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. 1987 Sep 12;295(6599):623–627. doi: 10.1136/bmj.295.6599.623

Body weight and risk of myocardial infarction and death in the adult population of eastern Finland.

J Tuomilehto, J T Salonen, B Marti, L Jalkanen, P Puska, A Nissinen, E Wolf
PMCID: PMC1257760  PMID: 3117264

Abstract

Body mass index (weight (kg) divided by height squared (m2] and its association with the risk of myocardial infarction and death from all causes were studied prospectively in a randomly selected population sample in eastern Finland aged 30-59 at outset in 1972. The study population consisted of 3786 men and 4120 women. The participation rate in the survey in 1972 was over 90%. All deaths and admissions to hospital in the sample were obtained from the National Death Certificate and Hospital Discharge Registers. During the seven years of follow up until 1978, 170 men and 52 women had acute myocardial infarction, and during the nine years up to 1980, 223 men and 92 women died. Independent of age, men with a body mass index of 28.5 or more had a significantly higher incidence of acute myocardial infarction. This effect was also independent of smoking but not independent of biological coronary risk factors--that is, serum cholesterol concentration and blood pressure. In the analysis stratified for smoking in men the body mass index total mortality curve was J shaped among non-smokers, whereas smoking entirely outweighed body mass index as a predictor of death. Body mass index did not contribute significantly to the risk of either acute myocardial infarction or death in women. It is concluded that a body mass index of around 29.0-31.0 or more is not only a marker for coronary risk factors but is also a predictor of acute myocardial infarction in men.

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Selected References

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  1. Barrett-Connor E. L. Obesity, atherosclerosis, and coronary artery disease. Ann Intern Med. 1985 Dec;103(6 ):1010–1019. doi: 10.7326/0003-4819-103-6-1010. [DOI] [PubMed] [Google Scholar]
  2. Borkan G. A., Sparrow D., Wisniewski C., Vokonas P. S. Body weight and coronary disease risk: patterns of risk factor change associated with long-term weight change. The Normative Aging Study. Am J Epidemiol. 1986 Sep;124(3):410–419. doi: 10.1093/oxfordjournals.aje.a114411. [DOI] [PubMed] [Google Scholar]
  3. Dyer A. R., Stamler J., Berkson D. M., Lindberg H. A. Relationship of relative weight and body mass index to 14-year mortality in the Chicago Peoples Gas Company study. J Chronic Dis. 1975 Feb;28(2):109–123. doi: 10.1016/0021-9681(75)90067-3. [DOI] [PubMed] [Google Scholar]
  4. Garn S. M., Hawthorne V. M., Pilkington J. J., Pesick S. D. Fatness and mortality in the West of Scotland. Am J Clin Nutr. 1983 Aug;38(2):313–319. doi: 10.1093/ajcn/38.2.313. [DOI] [PubMed] [Google Scholar]
  5. Garrison R. J., Castelli W. P. Weight and thirty-year mortality of men in the Framingham Study. Ann Intern Med. 1985 Dec;103(6 ):1006–1009. doi: 10.7326/0003-4819-103-6-1006. [DOI] [PubMed] [Google Scholar]
  6. Garrison R. J., Feinleib M., Castelli W. P., McNamara P. M. Cigarette smoking as a confounder of the relationship between relative weight and long-term mortality. The Framingham Heart Study. JAMA. 1983 Apr 22;249(16):2199–2203. [PubMed] [Google Scholar]
  7. Hubert H. B. The importance of obesity in the development of coronary risk factors and disease: the epidemiologic evidence. Annu Rev Public Health. 1986;7:493–502. doi: 10.1146/annurev.pu.07.050186.002425. [DOI] [PubMed] [Google Scholar]
  8. Jarrett R. J. Is there an ideal body weight? Br Med J (Clin Res Ed) 1986 Aug 23;293(6545):493–495. doi: 10.1136/bmj.293.6545.493. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Jarrett R. J., Shipley M. J., Rose G. Weight and mortality in the Whitehall Study. Br Med J (Clin Res Ed) 1982 Aug 21;285(6341):535–537. doi: 10.1136/bmj.285.6341.535. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Kromhout D., de Lezenne Coulander C. Diet, prevalence and 10-year mortality from coronary heart disease in 871 middle-aged men. The Zutphen Study. Am J Epidemiol. 1984 May;119(5):733–741. doi: 10.1093/oxfordjournals.aje.a113794. [DOI] [PubMed] [Google Scholar]
  11. Lew E. A., Garfinkel L. Variations in mortality by weight among 750,000 men and women. J Chronic Dis. 1979;32(8):563–576. doi: 10.1016/0021-9681(79)90119-x. [DOI] [PubMed] [Google Scholar]
  12. MANTEL N., HAENSZEL W. Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst. 1959 Apr;22(4):719–748. [PubMed] [Google Scholar]
  13. Mattila K., Haavisto M., Rajala S. Body mass index and mortality in the elderly. Br Med J (Clin Res Ed) 1986 Mar 29;292(6524):867–868. doi: 10.1136/bmj.292.6524.867-a. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Noppa H., Bengtsson C., Wedel H., Wilhelmsen L. Obesity in relation to morbidity and mortality from cardiovascular disease. Am J Epidemiol. 1980 Jun;111(6):682–692. doi: 10.1093/oxfordjournals.aje.a112946. [DOI] [PubMed] [Google Scholar]
  15. Paffenbarger R. S., Jr, Hyde R. T., Wing A. L., Hsieh C. C. Physical activity, all-cause mortality, and longevity of college alumni. N Engl J Med. 1986 Mar 6;314(10):605–613. doi: 10.1056/NEJM198603063141003. [DOI] [PubMed] [Google Scholar]
  16. Pettitt D. J., Lisse J. R., Knowler W. C., Bennett P. H. Mortality as a function of obesity and diabetes mellitus. Am J Epidemiol. 1982 Mar;115(3):359–366. doi: 10.1093/oxfordjournals.aje.a113313. [DOI] [PubMed] [Google Scholar]
  17. Rabkin S. W., Mathewson F. A., Hsu P. H. Relation of body weight to development of ischemic heart disease in a cohort of young North American men after a 26 year observation period: the Manitoba Study. Am J Cardiol. 1977 Mar;39(3):452–458. doi: 10.1016/s0002-9149(77)80104-5. [DOI] [PubMed] [Google Scholar]
  18. Revicki D. A., Israel R. G. Relationship between body mass indices and measures of body adiposity. Am J Public Health. 1986 Aug;76(8):992–994. doi: 10.2105/ajph.76.8.992. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Rosenman R. H., Brand R. J., Jenkins D., Friedman M., Straus R., Wurm M. Coronary heart disease in Western Collaborative Group Study. Final follow-up experience of 8 1/2 years. JAMA. 1975 Aug 25;233(8):872–877. [PubMed] [Google Scholar]
  20. Salonen J. T., Puska P., Kottke T. E. Smoking, blood pressure and serum cholesterol as risk factors of acute myocardial infarction and death among men in Eastern Finland. Eur Heart J. 1981 Oct;2(5):365–373. doi: 10.1093/oxfordjournals.eurheartj.a061221. [DOI] [PubMed] [Google Scholar]
  21. Salonen J. T., Puska P., Tuomilehto J. Physical activity and risk of myocardial infarction, cerebral stroke and death: a longitudinal study in Eastern Finland. Am J Epidemiol. 1982 Apr;115(4):526–537. doi: 10.1093/oxfordjournals.aje.a113334. [DOI] [PubMed] [Google Scholar]
  22. Simopoulos A. P., Van Itallie T. B. Body weight, health, and longevity. Ann Intern Med. 1984 Feb;100(2):285–295. doi: 10.7326/0003-4819-100-2-285. [DOI] [PubMed] [Google Scholar]
  23. Sonne-Holm S., Sørensen T. I., Christensen U. Risk of early death in extremely overweight young men. Br Med J (Clin Res Ed) 1983 Sep 17;287(6395):795–797. doi: 10.1136/bmj.287.6395.795. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Stallones R. A. Epidemiologic studies of obesity. Ann Intern Med. 1985 Dec;103(6 ):1003–1005. doi: 10.7326/0003-4819-103-6-1003. [DOI] [PubMed] [Google Scholar]
  25. Stunkard A. J., Sørensen T. I., Hanis C., Teasdale T. W., Chakraborty R., Schull W. J., Schulsinger F. An adoption study of human obesity. N Engl J Med. 1986 Jan 23;314(4):193–198. doi: 10.1056/NEJM198601233140401. [DOI] [PubMed] [Google Scholar]
  26. Vandenbroucke J. P., Mauritz B. J., de Bruin A., Verheesen J. H., van der Heide-Wessel C., van der Heide R. M. Weight, smoking, and mortality. JAMA. 1984 Nov 23;252(20):2859–2860. [PubMed] [Google Scholar]

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