Abstract
1. The release of catecholamines from the adrenal medulla, in response to carotid body hypoxia, may outlast the stimulus by more than 30 min. 2. After denervation of the adrenal gland the immediate release of catecholamines in response to carotid hypoxia is abolished, but the prolonged release remains. 3. The prolonged release of catecholamines is abolished by cycloheximide. 4. Both corticotrophin in vivo and hydrocortisone in the isolated perfused adrenal gland release adrenomedullary catecholamines. 5. It is concluded that a component of the response of the adrenal medulla to carotid body hypoxia is mediated by corticotrophin and corticosteroid release.
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Selected References
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- ANICHKOV S. V., MALYGHINA E. I., POSKALENKO A. N., RYZHENKOV V. E. Reflexes from carotid bodies upon the adrenals. Arch Int Pharmacodyn Ther. 1960 Dec 1;129:156–165. [PubMed] [Google Scholar]
- Critchley J. A., Ellis P., Ungar A. The reflex release of adrenaline and noradrenaline from the adrenal glands of cats and dogs. J Physiol. 1980 Jan;298:71–78. doi: 10.1113/jphysiol.1980.sp013067. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Critchley J. A., Ungar A., Welburn P. J. Proceedings: The release of adrenaline and noradrenaline by the adrenal glands of cats and dogs in reflexes arising from the carotid chemoreceptors and baroreceptors. J Physiol. 1973 Oct;234(2):111P–112P. [PubMed] [Google Scholar]
- Garren L. D., Ney R. L., Davis W. W. Studies on the role of protein synthesis in the regulation of corticosterone production by adrenocorticotropic hormone in vivo. Proc Natl Acad Sci U S A. 1965 Jun;53(6):1443–1450. doi: 10.1073/pnas.53.6.1443. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Henderson C. G., Ungar A. Effect of cholinergic antagonists on sympathetic ganglionic transmission of vasomotor reflexes from the carotid baroreceptors and chemoreceptors of the dog. J Physiol. 1978 Apr;277:379–385. doi: 10.1113/jphysiol.1978.sp012278. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Marotta S. F. Comparative effects of hypoxia, adrenocorticotropin and methylcholine on adrenocortical secretory rates. Proc Soc Exp Biol Med. 1972 Dec;141(3):923–927. doi: 10.3181/00379727-141-36902. [DOI] [PubMed] [Google Scholar]
- Wurtman R. J., Casper A., Pohorecky L. A., Bartter F. C. Impaired secretion of epinephrine in response to insulin among hypophysectomized dogs. Proc Natl Acad Sci U S A. 1968 Oct;61(2):522–528. doi: 10.1073/pnas.61.2.522. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wurtman R. J., Pohorecky L. A., Baliga B. S. Adrenocortical control of the biosynthesis of epinephrine and proteins in the adrenal medulla. Pharmacol Rev. 1972 Jun;24(2):411–426. [PubMed] [Google Scholar]