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. 1986 Dec;204(6):681–685. doi: 10.1097/00000658-198612000-00011

Effect of blood transfusions on macrophage-lymphocyte interaction in an animal model.

J P Waymack, K Balakrishnan, N McNeal, S Gonce, P Miskell, G D Warden, J W Alexander
PMCID: PMC1251425  PMID: 3491587

Abstract

Blood transfusions have been reported over the last 2 decades to decrease allograft rejection, to increase the rate of tumor growth, and to increase susceptibility to infectious complications. The effect of transfusions on macrophages, specifically on their regulation of lymphocyte proliferation, was investigated. Both macrophages and their supernatants obtained from transfused rats impaired lymphocyte blastogenesis to a greater degree than those from nontransfused rats. This effect was greatest when the lymphocytes were subjected to mitogen stimulation. The immunosuppression was seen with macrophages from both allogeneically and syngeneically transfused rats. Blood transfusions exert their immunosuppressive effect at least in part by increasing macrophage suppression of lymphocyte response to stimuli.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Burrows L., Tartter P. Effect of blood transfusions on colonic malignancy recurrent rate. Lancet. 1982 Sep 18;2(8299):662–662. doi: 10.1016/s0140-6736(82)92764-7. [DOI] [PubMed] [Google Scholar]
  2. Dinarello C. A. Interleukin-1. Rev Infect Dis. 1984 Jan-Feb;6(1):51–95. doi: 10.1093/clinids/6.1.51. [DOI] [PubMed] [Google Scholar]
  3. Fabre J. W., Morris P. J. The effect of donor strain blood pretreatment on renal allograft rejection in rats. Transplantation. 1972 Nov;14(5):608–617. doi: 10.1097/00007890-197211000-00013. [DOI] [PubMed] [Google Scholar]
  4. Foster R. S., Jr, Costanza M. C., Foster J. C., Wanner M. C., Foster C. B. Adverse relationship between blood transfusions and survival after colectomy for colon cancer. Cancer. 1985 Mar 15;55(6):1195–1201. doi: 10.1002/1097-0142(19850315)55:6<1195::aid-cncr2820550610>3.0.co;2-h. [DOI] [PubMed] [Google Scholar]
  5. Foster R. S., Jr, Foster J. C., Costanza M. C. Blood transfusions and survival after surgery for breast cancer. Arch Surg. 1984 Oct;119(10):1138–1140. doi: 10.1001/archsurg.1984.01390220024005. [DOI] [PubMed] [Google Scholar]
  6. Goodwin J. S., Webb D. R. Regulation of the immune response by prostaglandins. Clin Immunol Immunopathol. 1980 Jan;15(1):106–122. doi: 10.1016/0090-1229(80)90024-0. [DOI] [PubMed] [Google Scholar]
  7. HALASZ N. A., ORLOFF M. J., HIROSE F. INCREASED SURVIVAL OF RENAL HOMOGRAFTS IN DOGS AFTER INJECTION OF GRAFT DONOR BLOOD. Transplantation. 1964 Jul;2:453–458. doi: 10.1097/00007890-196407000-00001. [DOI] [PubMed] [Google Scholar]
  8. Hyman N. H., Foster R. S., Jr, DeMeules J. E., Costanza M. C. Blood transfusions and survival after lung cancer resection. Am J Surg. 1985 Apr;149(4):502–507. doi: 10.1016/s0002-9610(85)80047-7. [DOI] [PubMed] [Google Scholar]
  9. Jenkins A. M., Woodruff M. F. The effect of prior administration of donor strain blood or blood constituents on the survival of cardiac allografts in rats. Transplantation. 1971 Jul;12(1):57–60. doi: 10.1097/00007890-197107000-00010. [DOI] [PubMed] [Google Scholar]
  10. Kaplan J., Sarnaik S., Gitlin J., Lusher J. Diminished helper/suppressor lymphocyte ratios and natural killer activity in recipients of repeated blood transfusions. Blood. 1984 Jul;64(1):308–310. [PubMed] [Google Scholar]
  11. Kessler C. M., Schulof R. S., Goldstein A. L., Naylor P. H., Luban N. L., Kelleher J. F., Reaman G. H. Abnormal T-lymphocyte subpopulations associated with transfusion of blood-derived products. Lancet. 1983 Apr 30;1(8331):991–992. doi: 10.1016/s0140-6736(83)92116-5. [DOI] [PubMed] [Google Scholar]
  12. Nathanson S. D., Tilley B. C., Schultz L., Smith R. F. Perioperative allogeneic blood transfusions. Survival in patients with resected carcinomas of the colon and rectum. Arch Surg. 1985 Jun;120(6):734–738. doi: 10.1001/archsurg.1985.01390300076013. [DOI] [PubMed] [Google Scholar]
  13. Nowak M. M., Ponsky J. L. Blood transfusion and disease-free survival in carcinoma of the breast. J Surg Oncol. 1984 Oct;27(2):124–130. doi: 10.1002/jso.2930270214. [DOI] [PubMed] [Google Scholar]
  14. Opelz G., Sengar D. P., Mickey M. R., Terasaki P. I. Effect of blood transfusions on subsequent kidney transplants. Transplant Proc. 1973 Mar;5(1):253–259. [PubMed] [Google Scholar]
  15. Ota D., Alvarez L., Lichtiger B., Giacco G., Guinee V. Perioperative blood transfusion in patients with colon carcinoma. Transfusion. 1985 Jul-Aug;25(4):392–394. doi: 10.1046/j.1537-2995.1985.25485273825.x. [DOI] [PubMed] [Google Scholar]
  16. Rosenberg S. A., Seipp C. A., White D. E., Wesley R. Perioperative blood transfusions are associated with increased rates of recurrence and decreased survival in patients with high-grade soft-tissue sarcomas of the extremities. J Clin Oncol. 1985 May;3(5):698–709. doi: 10.1200/JCO.1985.3.5.698. [DOI] [PubMed] [Google Scholar]
  17. Tartter P. I., Burrows L., Kirschner P. Perioperative blood transfusion adversely affects prognosis after resection of Stage I (subset N0) non-oat cell lung cancer. J Thorac Cardiovasc Surg. 1984 Nov;88(5 Pt 1):659–662. [PubMed] [Google Scholar]
  18. Waymack J. P., Gallon L., Barcelli U., Alexander J. W. Effect of blood transfusions on macrophage function in a burned animal model. Curr Surg. 1986 Jul-Aug;43(4):305–307. [PubMed] [Google Scholar]
  19. Waymack J. P., Rapien J., Garnett D., Tweddell J. S., Alexander J. W. Effect of transfusion on immune function in a traumatized animal model. Arch Surg. 1986 Jan;121(1):50–55. doi: 10.1001/archsurg.1986.01400010056007. [DOI] [PubMed] [Google Scholar]

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