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. 1967 Sep;104(3):907–913. doi: 10.1042/bj1040907

A protein factor inhibiting the magnesium-activated adenosine triphosphatase of desensitized-actomyosin

D J Hartshorne 1,*, S V Perry 1, M C Schaub 1,†
PMCID: PMC1271232  PMID: 4227823

Abstract

1. The preparation and properties of a myofibrillar protein factor which inhibits the Mg2+-activated adenosine triphosphatase of desensitized actomyosin is described. 2. This factor had negligible effect on the Mg2+-activated adenosine triphosphatase of natural actomyosin and on the Ca2+-activated adenosine triphosphatases of desensitized actomyosin and myosin. 3. The Mg2+-activated inosine triphosphatase activity of desensitized actomyosin was not affected by the factor. 4. The inhibitory effect was sensitive to ionic strength. In addition to their ionic effects Mg2+ and Ca2+ appeared to have a specific action in reducing the effect of the inhibitor. 5. F-actin reduced the inhibition whereas Bailey-type tropo-myosin had little effect. 6. As far as can be judged from the reported experiments this factor is different from any of the previously described myofibrillar components.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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