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. 1993 Apr;182(Pt 2):153–162.

Periodontal neural endings intimately relate to epithelial rests of Malassez in humans. A light and electron microscope study.

I Lambrichts 1, J Creemers 1, D Van Steenberghe 1
PMCID: PMC1259825  PMID: 8376190

Abstract

The periodontal ligament was examined by light microscopy at 3 different levels (apical, intermediate, coronal) on the 4 root sides of 43 extracted teeth. Epithelial rests were localised and serial LM and EM sections showed a close apposition (up to 0.03 microns) between Ruffini-like and free nerve endings and the basal lamina of the epithelial cell rests. The neural structures were facing the epithelial cells, whereas the Schwann cells were oriented towards the outer connective tissue. The Ruffini-like corpuscles contained numerous mitochondria. Free nerve endings contained neurotubules, neurofilaments and some vesicles. The intimate association between both neuroectodermal structures could indicate a target function of epithelial cell rests during developmental periodontal ligament innervation. Recent immunohistological findings involving nerve growth factor receptors substantiate this hypothesis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Byers M. R. Segregation of NGF receptor in sensory receptors, nerves and local cells of teeth and periodontium demonstrated by EM immunocytochemistry. J Neurocytol. 1990 Oct;19(5):765–775. doi: 10.1007/BF01188044. [DOI] [PubMed] [Google Scholar]
  2. English K. B., Burgess P. R., Kavka-Van Norman D. Development of rat Merkel cells. J Comp Neurol. 1980 Nov 15;194(2):475–496. doi: 10.1002/cne.901940212. [DOI] [PubMed] [Google Scholar]
  3. Hamamoto Y., Nakajima T., Ozawa H. Ultrastructure of epithelial rests of Malassez in human periodontal ligament. Arch Oral Biol. 1989;34(3):179–185. doi: 10.1016/0003-9969(89)90005-8. [DOI] [PubMed] [Google Scholar]
  4. Hashimoto K. Fine structure of Merkel cell in human oral mucosa. J Invest Dermatol. 1972 Jun;58(6):381–387. doi: 10.1111/1523-1747.ep12540607. [DOI] [PubMed] [Google Scholar]
  5. Johansen J. R. Incorporation of tritiated thymidine by the epithelial rests of Malassez after attempted extraction of rat molars. Acta Odontol Scand. 1970 Aug;28(4):463–470. doi: 10.3109/00016357009028238. [DOI] [PubMed] [Google Scholar]
  6. LOE H., WAERHAUG J. Experimental replantation of teeth in dogs and monkeys. Arch Oral Biol. 1961 Apr;3:176–184. doi: 10.1016/0003-9969(61)90135-2. [DOI] [PubMed] [Google Scholar]
  7. Munger B. L. Neural-epithelial interactions in sensory receptors. J Invest Dermatol. 1977 Jul;69(1):27–40. doi: 10.1111/1523-1747.ep12497861. [DOI] [PubMed] [Google Scholar]
  8. REEVE C. M., WENTZ F. M. The prevalence, morphology, and distribution of epithelial rests in the human periodontal ligament. Oral Surg Oral Med Oral Pathol. 1962 Jul;15:785–793. doi: 10.1016/0030-4220(62)90328-6. [DOI] [PubMed] [Google Scholar]
  9. Scott S. A., Cooper E., Diamond J. Merkel cells as targets of the mechanosensory nerves in salamander skin. Proc R Soc Lond B Biol Sci. 1981 Mar 27;211(1185):455–470. doi: 10.1098/rspb.1981.0017. [DOI] [PubMed] [Google Scholar]
  10. Spouge J. D. The rests of Malassez and chronic marginal periodontitis. J Clin Periodontol. 1984 May;11(5):340–347. doi: 10.1111/j.1600-051x.1984.tb01330.x. [DOI] [PubMed] [Google Scholar]
  11. Ten Cate A. R. The epithelial cell rests of Malassez and the genesis of the dental cyst. Oral Surg Oral Med Oral Pathol. 1972 Dec;34(6):956–964. doi: 10.1016/0030-4220(72)90233-2. [DOI] [PubMed] [Google Scholar]
  12. Thompson S. J., Schatteman G. C., Gown A. M., Bothwell M. A monoclonal antibody against nerve growth factor receptor. Immunohistochemical analysis of normal and neoplastic human tissue. Am J Clin Pathol. 1989 Oct;92(4):415–423. doi: 10.1093/ajcp/92.4.415. [DOI] [PubMed] [Google Scholar]
  13. Valderhaug J. P., Nylen M. U. Function of epithelial rests as suggested by their ultrastructure. J Periodontal Res. 1966;1:69–78. doi: 10.1111/j.1600-0765.1966.tb01847.x. [DOI] [PubMed] [Google Scholar]
  14. Yamasaki A., Pinero G. J. An ultrastructural study of human epithelial rests of Malassez maintained in a differentiated state in vitro. Arch Oral Biol. 1989;34(6):443–451. doi: 10.1016/0003-9969(89)90123-4. [DOI] [PubMed] [Google Scholar]

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