Skip to main content
PMC home page
CMAJ : Canadian Medical Association Journal logoLink to CMAJ : Canadian Medical Association Journal
. 1988 May 15;138(10):921–924.

Efficacité comparée de l'antibioprophylaxie par la céfoxitine en une ou trois doses dans la césarienne.

Comparative efficacy of antibiotic prophylaxis using cefoxitin in one or in three doses in cesarean section

A Masse 1, P Turgeon 1, N Gay 1, G Verschelden 1
PMCID: PMC1267848  PMID: 3365626

Abstract

To compare the effectiveness of three doses and of a single dose of cefoxitin, a second-generation cephalosporin, in preventing infection after nonelective cesarean section, we carried out a prospective study in 255 women who underwent the procedure between March 1983 and February 1985. The rate of postoperative infection was 7% in the group that received three doses and 8% in the one-dose group. The sensitivity and specificity of perioperative cultures were low. The rate of asymptomatic bacteriuria was high, at 20%, but few symptomatic urinary tract infections were found. Routine antibiotic prophylaxis with a single dose is suggested for all nonelective cesarean sections.

Full text

PDF
921

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Apuzzio J. J., Reyelt C., Pelosi M., Sen P., Louria D. B. Prophylactic antibiotics for cesarean section: comparison of high- and low-risk patients for endomyometritis. Obstet Gynecol. 1982 Jun;59(6):693–698. [PubMed] [Google Scholar]
  2. Blanco J. D., Gibbs R. S., Castaneda Y. S., St Clair P. J. Correlation of quantitative amniotic fluid cultures with endometritis after cesarean section. Am J Obstet Gynecol. 1982 Aug 15;143(8):897–901. doi: 10.1016/0002-9378(82)90470-7. [DOI] [PubMed] [Google Scholar]
  3. Chow A. W. Antimicrobial therapy of gynaecological infections: an overview. J Antimicrob Chemother. 1982 Jan;9 (Suppl A):139–147. doi: 10.1093/jac/9.suppl_a.139. [DOI] [PubMed] [Google Scholar]
  4. Cunningham F. G., Hauth J. C., Strong J. D., Kappus S. S. Infectious morbidity following cesarean section. Comparison of two treatment regimens. Obstet Gynecol. 1978 Dec;52(6):656–661. [PubMed] [Google Scholar]
  5. D'Angelo L. J., Sokol R. J. Short- versus long-course prophylactic antibiotic treatment in Cesarean section patients. Obstet Gynecol. 1980 May;55(5):583–586. [PubMed] [Google Scholar]
  6. De Palma R. T., Leveno K. J., Cunningham F. G., Pope T., Kappus S. S., Roark M. L., Nobles B. J. Identification and management of women at high risk for pelvic infection following cesarean section. Obstet Gynecol. 1980 May;55(5 Suppl):185S–192S. doi: 10.1097/00006250-198003001-00047. [DOI] [PubMed] [Google Scholar]
  7. Dillon W. P., Seigel M. S., Lele A. S., O'Leary J. A. Evaluation of cefoxitin prophylaxis for cesarean section. Int J Gynaecol Obstet. 1981 Apr;19(2):133–139. doi: 10.1016/0020-7292(81)90052-7. [DOI] [PubMed] [Google Scholar]
  8. Donowitz L. G., Wenzel R. P. Endometritis following cesarean section. A controlled study of the increased duration of hospital stay and direct cost of hospitalization. Am J Obstet Gynecol. 1980 Jun 15;137(4):467–469. [PubMed] [Google Scholar]
  9. Duff P., Gibbs R. S., Blanco J. D., St Clair P. J. Endometrial culture techniques in puerperal patients. Obstet Gynecol. 1983 Feb;61(2):217–222. [PubMed] [Google Scholar]
  10. Duff P., Park R. C. Antibiotic prophylaxis for cesarean section in a military population. Mil Med. 1980 Jun;145(6):377–381. [PubMed] [Google Scholar]
  11. Flaherty J. F., Boswell G. W., Winkel C. A., Elliott J. P. Pharmacokinetics of cefoxitin in patients at term gestation: lavage versus intravenous administration. Am J Obstet Gynecol. 1983 Aug 1;146(7):760–766. doi: 10.1016/0002-9378(83)91073-6. [DOI] [PubMed] [Google Scholar]
  12. Fugère P., Turgeon P., Boucher M., Verschelden G., Lemay M. Utilisation des céphalosporines comme antibioprophylaxie lors de césariennes. Can Med Assoc J. 1983 Jul 15;129(2):132–135. [PMC free article] [PubMed] [Google Scholar]
  13. Gibbs R. S. Clinical risk factors for puerperal infection. Obstet Gynecol. 1980 May;55(5 Suppl):178S–184S. doi: 10.1097/00006250-198003001-00045. [DOI] [PubMed] [Google Scholar]
  14. Gibbs R. S., Hunt J. E., Schwarz R. H. A follow-up study on prophylactic antibiotics in cesarean section. Am J Obstet Gynecol. 1973 Oct 1;117(3):419–422. doi: 10.1016/0002-9378(73)90050-1. [DOI] [PubMed] [Google Scholar]
  15. Gibbs R. S., St Clair P. J., Castillo M. S., Castaneda Y. S. Bacteriologic effects of antibiotic prophylaxis in high-risk cesarean section. Obstet Gynecol. 1981 Mar;57(3):277–282. [PubMed] [Google Scholar]
  16. Gonik B. Single- versus three-dose cefotaxime prophylaxis for cesarean section. Obstet Gynecol. 1985 Feb;65(2):189–193. [PubMed] [Google Scholar]
  17. Green S. L., Sarubbi F. A., Jr, Bishop E. H. Prophylactic antibiotics in high-risk cesarean section. Obstet Gynecol. 1978 May;51(5):569–572. doi: 10.1097/00006250-197805000-00013. [DOI] [PubMed] [Google Scholar]
  18. Harger J. H., English D. H. Selection of patients for antibiotic prophylaxis in cesarean sections. Am J Obstet Gynecol. 1981 Dec 1;141(7):752–758. doi: 10.1016/0002-9378(81)90699-2. [DOI] [PubMed] [Google Scholar]
  19. Hawrylyshyn P. A., Bernstein P., Papsin F. R. Short-term antibiotic prophylaxis in high-risk patients following cesarean section. Am J Obstet Gynecol. 1983 Feb 1;145(3):285–289. doi: 10.1016/0002-9378(83)90712-3. [DOI] [PubMed] [Google Scholar]
  20. Itskovitz J., Paldi E., Katz M. The effect of prophylactic antibiotics on febrile morbidity following cesarean section. Obstet Gynecol. 1979 Feb;53(2):162–165. [PubMed] [Google Scholar]
  21. Kreutner A. K., Del Bene V. E., Delamar D., Bodden J. L., Loadholt C. B. Perioperative cephalosporin prophylaxis in cesarean section: effect on endometritis in the high-risk patient. Am J Obstet Gynecol. 1979 Aug 15;134(8):925–935. doi: 10.1016/0002-9378(79)90868-8. [DOI] [PubMed] [Google Scholar]
  22. Kreutner A. K., del Bene V. E., Delamar D., Huguley V., Harmon P. M., Mitchell K. S. Perioperative antibiotic prophylaxis is cesarean section. Obstet Gynecol. 1978 Sep;52(3):279–284. [PubMed] [Google Scholar]
  23. Long W. H., Rudd E. G., Dillon M. B. Intrauterine irrigation with cefamandole nafate solution at cesarean section: a preliminary report. Am J Obstet Gynecol. 1980 Dec 1;138(7 Pt 1):755–758. doi: 10.1016/s0002-9378(16)32731-4. [DOI] [PubMed] [Google Scholar]
  24. Moro M., Andrews M. Prophylactic antibiotics in cesarean section. Obstet Gynecol. 1974 Nov;44(5):688–692. [PubMed] [Google Scholar]
  25. Padilla S. L., Spence M. R., Beauchamp P. J. Single-dose ampicillin for cesarean section prophylaxis. Obstet Gynecol. 1983 Apr;61(4):463–466. [PubMed] [Google Scholar]
  26. Phelan J. P., Pruyn S. C. Prophylactic antibiotics in cesarean section: a double-blind study of cefazolin. Am J Obstet Gynecol. 1979 Mar 1;133(5):474–478. doi: 10.1016/0002-9378(79)90279-5. [DOI] [PubMed] [Google Scholar]
  27. Rothbard M. J., Mayer W., Wystepek A., Gordon M. Prophylactic antibiotics in cesarean section. Obstet Gynecol. 1975 Apr;45(4):421–424. [PubMed] [Google Scholar]
  28. Rudd E. G., Cobey E. A., Long W. H., Dillon M. B., Matthews M. D. Prevention of endomyometritis using antibiotic irrigation during cesarean section. Obstet Gynecol. 1982 Oct;60(4):413–416. [PubMed] [Google Scholar]
  29. Stiver H. G., Forward K. R., Livingstone R. A., Fugère P., Lemay M., Verschelden G., Hunter J. D., Carson G. D., Beresford P., Tyrrell D. L. Multicenter comparison of cefoxitin versus cefazolin for prevention of infectious morbidity after nonelective cesarean section. Am J Obstet Gynecol. 1983 Jan 15;145(2):158–163. doi: 10.1016/0002-9378(83)90483-0. [DOI] [PubMed] [Google Scholar]
  30. Swartz W. H., Grolle K. The use of prophylactic antibiotics in cesarean section. A review of the literature. J Reprod Med. 1981 Dec;26(12):595–609. [PubMed] [Google Scholar]
  31. Wong R., Gee C. L., Ledger W. J. Prophylactic use of cefazolin in monitored obstetric patients undergoing cesarean section. Obstet Gynecol. 1978 Apr;51(4):407–411. doi: 10.1097/00006250-197804000-00004. [DOI] [PubMed] [Google Scholar]
  32. Work B. A., Jr Role of preventive antibiotics in patients undergoing cesarean section. South Med J. 1977 Oct;70 (Suppl 1):44–45. doi: 10.1097/00007611-197710001-00012. [DOI] [PubMed] [Google Scholar]

Articles from CMAJ: Canadian Medical Association Journal are provided here courtesy of Canadian Medical Association

RESOURCES