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. 1981;319:543–554. doi: 10.1113/jphysiol.1981.sp013925

Effects from fine muscle and cutaneous afferents on spinal locomotion in cats

K-D Kniffki *, E D Schomburg *, H Steffens *
PMCID: PMC1243855  PMID: 7320927

Abstract

1. The effects of chemically activated fine muscle afferents (groups III and IV) and electrically activated cutaneous afferents on motoneuronal discharges were studied before and during fictive locomotion induced pharmacologically by i.v. administration of nialamide and l-DOPA in high spinal cats. Efferent activity was recorded simultaneously from nerve filaments to ipsi- and contralateral extensor and flexor muscles. In addition, intracellular recordings were made from lumbar α-motoneurones.

2. After nialamide but before treatment with l-DOPA, in some cases, transient locomotor-like discharges were induced by an increased activity in fine muscle afferents. The response pattern in nerves to both hind limbs could be different showing e.g. only transient alternating activity between knee flexor and extensor of one limb but not of the other one.

3. Treatment with l-DOPA did not always cause fictive locomotion. Often not all motoneurone pools showed rhythmic activity. In these cases stimulation of group III and IV muscle afferents usually caused transient periodic activity. In cases with apparent rhythmic activity, algesic stimulation of the gastrocnemius—soleus muscle caused an accentuation of the rhythm by a more abrupt transition from the active phase to the non-active interval. Again, the response patterns on both sides were not uniform in all cases.

4. A second type of response to activation of fine muscle afferents had a quite different character: the rhythmic activity was more or less completely overridden by a strong transient tonic hyperactivity or the rhythm was transiently blocked. These phenomena did not occur in the same way in all nerves.

5. Electrical stimulation of cutaneous nerves of the hind limb generally induced the same response pattern as chemical stimulation of the group III and IV muscle afferents. The effects varied depending on the stimulus strength and the nerve.

6. The results revealed that cutaneous and fine muscle afferents not only have similar functions in the reflex control of a limb but also in evocation and modulation of locomotion. Therefore, it is assumed that both types of afferents may serve together as a peripheral feed-back to the spinal locomotor centre.

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Selected References

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  1. Andersson O., Forssberg H., Grillner S., Lindquist M. Phasic gain control of the transmission in cutaneous reflex pathways to motoneurones during 'fictive' locomotion. Brain Res. 1978 Jun 30;149(2):503–507. doi: 10.1016/0006-8993(78)90493-6. [DOI] [PubMed] [Google Scholar]
  2. Andersson O., Grillner S., Lindquist M., Zomlefer M. Peripheral control of the spinal pattern generators for locomotion in cat. Brain Res. 1978 Jul 21;150(3):625–630. doi: 10.1016/0006-8993(78)90827-2. [DOI] [PubMed] [Google Scholar]
  3. Coffman J. D. The effect of aspirin on pain and hand blood flow responses to intra-arterial injection of bradykinin in man. Clin Pharmacol Ther. 1966 Jan-Feb;7(1):26–37. doi: 10.1002/cpt19667126. [DOI] [PubMed] [Google Scholar]
  4. Egger M. D., Wyman R. J. A reappraisal of reflex stepping in the cat. J Physiol. 1969 Jun;202(2):501–516. doi: 10.1113/jphysiol.1969.sp008823. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Fock S., Mense S. Excitatory effects of 5-hydroxytryptamine, histamine and potassium ions on muscular group IV afferent units: a comparison with bradykinin. Brain Res. 1976 Apr 9;105(3):459–469. doi: 10.1016/0006-8993(76)90593-x. [DOI] [PubMed] [Google Scholar]
  6. Forssberg H., Grillner S., Rossignol S. Phase dependent reflex reversal during walking in chronic spinal cats. Brain Res. 1975 Feb 21;85(1):103–107. doi: 10.1016/0006-8993(75)91013-6. [DOI] [PubMed] [Google Scholar]
  7. Forssberg H., Grillner S., Rossignol S. Phasic gain control of reflexes from the dorsum of the paw during spinal locomotion. Brain Res. 1977 Aug 19;132(1):121–139. doi: 10.1016/0006-8993(77)90710-7. [DOI] [PubMed] [Google Scholar]
  8. Forssberg H. Stumbling corrective reaction: a phase-dependent compensatory reaction during locomotion. J Neurophysiol. 1979 Jul;42(4):936–953. doi: 10.1152/jn.1979.42.4.936. [DOI] [PubMed] [Google Scholar]
  9. Franz M., Mense S. Muscle receptors with group IV afferent fibres responding to application of bradykinin. Brain Res. 1975 Jul 18;92(3):369–383. doi: 10.1016/0006-8993(75)90323-6. [DOI] [PubMed] [Google Scholar]
  10. GUZMAN F., BRAUN C., LIM R. K. Visceral pain and the pseudaffective response to intra-arterial injection of bradykinin and other algesic agents. Arch Int Pharmacodyn Ther. 1962 Apr 1;136:353–384. [PubMed] [Google Scholar]
  11. Grillner S. Locomotion in vertebrates: central mechanisms and reflex interaction. Physiol Rev. 1975 Apr;55(2):247–304. doi: 10.1152/physrev.1975.55.2.247. [DOI] [PubMed] [Google Scholar]
  12. Grillner S., Zangger P. On the central generation of locomotion in the low spinal cat. Exp Brain Res. 1979 Jan 15;34(2):241–261. doi: 10.1007/BF00235671. [DOI] [PubMed] [Google Scholar]
  13. Hong S. K., Kniffke K. D., Mense S., Schmidt R. F., Wendisch M. Descending influences on the responses of spinocervical tract neurones to chemical stimulation of fine muscle afferents. J Physiol. 1979 May;290(2):129–140. doi: 10.1113/jphysiol.1979.sp012764. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Jankowska E., Jukes M. G., Lund S., Lundberg A. The effect of DOPA on the spinal cord. 6. Half-centre organization of interneurones transmitting effects from the flexor reflex afferents. Acta Physiol Scand. 1967 Jul-Aug;70(3):389–402. doi: 10.1111/j.1748-1716.1967.tb03637.x. [DOI] [PubMed] [Google Scholar]
  15. Kniffki K. D., Mense S., Schmidt R. F. Responses of group IV afferent units from skeletal muscle to stretch, contraction and chemical stimulation. Exp Brain Res. 1978 Apr 14;31(4):511–522. doi: 10.1007/BF00239809. [DOI] [PubMed] [Google Scholar]
  16. Kniffki K. D., Schomburg E. D., Steffens H. Action of muscular group III and IV afferents on spinal locomotor activity in cat. Brain Res. 1980 Mar 31;186(2):445–447. doi: 10.1016/0006-8993(80)90988-9. [DOI] [PubMed] [Google Scholar]
  17. Kniffki K. D., Schomburg E. D., Steffens H. Synaptic effects from chemically activated fine muscle afferents upon alpha-motoneurones in decerebrate and spinal cats. Brain Res. 1981 Feb 16;206(2):361–370. doi: 10.1016/0006-8993(81)90537-0. [DOI] [PubMed] [Google Scholar]
  18. Kniffki K. D., Schomburg E. D., Steffens H. Synaptic responses of lumbar alpha-motoneurones to chemical algesic stimulation of skeletal muscle in spinal cats. Brain Res. 1979 Jan 19;160(3):549–552. doi: 10.1016/0006-8993(79)91085-0. [DOI] [PubMed] [Google Scholar]
  19. Lundberg A. Multisensory control of spinal reflex pathways. Prog Brain Res. 1979;50:11–28. doi: 10.1016/S0079-6123(08)60803-1. [DOI] [PubMed] [Google Scholar]
  20. Mense S. Nervous outflow from skeletal muscle following chemical noxious stimulation. J Physiol. 1977 May;267(1):75–88. doi: 10.1113/jphysiol.1977.sp011802. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Schomburg E. D., Behrends H. B. The possibility of phase-dependent monosynaptic and polysynaptic is excitation to homonymous motoneurones during fictive locomotion. Brain Res. 1978 Mar 31;143(3):533–537. doi: 10.1016/0006-8993(78)90363-3. [DOI] [PubMed] [Google Scholar]
  22. Schomburg E. D., Meinck H. M., Haustein J., Roesler J. Functional organization of the spinal reflex pathways from forelimb afferents to hindlimb motoneurones in the cat. Brain Res. 1978 Jan 6;139(1):21–33. doi: 10.1016/0006-8993(78)90057-4. [DOI] [PubMed] [Google Scholar]
  23. Shik M. L., Orlovsky G. N. Neurophysiology of locomotor automatism. Physiol Rev. 1976 Jul;56(3):465–501. doi: 10.1152/physrev.1976.56.3.465. [DOI] [PubMed] [Google Scholar]
  24. Viala D., Buser P. Modalitś d'obtention de rythmes locomoteurs chez le lapin spinal par traitements pharmacologiques (DOPA, 5-HTP, D-amphétamine. Brain Res. 1971 Dec 10;35(1):151–165. doi: 10.1016/0006-8993(71)90601-9. [DOI] [PubMed] [Google Scholar]
  25. Viala G., Orsal D., Buser P. Cutaneous fiber groups involved in the inhibition of fictive locomotion in the rabbit. Exp Brain Res. 1978 Oct 13;33(2):257–267. doi: 10.1007/BF00238064. [DOI] [PubMed] [Google Scholar]

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