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. 1966 Jun;99(3):550–556. doi: 10.1042/bj0990550

The synthesis of o-aminophenyl glucuronide in several tissues of the domestic fowl, Gallus gallus, during development

G J Dutton 1, Vivian Ko 1
PMCID: PMC1265040  PMID: 5964956

Abstract

1. Synthesis of o-aminophenyl glucuronide has been studied in tissues of the domestic fowl, Gallus gallus, during development. 2. The only route of synthesis detected is glucuronyl transfer from UDP-glucuronic acid, and evidence suggests this to be the major pathway. 3. The pathway exists in liver, to a lesser extent in kidney and alimentary tract, and possibly also in skin. It is absent from spleen and adrenal gland. 4. o-Aminophenyl glucuronide formation, UDP-glucuronyltransferase, UDP-glucuronic acid and UDP-glucose dehydrogenase exist in the embryo liver from at least 12 days of incubation. Transferase activity falls just before hatching and rises suddenly on emergence. Overall synthesis of o-aminophenyl glucuronide observed in liver slices confirms this pattern, which also occurs in kidney. UDP-glucuronyltransferase appears in intestinal mucosa only after hatching, and is absent from embryonic spleen. The allantoic membrane forms no o-aminophenyl glucuronide. 5. These findings are related to the isolated existence of an avian embryo.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BALDWIN B. C., ROBINSON D., WILLIAMS R. T. Studies in detoxication. 78. Glucuronide and ethereal sulphate formation in hens. Biochem J. 1959 Apr;71(4):638–642. doi: 10.1042/bj0710638. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. BALLARD F. J., OLIVER I. T. Glycogen metabolism in embryonic chick and neonatal rat liver. Biochim Biophys Acta. 1963 Jun 4;71:578–588. doi: 10.1016/0006-3002(63)91130-2. [DOI] [PubMed] [Google Scholar]
  3. BRAUER R. W., JULIAN L. M., KREBS J. S. MATURATION OF LIVER FUNCTION IN THE CHICK EMBRYO AS EXPLORED WITH S35--SULFOBROMOPHTHALEIN--VASCULAR FACTORS, BILIARY SECRETION, AND CONJUGATION. Ann N Y Acad Sci. 1963 Dec 30;111:136–156. doi: 10.1111/j.1749-6632.1963.tb36954.x. [DOI] [PubMed] [Google Scholar]
  4. DUTTON G. J. COMPARISON OF GLUCURONIDE SYNTHESIS IN DEVELOPING MAMMALIAN AND AVIAN LIVER. Ann N Y Acad Sci. 1963 Dec 30;111:259–273. doi: 10.1111/j.1749-6632.1963.tb36967.x. [DOI] [PubMed] [Google Scholar]
  5. DUTTON G. J. Glucuronide synthesis in foetal liver and other tissues. Biochem J. 1959 Jan;71(1):141–148. doi: 10.1042/bj0710141. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. DUTTON G. J., STOREY I. D. Uridine compounds in glucuronic acid metabolism. I. The formation of glucuronides in liver suspensions. Biochem J. 1954 Jun;57(2):275–283. doi: 10.1042/bj0570275. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. HANSEN R. G., FREEDLAND R. A., SCOTT H. M. Lactose metabolism. V. The uridine nucleotides in galactose toxicity. J Biol Chem. 1956 Mar;219(1):391–397. [PubMed] [Google Scholar]
  8. HARTIALA K. J. Studies on detoxication mechanisms. III. Glucuronide synthesis of various organs with special reference to the detoxifying capacity of the mucous membrane of the alimentary canal. Ann Med Exp Biol Fenn. 1955;33(3):239–245. [PubMed] [Google Scholar]
  9. LEVVY G. A., McALLAN A., MARSH C. A. Purification of beta-glucuronidase from the preputial gland of the female rat. Biochem J. 1958 May;69(1):22–27. doi: 10.1042/bj0690022. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. LEVVY G. A. The preparation and properties of beta-glucuronidase. IV. Inhibition by sugar acids and their lactones. Biochem J. 1952 Nov;52(3):464–472. doi: 10.1042/bj0520464. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. MARSH C. A., LEVVY G. A. The relationship between glucuronidase and galacturonidase activity in the limpet and in mammalian tissues. Biochem J. 1958 Apr;68(4):610–617. doi: 10.1042/bj0680610. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Morgan E. J. Xanthine oxidase in the avian embryo. Biochem J. 1930;24(2):410–414. doi: 10.1042/bj0240410. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. NEMETH A. M. The effect of 5-fluorouracil on the developmental and adaptive formation of tryptophan pyrrolase. J Biol Chem. 1962 Dec;237:3703–3706. [PubMed] [Google Scholar]
  14. STEVENSON I. H., DUTTON G. J. Glucuronide synthesis in kidney and gastrointestinal tract. Biochem J. 1962 Feb;82:330–340. doi: 10.1042/bj0820330. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. STOREY I. D. E. The synthesis of glucuronides by liver slices. Biochem J. 1950 Aug;47(2):212–222. doi: 10.1042/bj0470212. [DOI] [PMC free article] [PubMed] [Google Scholar]

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