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. 2003 Jul;111(9):1175–1179. doi: 10.1289/ehp.6220

High body burdens of 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) in California women.

Myrto Petreas 1, Jianwen She 1, F Reber Brown 1, Jennifer Winkler 1, Gayle Windham 1, Evan Rogers 1, Guomao Zhao 1, Rajiv Bhatia 1, M Judith Charles 1
PMCID: PMC1241571  PMID: 12842770

Abstract

Following our first report on elevated polybrominated diphenyl ether (PBDE) concentrations in California women, we expanded our investigation to include diverse groups of local women. We analyzed additional adipose and serum samples collected in the late 1990s from San Francisco Bay Area women participating in a breast cancer study and in a reproductive study, respectively. Adipose samples (n = 32) were analyzed by low-resolution mass spectrometry in negative-ion chemical ionization mode, whereas serum samples (n = 50) were analyzed by dual-column gas chromatography with electron capture detection. The results confirmed our earlier findings. Concentrations of 2,2,4,4 -tetrabromodiphenyl ether (BDE-47) in contemporary California women ranged between 5 and 510 ng/g lipid, with a median (16.5 ng/g lipid) 3-10 times higher than those reported from Europe. In contrast, PBDEs were not measurable in any of 420 archived serum samples collected in the 1960s from San Francisco Bay Area women participating in a study of child development. BDE-47 concentrations did not increase with age or with concentrations of a polychlorinated biphenyl (PCB-153), suggesting other routes of exposure in addition to diet. Rising body burdens of endocrine-disrupting chemicals such as PBDEs may pose a potential public health threat.

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Selected References

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  1. Archibeque-Engle S. L., Tessari J. D., Winn D. T., Keefe T. J., Nett T. M., Zheng T. Comparison of organochlorine pesticide and polychlorinated biphenyl residues in human breast adipose tissue and serum. J Toxicol Environ Health. 1997 Nov;52(4):285–293. doi: 10.1080/00984109708984065. [DOI] [PubMed] [Google Scholar]
  2. Darnerud P. O., Eriksen G. S., Jóhannesson T., Larsen P. B., Viluksela M. Polybrominated diphenyl ethers: occurrence, dietary exposure, and toxicology. Environ Health Perspect. 2001 Mar;109 (Suppl 1):49–68. doi: 10.1289/ehp.01109s149. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Eriksson P., Jakobsson E., Fredriksson A. Brominated flame retardants: a novel class of developmental neurotoxicants in our environment? Environ Health Perspect. 2001 Sep;109(9):903–908. doi: 10.1289/ehp.01109903. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Hooper K., McDonald T. A. The PBDEs: an emerging environmental challenge and another reason for breast-milk monitoring programs. Environ Health Perspect. 2000 May;108(5):387–392. doi: 10.1289/ehp.00108387. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. James Rebecca A., Hertz-Picciotto Irva, Willman Eric, Keller Jean A., Charles M. Judith. Determinants of serum polychlorinated biphenyls and organochlorine pesticides measured in women from the child health and development study cohort, 1963-1967. Environ Health Perspect. 2002 Jul;110(7):617–624. doi: 10.1289/ehp.02110617. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. López-Carrillo L., Torres-Sánchez L., López-Cervantes M., Blair A., Cebrián M. E., Uribe M. The adipose tissue to serum dichlorodiphenyldichloroethane (DDE) ratio: some methodological considerations. Environ Res. 1999 Aug;81(2):142–145. doi: 10.1006/enrs.1999.3961. [DOI] [PubMed] [Google Scholar]
  7. McDonald Thomas A. A perspective on the potential health risks of PBDEs. Chemosphere. 2002 Feb;46(5):745–755. doi: 10.1016/s0045-6535(01)00239-9. [DOI] [PubMed] [Google Scholar]
  8. Mills Graham, Yardley Anne-Marie, Thomas Mark, Blackmore Tim, Pithie Alan, Schroeder Bryan, Dickson Nigel. New Zealand's HIV infected population under active follow-up during 2000. N Z Med J. 2002 Apr 26;115(1152):173–176. [PubMed] [Google Scholar]
  9. Mussalo-Rauhamaa H. Partitioning and levels of neutral organochlorine compounds in human serum, blood cells, and adipose and liver tissue. Sci Total Environ. 1991 Apr 15;103(2-3):159–175. doi: 10.1016/0048-9697(91)90142-2. [DOI] [PubMed] [Google Scholar]
  10. Ohta Souichi, Ishizuka Daisuke, Nishimura Hajime, Nakao Teruyuki, Aozasa Osamu, Shimidzu Yoshiko, Ochiai Fumie, Kida Takafumi, Nishi Masatoshi, Miyata Hideaki. Comparison of polybrominated diphenyl ethers in fish, vegetables, and meats and levels in human milk of nursing women in Japan. Chemosphere. 2002 Feb;46(5):689–696. doi: 10.1016/s0045-6535(01)00233-8. [DOI] [PubMed] [Google Scholar]
  11. Phillips D. L., Pirkle J. L., Burse V. W., Bernert J. T., Jr, Henderson L. O., Needham L. L. Chlorinated hydrocarbon levels in human serum: effects of fasting and feeding. Arch Environ Contam Toxicol. 1989 Jul-Aug;18(4):495–500. doi: 10.1007/BF01055015. [DOI] [PubMed] [Google Scholar]
  12. She Jianwen, Petreas Myrto, Winkler Jennifer, Visita Patria, McKinney Michael, Kopec Dianne. PBDEs in the San Francisco Bay Area: measurements in harbor seal blubber and human breast adipose tissue. Chemosphere. 2002 Feb;46(5):697–707. doi: 10.1016/s0045-6535(01)00234-x. [DOI] [PubMed] [Google Scholar]
  13. Sjödin A., Patterson D. G., Jr, Bergman A. Brominated flame retardants in serum from U.S. blood donors. Environ Sci Technol. 2001 Oct 1;35(19):3830–3833. doi: 10.1021/es010815n. [DOI] [PubMed] [Google Scholar]
  14. Smith D. Worldwide trends in DDT levels in human breast milk. Int J Epidemiol. 1999 Apr;28(2):179–188. doi: 10.1093/ije/28.2.179. [DOI] [PubMed] [Google Scholar]
  15. Thomsen Cathrine, Lundanes Elsa, Becher Georg. Brominated flame retardants in archived serum samples from Norway: a study on temporal trends and the role of age. Environ Sci Technol. 2002 Apr 1;36(7):1414–1418. doi: 10.1021/es0102282. [DOI] [PubMed] [Google Scholar]
  16. de Boer J., Wester P. G., Klamer H. J., Lewis W. E., Boon J. P. Do flame retardants threaten ocean life? Nature. 1998 Jul 2;394(6688):28–29. doi: 10.1038/27798. [DOI] [PubMed] [Google Scholar]
  17. de Wit Cynthia A. An overview of brominated flame retardants in the environment. Chemosphere. 2002 Feb;46(5):583–624. doi: 10.1016/s0045-6535(01)00225-9. [DOI] [PubMed] [Google Scholar]
  18. van den Berg B. J. The California Child Health and Development Studies: twenty years of research. World Health Stat Q. 1979;32(4):269–286. [PubMed] [Google Scholar]

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