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. 1981 Jun;315:31–41. doi: 10.1113/jphysiol.1981.sp013730

Pancreatic endocrine responses to stimulation of the peripheral ends of the vagus nerves in conscious calves.

S R Bloom, A V Edwards
PMCID: PMC1249365  PMID: 7031230

Abstract

1. The effects of stimulation of the peripheral ends of both vagus nerves below the heart (10 Hz for 10 min) were investigated in conscious calves 2-5 weeks after birth. 2. Stimulation was invariably below behavioural threshold and caused a prompt increase in the concentrations of pancreatic glucagon, insulin and pancreatic polypeptide (PP) in the arterial plasma. Each of these responses was blocked by pretreatment with atropine (0.2 mg/kg). 3. Administration of exogenous glucose by continuous I.V. infusion (ca. 0.08 mmol kg-1 min-1) greatly enhanced the release of insulin in response to vagal stimulation without significantly changing that of pancreatic glucagon or PP. 4. Vagal stimulation also caused a significant rise in the concentration of vasoactive intestinal peptide (VIP) in the intestinal lymph and this response was found to persist in the presence of atropine.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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