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. 1967 Sep;104(3):914–921. doi: 10.1042/bj1040914

The metabolism of phenethyl bromide, styrene and styrene oxide in the rabbit and rat

Sybil P James 1, D A White 1
PMCID: PMC1271233  PMID: 6049931

Abstract

1. The chief sulphur-containing metabolite of styrene and sytrene oxide in the rabbit and rat is chromatographically identical with N-acetyl-S-(β-hydroxyphenethyl)-l-cysteine and this compound is also formed, together with N-acetyl-S-phenethyl-l-cysteine, as a metabolite of phenethyl bromide. 2. The amounts of the phenethylmercapturic acid and its hydroxy derivative excreted in the urine of animals dosed with phenethyl bromide, styrene, styrene oxide, phenyl glycol, S-phenylethylcysteine and phenethylmercapturic acid have been determined. 3. Liver slices convert phenethylcysteine and phenethylmercapturic acid into N-acetyl-S-(β-hydroxyphenethyl)-l-cysteine. 4. Methods for the determination by gas–liquid chromatography of mandelic acid and hippuric acid, which are metabolites of some of the compounds studied, are described.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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