Skip to main content
PMC home page
Biochemical Journal logoLink to Biochemical Journal
. 1966 Jul;100(1):282–288. doi: 10.1042/bj1000282

Biochemical studies of toxic agents. The metabolism of 1- and 2-bromopropane in rats

E A Barnsley 1, T H Grenby 1,*, L Young 1
PMCID: PMC1265122  PMID: 5965256

Abstract

1. (+)-n-Propylmercapturic acid sulphoxide, i.e. (+)-N-acetyl-S-n-propyl-l-cysteine S-oxide, was prepared as the dicyclohexylammonium salt, (−)-n-propyl-mercapturic acid sulphoxide was prepared as the free acid, and S-isopropyl-l-cysteine and isopropylmercapturic acid were also prepared. 2. The metabolism of 1- and 2-bromopropane was studied by radiochromatographic examination of the urine excreted by rats that had been fed with a diet containing 35S-labelled yeast and then injected subcutaneously with these compounds. In addition to n-propyl-mercapturic acid and 2-hydroxypropylmercapturic acid, the excretion of which has already been reported, n-propylmercapturic acid sulphoxide was shown to be a metabolite of 1-bromopropane. Sulphur-containing metabolites of 2-bromopropane, if present in the urine at all, were there in very small amounts. 3. n-Propylmercapturic acid and isopropylmercapturic acid were isolated from the urine of rats that had been injected subcutaneously with S-n-propyl-l-cysteine and S-isopropyl-l-cysteine respectively.

Full text

PDF
285

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BARNES M. M., JAMES S. P., WOOD P. B. The formation of mercapturic acids. 1. Formation of mercapturic acid and the levels of glutathione in tissues. Biochem J. 1959 Apr;71(4):680–690. doi: 10.1042/bj0710680. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. BARNSLEY E. A. THE METABOLISM OF S-METHYL-L-CYSTEINE IN THE RAT. Biochim Biophys Acta. 1964 Jul 15;90:24–36. doi: 10.1016/0304-4165(64)90115-1. [DOI] [PubMed] [Google Scholar]
  3. BARNSLEY E. A., YOUNG L. BIOCHEMICAL STUDIES OF TOXIC AGENTS. THE METABOLISM OF IODOMETHANE. Biochem J. 1965 Apr;95:77–81. doi: 10.1042/bj0950077. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Barnsley E. A., Thomson A. E., Young L. Biochemical studies of toxic agents. 15. The biosynthesis of ethylmercapturic acid sulphoxide. Biochem J. 1964 Mar;90(3):588–596. doi: 10.1042/bj0900588. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Booth J., Boyland E., Sims P. An enzyme from rat liver catalysing conjugations with glutathione. Biochem J. 1961 Jun;79(3):516–524. doi: 10.1042/bj0790516. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Bray H. G., Caygill J. C., James S. P., Wood P. B. Formation of mercapturic acids. 5. Metabolism of some halogenoparaffins and nitroparaffins. Biochem J. 1964 Jan;90(1):127–132. doi: 10.1042/bj0900127. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. GRENBY T. H., YOUNG L. Biochemical studies on toxic agents. 12. The biosynthesis of n-propylmercapturic acid from n-propyl halides. Biochem J. 1960 Apr;75:28–33. doi: 10.1042/bj0750028. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. HAWKINS J. B., YOUNG L. Biochemical studies of toxic agents. V. Observations on the fate of 35S-labelled arylsulphuric acids following their administration of the rat. Biochem J. 1954 Jan;56(1):166–170. doi: 10.1042/bj0560166. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. KNIGHT R. H., YOUNG L. Biochemical studies of toxic agents. 11. The occurrence of premercapturic acids. Biochem J. 1958 Sep;70(1):111–119. doi: 10.1042/bj0700111. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. MAW G. A. Observations on the late of some aliphatic sulphonic acids in the rat. Biochem J. 1953 Aug;55(1):37–41. doi: 10.1042/bj0550037. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Markham R. Improvements to the ultraviolet-absorption optical system of an ultracentrifuge. Biochem J. 1963 Apr;87(1):9–11. doi: 10.1042/bj0870009. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. THOMSON A. E., BARNSLEY E. A., YOUNG L. Biochemical studies of toxic agents. 14. The biosynthesis of ethylmercapturic acid. Biochem J. 1963 Jan;86:145–152. doi: 10.1042/bj0860145. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Biochemical Journal are provided here courtesy of The Biochemical Society

RESOURCES