Skip to main content
PMC home page
Annals of Surgery logoLink to Annals of Surgery
. 1986 Jul;204(1):53–58. doi: 10.1097/00000658-198607000-00007

Effect of analgesic drugs on the electromyographic activity of the gastrointestinal tract and sphincter of Oddi and on biliary pressure.

J C Coelho, N Senninger, N Runkel, C Herfarth, K Messmer
PMCID: PMC1251222  PMID: 3729583

Abstract

Continuous biliary pressure and electromyographic activity of the sphincter of Oddi and gastrointestinal tract were recorded in conscious opossums following administration of analgesic drugs. Morphine, meperidine, and pentazocin increased significantly the duration of the migrating motor complex (MMC) cycle. Periods of 1-2 minutes of intense burst of spike potentials were seen in the sphincter of Oddi and duodenum following administration of morphine (8 experiments), meperidine (6 experiments), and pentazocin (3 experiments). The biliary pressure in the control studies was similar to that following administration of all analgesics in the animals with gallbladder and following instillation of tramadol, metamizol, and acetylsalicylic acid in animals with no gallbladder. However, the biliary pressure was significantly higher following administration of morphine, meperidine, and pentazocin in the animals with no gallbladder. It is concluded from this study that morphine, meperidine, and pentazocin may cause important disturbances in the motility of the sphincter of Oddi and gastrointestinal tract. These myoelectric disturbances may cause an increase in the biliary pressure in animals that have been subjected to cholecystectomy, but not in animals with intact gallbladder. The gallbladder may accommodate the bile produced by the liver during periods of sphincter of Oddi dysfunction and thus impede an increase in the biliary pressure.

Full text

PDF
55

Images in this article

55FIG. 1.
on p.55
56FIG. 2.
on p.56
57FIGS. 3A and B.
on p.57

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Arguelles J. E., Franatovic Y., Romo-Salas F., Aldrete J. A. Intrabiliary pressure changes produced by narcotic drugs and inhalation anesthetics in guinea pigs. Anesth Analg. 1979 Mar-Apr;58(2):120–123. [PubMed] [Google Scholar]
  2. BASS P., WILEY J. N. EFFECTS OF LIGATION AND MORPHINE ON ELECTRIC AND MOTOR ACTIVITY OF DOG DUODENUM. Am J Physiol. 1965 May;208:908–913. doi: 10.1152/ajplegacy.1965.208.5.908. [DOI] [PubMed] [Google Scholar]
  3. Becker J. M., Moody F. G., Zinsmeister A. R. Effect of gastrointestinal hormones on the biliary sphincter of the opossum. Gastroenterology. 1982 Jun;82(6):1300–1307. [PubMed] [Google Scholar]
  4. CHAPMAN W. P., ROWLANDS E. N., JONES C. M. Multiple-balloon kymographic recording of the comparative action of demerol, morphine and placebos on the motility of the upper small intestine in man. N Engl J Med. 1950 Aug 3;243(5):171–177. doi: 10.1056/NEJM195008032430501. [DOI] [PubMed] [Google Scholar]
  5. Chessick K. C., Black S., Hoye S. J. Spasm and operative cholangiography. Arch Surg. 1975 Jan;110(1):53–57. doi: 10.1001/archsurg.1975.01360070053009. [DOI] [PubMed] [Google Scholar]
  6. Code C. F., Marlett J. A. The interdigestive myo-electric complex of the stomach and small bowel of dogs. J Physiol. 1975 Mar;246(2):289–309. doi: 10.1113/jphysiol.1975.sp010891. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Coelho J. C., Moody F. G., Senninger N. A new method for correlating pancreatic and biliary duct pressures and sphincter of Oddi electromyography. Surgery. 1985 Mar;97(3):342–349. [PubMed] [Google Scholar]
  8. DANIEL E. E., SUTHERLAND W. H., BOGOCH A. Effects of morphine and other drugs on motility of the terminal ileum. Gastroenterology. 1959 Apr;36(4):510–523. [PubMed] [Google Scholar]
  9. Economou G., Ward-McQuaid J. N. A cross-over comparison of the effect of morphine, pethidine, pentazocine, and phenazocine on biliary pressure. Gut. 1971 Mar;12(3):218–221. doi: 10.1136/gut.12.3.218. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Greenstein A. J., Kaynan A., Singer A., Dreiling D. A. A comparative study of pentazocine and meperidine on the biliary passage pressure. Am J Gastroenterol. 1972 Oct;58(4):417–427. [PubMed] [Google Scholar]
  11. Honda R., Toouli J., Dodds W. J., Sarna S., Hogan W. J., Itoh Z. Relationship of sphincter of Oddi spike bursts to gastrointestinal myoelectric activity in conscious opossums. J Clin Invest. 1982 Apr;69(4):770–778. doi: 10.1172/JCI110515. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Joehl R. J., Koch K. L., Nahrwold D. L. Opioid drugs cause bile duct obstruction during hepatobiliary scans. Am J Surg. 1984 Jan;147(1):134–138. doi: 10.1016/0002-9610(84)90047-3. [DOI] [PubMed] [Google Scholar]
  13. Jones R. M., Fiddian-Green R., Knight P. R. Narcotic-induced choledochoduodenal sphincter spasm reversed by glucagon. Anesth Analg. 1980 Dec;59(12):946–947. [PubMed] [Google Scholar]
  14. McCammon R. L., Viegas O. J., Stoelting R. K., Dryden G. E. Naloxone reversal of choledochoduodenal sphincter spasm associated with narcotic administration. Anesthesiology. 1978 Jun;48(6):437–437. doi: 10.1097/00000542-197806000-00011. [DOI] [PubMed] [Google Scholar]
  15. Persson C. G., Ekman M. Effect of morphine, cholecystokinin and sympathomimetics on the sphincter of Oddi and intramural pressure in cat duodenum. Scand J Gastroenterol. 1972;7(4):345–351. doi: 10.3109/00365527209180753. [DOI] [PubMed] [Google Scholar]
  16. Romo-Salas F., Aldrete J. A., Franatovic Y. Effects of butorphanol, fentanyl and morphine on the intrabiliary pressure of guinea pigs. Surg Gynecol Obstet. 1980 Apr;150(4):551–554. [PubMed] [Google Scholar]
  17. Sarna S., Northcott P., Belbeck L. Mechanism of cycling of migrating myoelectric complexes: effect of morphine. Am J Physiol. 1982 Jun;242(6):G588–G595. doi: 10.1152/ajpgi.1982.242.6.G588. [DOI] [PubMed] [Google Scholar]
  18. Stewart J. J., Weisbrodt N. W., Burks T. F. Central and peripheral actions of morphine on intestinal transit. J Pharmacol Exp Ther. 1978 Jun;205(3):547–555. [PubMed] [Google Scholar]

Articles from Annals of Surgery are provided here courtesy of Lippincott, Williams, and Wilkins

RESOURCES