Abstract
1. The progressive development of resistance to reactivation by an oxime (`aging') shown by a series of alkyl methylphosphonyl-acetylcholinesterases is slow when the alkyl group is a primary alcohol, whether or not the carbon chain is branched, but is much more rapid if the alkyl group is a secondary or cyclic alcohol. 2. Aging is accelerated by increase of temperature or decrease of pH. 3. Aging is inhibited by the quaternary amine N-methylpyridinium iodide. 4. The results are discussed in relation to the role played by aging in the therapy of poisoning by organophosphorus compounds.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- BARSTAD J. A. Cholinesterase inhibition and the effect of anti-cholinesterases on indirectly evoked single and tetanic muscle contractions in the phrenic nerve-diaphragm preparation from the rat. Arch Int Pharmacodyn Ther. 1960 Oct 1;128:143–168. [PubMed] [Google Scholar]
- DAVIES D. R., GREEN A. L. The kinetics of reactivation, by oximes, of cholinesterase inhibited by organophosphorus compounds. Biochem J. 1956 Aug;63(4):529–535. doi: 10.1042/bj0630529. [DOI] [PMC free article] [PubMed] [Google Scholar]
- DAVIES D. R., GREEN A. L. The mechanism of hydrolysis by cholinesterase and related enzymes. Adv Enzymol Relat Subj Biochem. 1958;20:283–318. doi: 10.1002/9780470122655.ch9. [DOI] [PubMed] [Google Scholar]
- HOBBIGER F. Chemical reactivation of phosphorylated human and bovine true cholinesterases. Br J Pharmacol Chemother. 1956 Sep;11(3):295–303. doi: 10.1111/j.1476-5381.1956.tb01069.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- VANDEKAR M., HEATH D. F. The reactivation of cholinesterase after Inhibition in vivo by some dimethyl phosphate esters. Biochem J. 1957 Oct;67(2):202–208. doi: 10.1042/bj0670202. [DOI] [PMC free article] [PubMed] [Google Scholar]