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. 1967 Aug;104(2):550–556. doi: 10.1042/bj1040550

Studies on the biosynthesis of 16-dehydro steroids

The metabolism of [4-14C]pregnenolone by boar adrenal and testis tissue in vitro

D B Gower 1, Nisar Ahmad 1
PMCID: PMC1270619  PMID: 6048796

Abstract

1. The metabolism of [4-14C]pregnenolone in vitro by boar adrenocortical and testis tissue has been studied. 2. Boar testis tissue formed three labelled Δ16-steroids, 5α-androst-16-en-3α-ol, 5α-androst-16-en-3β-ol and androsta-4,16-dien-3-one. In adrenal tissue very much smaller yields of the same metabolites were obtained. 3. Both tissues produced labelled progesterone, androst-4-ene-3,17-dione and testosterone in varying quantities. The amount of progesterone was about 120 times greater in the adrenal tissue. In testis tissue dehydroepiandrosterone was found only in small quantity. 4. A pathway is suggested for the biosynthesis of Δ16-steroids from pregnenolone in boar testis tissue. The possibility that progesterone may be an intermediate is discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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