Abstract
In the pig lymph node most lymph passes from afferent lymphatics to trabecular sinuses in centrally located dense nodular tissue. The lining of these sinuses is continuous adjacent to the trabecula but it is interrupted by numerous gaps adjacent to the parenchyma. Where the trabeculae end, their associated sinuses are continuous with the many interstitial spaces, up to 10 microns across, in the diffuse tissue. Lymph percolates through these spaces and is directly exposed to large numbers of macrophages with elaborate cytoplasmic veils and to reticular fibres which could be involved in antigen retention. Parts of the diffuse tissue are arranged into sinuses and cords in a manner similar to the medullary tissue in other species and a subcapsular sinus is also present over the diffuse tissue. There are gaps in the lining of these sinuses through which they communicate with the interstices of the parenchyma. Lymph flows from the sinuses in the diffuse tissue into efferent lymph vessels; these are usually in the capsule or along the plane of fusion of adjacent node anlagen.
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