Skip to main content
PMC home page
Canadian Journal of Veterinary Research logoLink to Canadian Journal of Veterinary Research
. 1987 Jul;51(3):326–333.

Pathogenesis of ovine pseudorabies (Aujeszky's disease) following intratracheal inoculation.

S P Schmidt 1, W A Hagemoser 1, J P Kluge 1, H T Hill 1
PMCID: PMC1255332  PMID: 2820559

Abstract

Pseudorabies virus was inoculated intratracheally into sheep to investigate the pathogenesis of pseudorabies virus infection. Clinical signs of pyrexia, depression, frequent swallowing, facial fasciculations, chorea, excessive salivation, mild tympanites, labored breathing and focal pruritus were followed by death Macroscopic lesions were severe focal facial trauma, petechiae in cervicothoracic ganglia and dilated esophaguses. The medulla oblongata and the trigeminal, cranial cervical, cervicothoracic and parabronchial ganglia contained pseudorabies virus and pronounced nonsuppurative inflammatory changes. The neural distribution of lesions and virus suggests that the virus travelled from the respiratory mucosa to the central and sympathetic nervous system by two routes: 1) in the vagus and glossopharyngeal nerves to the medulla oblongata and 2) in the postganglionic fibers to the sympathetic ganglia. The presence of virus in the nasal mucus indicated that horizontal transmission of pseudorabies virus may occur among sheep.

Full text

PDF
332

Images in this article

329Fig. 2.
on p.329
329Fig. 3.
on p.329
330Fig. 4.
on p.330
330Fig. 5.
on p.330
331Fig. 6.
on p.331
331Fig. 7.
on p.331
332Fig. 8.
on p.332

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Becker C. H. Zur primären Schädigung vegetativer Ganglien nach Infektion mit dem Herpes suis Virus bei verschiedenen Tierarten. Experientia. 1967 Mar 15;23(3):209–210. doi: 10.1007/BF02136291. [DOI] [PubMed] [Google Scholar]
  2. DEMPSHER J., LARRABEE M. G., BANG F. B., BODIAN D. Physiological changes in sympathetic ganglia infected with pseudorabies virus. Am J Physiol. 1955 Jul;182(1):203–216. doi: 10.1152/ajplegacy.1955.182.1.203. [DOI] [PubMed] [Google Scholar]
  3. DOW C., MCFERRAN J. B. EXPERIMENTAL AUJESZKY'S DISEASE IN THE SHEEP. Am J Vet Res. 1964 Mar;25:461–468. [PubMed] [Google Scholar]
  4. Dolivo M., Beretta E., Bonifas V., Foroglou C. Ultrastructure and function in sympathetic ganglia isolated from rats infected with pseudorabies virus. Brain Res. 1978 Jan 20;140(1):111–123. doi: 10.1016/0006-8993(78)90241-x. [DOI] [PubMed] [Google Scholar]
  5. Donaldson A. I., Wardley R. C., Martin S., Ferris N. P. Experimental Aujeszky's disease in pigs: excretion, survival and transmission of the virus. Vet Rec. 1983 Nov 19;113(21):490–494. doi: 10.1136/vr.113.21.490. [DOI] [PubMed] [Google Scholar]
  6. Gloster J., Donaldson A. I., Hough M. N. Analysis of a series of outbreaks of Aujeszky's disease in Yorkshire in 1981-82: the possibility of airborne disease spread. Vet Rec. 1984 Mar 10;114(10):234–239. doi: 10.1136/vr.114.10.234. [DOI] [PubMed] [Google Scholar]
  7. Godinho H. P. The glossopharyngeal and vagus nerves in the retropharyngeal region of goat, sheep and cattle. Zentralbl Veterinarmed C. 1973 Jun;2(2):120–126. [PubMed] [Google Scholar]
  8. Kalia M., Mesulam M. M. Brain stem projections of sensory and motor components of the vagus complex in the cat: II. Laryngeal, tracheobronchial, pulmonary, cardiac, and gastrointestinal branches. J Comp Neurol. 1980 Sep 15;193(2):467–508. doi: 10.1002/cne.901930211. [DOI] [PubMed] [Google Scholar]
  9. Martin X., Dolivo M. Neuronal and transneuronal tracing in the trigeminal system of the rat using the herpes virus suis. Brain Res. 1983 Aug 29;273(2):253–276. doi: 10.1016/0006-8993(83)90850-8. [DOI] [PubMed] [Google Scholar]
  10. Matsushita M., Okado N., Ikeda M., Hosoya Y. Descending projections from the spinal and mesencephalic nuclei of the trigeminal nerve to the spinal cord in the cat. A study with the horseradish peroxidase technique. J Comp Neurol. 1981 Feb 20;196(2):173–187. doi: 10.1002/cne.901960202. [DOI] [PubMed] [Google Scholar]
  11. McCracken R. M., McFerran J. B., Dow C. The neural spread of pseudorabies virus in calves. J Gen Virol. 1973 Jul;20(1):17–28. doi: 10.1099/0022-1317-20-1-17. [DOI] [PubMed] [Google Scholar]
  12. Richardson J. B. Nerve supply to the lungs. Am Rev Respir Dis. 1979 May;119(5):785–802. doi: 10.1164/arrd.1979.119.5.785. [DOI] [PubMed] [Google Scholar]
  13. Schäfer M., Gudat E. Beitrag zum Auftreten von Aujeszkyscher Krankheit beim Schaf. Monatsh Veterinarmed. 1966 Mar 15;21(6):201–203. [PubMed] [Google Scholar]
  14. Senf W., Seffner W. Erfahrungen bei der Aujeszkyschen Krankheit unter besonderer Berücksichtigung einiger Fälle bei Schafen und Rindern. Monatsh Veterinarmed. 1966 Jan 15;21(2):58–64. [PubMed] [Google Scholar]
  15. Thawley D. G., Wright J. C., Solorzano R. F. Epidemiologic monitoring following an episode of pseudorabies involving swine, sheep, and cattle. J Am Vet Med Assoc. 1980 May 15;176(10 Pt 1):1001–1003. [PubMed] [Google Scholar]

Articles from Canadian Journal of Veterinary Research are provided here courtesy of Canadian Veterinary Medical Association

RESOURCES