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. 2003 Apr;111(4):576–578. doi: 10.1289/ehp.5842

Hair analysis: exploring the state of the science.

Deanna K Harkins 1, Allan S Susten 1
PMCID: PMC1241447  PMID: 12676618

Abstract

On 12-13 June 2001, the Agency for Toxic Substances and Disease Registry (ATSDR) convened a seven-member panel in Atlanta, Georgia, to review and discuss the current state of the science related to hair analysis, specifically its use in assessing environmental exposures in support of the agency's public health assessment activities. ATSDR invited scientific experts in the fields of hair analysis, toxicology, and medicine to participate in a discussion of such topics as analytical methods, factors affecting the interpretation of analytical results, toxicologic considerations, and data gaps and research needs. The goal of the panel was to determine the overall utility of hair analysis as a tool to evaluate exposure at hazardous waste sites. The principal lesson learned from the meeting was that, for most substances, data are insufficient to predict health effects from the concentration of the substance in hair. The presence of a substance in hair may indicate exposure (both internal and external) but does not necessarily indicate the source of exposure. Thus, before hair analysis can be considered a valid tool for assessing exposure and health impact of a particular substance, research is needed to establish standardized reference ranges, gain a better understanding of biologic variations of hair growth with age, gender, race and ethnicity, and pharmacokinetics, and further explore possible dose-response relationships. ATSDR intends to use the findings of this panel to develop educational materials to support its site work and to encourage researchers to continue to develop methods that may facilitate reliable exposure assessments.

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Selected References

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  1. Barrett S. Commercial hair analysis. Science or scam? JAMA. 1985 Aug 23;254(8):1041–1045. [PubMed] [Google Scholar]
  2. Bencko V. Use of human hair as a biomarker in the assessment of exposure to pollutants in occupational and environmental settings. Toxicology. 1995 Jul 26;101(1-2):29–39. doi: 10.1016/0300-483x(95)03018-b. [DOI] [PubMed] [Google Scholar]
  3. Esteban E., Rubin C. H., Jones R. L., Noonan G. Hair and blood as substrates for screening children for lead poisoning. Arch Environ Health. 1999 Nov-Dec;54(6):436–440. doi: 10.1080/00039899909603376. [DOI] [PubMed] [Google Scholar]
  4. Fletcher D. J. Hair analysis. Proven and problematic applications. Postgrad Med. 1982 Nov;72(5):79-81, 84, 87-8. doi: 10.1080/00325481.1982.11716248. [DOI] [PubMed] [Google Scholar]
  5. Foo S. C., Khoo N. Y., Heng A., Chua L. H., Chia S. E., Ong C. N., Ngim C. H., Jeyaratnam J. Metals in hair as biological indices for exposure. Int Arch Occup Environ Health. 1993;65(1 Suppl):S83–S86. doi: 10.1007/BF00381312. [DOI] [PubMed] [Google Scholar]
  6. Frisch Melissa, Schwartz Brian S. The pitfalls of hair analysis for toxicants in clinical practice: three case reports. Environ Health Perspect. 2002 Apr;110(4):433–436. doi: 10.1289/ehp.02110433. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Hammer D. I., Finklea J. F., Hendricks R. H., Shy C. M., Horton R. J. Hair trace metal levels and environmental exposure. Am J Epidemiol. 1971 Feb;93(2):84–92. doi: 10.1093/oxfordjournals.aje.a121238. [DOI] [PubMed] [Google Scholar]
  8. Harkey M. R. Anatomy and physiology of hair. Forensic Sci Int. 1993 Dec;63(1-3):9–18. doi: 10.1016/0379-0738(93)90255-9. [DOI] [PubMed] [Google Scholar]
  9. Hindmarsh J. Thomas. Caveats in hair analysis in chronic arsenic poisoning. Clin Biochem. 2002 Feb;35(1):1–11. doi: 10.1016/s0009-9120(01)00282-x. [DOI] [PubMed] [Google Scholar]
  10. Hopps H. C. The biologic bases for using hair and nail for analyses of trace elements. Sci Total Environ. 1977 Jan;7(1):71–89. doi: 10.1016/0048-9697(77)90018-3. [DOI] [PubMed] [Google Scholar]
  11. Manson P., Zlotkin S. Hair analysis--a critical review. Can Med Assoc J. 1985 Aug 1;133(3):186–188. [PMC free article] [PubMed] [Google Scholar]
  12. Miekeley N., Dias Carneiro M. T., da Silveira C. L. How reliable are human hair reference intervals for trace elements? Sci Total Environ. 1998 Jul 11;218(1):9–17. doi: 10.1016/s0048-9697(98)00185-5. [DOI] [PubMed] [Google Scholar]
  13. Seidel S., Kreutzer R., Smith D., McNeel S., Gilliss D. Assessment of commercial laboratories performing hair mineral analysis. JAMA. 2001 Jan 3;285(1):67–72. doi: 10.1001/jama.285.1.67. [DOI] [PubMed] [Google Scholar]
  14. Sky-Peck H. H. Distribution of trace elements in human hair. Clin Physiol Biochem. 1990;8(2):70–80. [PubMed] [Google Scholar]
  15. Steindel S. J., Howanitz P. J. The uncertainty of hair analysis for trace metals. JAMA. 2001 Jan 3;285(1):83–85. doi: 10.1001/jama.285.1.83. [DOI] [PubMed] [Google Scholar]
  16. Taylor A. Usefulness of measurements of trace elements in hair. Ann Clin Biochem. 1986 Jul;23(Pt 4):364–378. doi: 10.1177/000456328602300402. [DOI] [PubMed] [Google Scholar]
  17. Valente D., Cassini M., Pigliapochi M., Vansetti G. Hair as the sample in assessing morphine and cocaine addiction. Clin Chem. 1981 Nov;27(11):1952–1953. [PubMed] [Google Scholar]
  18. Wennig R. Potential problems with the interpretation of hair analysis results. Forensic Sci Int. 2000 Jan 10;107(1-3):5–12. doi: 10.1016/s0379-0738(99)00146-2. [DOI] [PubMed] [Google Scholar]
  19. Yoshinaga J., Imai H., Nakazawa M., Suzuki T., Morita M. Lack of significantly positive correlations between elemental concentrations in hair and in organs. Sci Total Environ. 1990 Dec 1;99(1-2):125–135. doi: 10.1016/0048-9697(90)90217-i. [DOI] [PubMed] [Google Scholar]

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