] [Google Scholar]
  35. Tilson H. A., Jacobson J. L., Rogan W. J. Polychlorinated biphenyls and the developing nervous system: cross-species comparisons. Neurotoxicol Teratol. 1990 May-Jun;12(3):239–248. doi: 10.1016/0892-0362(90)90095-t. [DOI] [PubMed] [Google Scholar]
  36. Walkowiak J., Wiener J. A., Fastabend A., Heinzow B., Krämer U., Schmidt E., Steingrüber H. J., Wundram S., Winneke G. Environmental exposure to polychlorinated biphenyls and quality of the home environment: effects on psychodevelopment in early childhood. Lancet. 2001 Nov 10;358(9293):1602–1607. doi: 10.1016/S0140-6736(01)06654-5. [DOI] [PubMed] [Google Scholar]

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