Abstract
1. Ten subjects were given solutions of 33 mM-trisodium citrate or 505 mM-glucose, by tube into the stomach; either 25, 50, 100 or 200 ml. were instilled. The gastric contents were recovered, after 3 min with the trisodium citrate solution and after 10 min with the solution of glucose, then the stomach was washed out with 250 ml. water. Each volume was instilled six times in quick succession on one day with the trisodium citrate solution, and four times on another day with the solution of glucose. The recovered volume of the original meal, which contained Phenol Red, was assessed from the amount of dye in the combined recovery and wash. Each day's procedure was replicated on three days. 2. About half of the trisodium citrate solution was recovered after 3 min and about half the solution of glucose after 10 min, independent of the volume instilled. 3. Glucose slowed gastric emptying. The effect was seen when amounts as low as 1.5 g passed into the duodenum in 10 min. 4. Within-subject, the volumes of trisodium citrate (a distending gastric stimulus) recovered at 3 min allowed predictions of the volumes of glucose solution (a gastric distending and a duodenal osmotic stimulus) recovered at 10 min. 5. The volumes recovered on one day fell progressively with successive instillations of 25, 50 and 100 ml. 6. The results showed that the control system governing gastric emptying responded to volume and osmotic stimuli even when the intragastric volumes were as small as those in the stomach during the interdigestive periods.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Barker G. R., Cochrane G. M., Corbett G. A., Dufton J. F., Hunt J. N., Roberts S. K. Glucose, glycine and diglycine in test meals at stimuli to a duodenal osmoreceptor slowing gastric emptying. J Physiol. 1978 Oct;283:341–346. doi: 10.1113/jphysiol.1978.sp012504. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Bell F. R., Mostaghni K. Duodenal control of gastric emptying in the milk-fed calf. J Physiol. 1975 Feb;245(2):387–407. doi: 10.1113/jphysiol.1975.sp010852. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Bell F. R., Watson D. J. The influence of gastric distension and the duodenal infusate on the pattern of stomach (abomasal) emptying in the preruminant calf. J Physiol. 1976 Jul;259(2):445–456. doi: 10.1113/jphysiol.1976.sp011475. [DOI] [PMC free article] [PubMed] [Google Scholar]
- HUNT J. N., KNOX M. T. The regulation of gastric emptying of meals containing citric acid and salts of citric acid. J Physiol. 1962 Aug;163:34–45. doi: 10.1113/jphysiol.1962.sp006957. [DOI] [PMC free article] [PubMed] [Google Scholar]
- HUNT J. N., MACDONALD I. The influence of volume on gastric emptying. J Physiol. 1954 Dec 10;126(3):459–474. doi: 10.1113/jphysiol.1954.sp005222. [DOI] [PMC free article] [PubMed] [Google Scholar]
- HUNT J. N., MACDONALD I. The relation between the volume of a test-meal and the gastric secretory response. J Physiol. 1952 Jul;117(3):289–302. doi: 10.1113/jphysiol.1952.sp004749. [DOI] [PMC free article] [PubMed] [Google Scholar]
- HUNT J. N. Some properties of an alimentary osmoreceptor mechanism. J Physiol. 1956 May 28;132(2):267–288. doi: 10.1113/jphysiol.1956.sp005524. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hunt J. N., Pathak J. D. The osmotic effects of some simple molecules and ions on gastric emptying. J Physiol. 1960 Dec;154(2):254–269. doi: 10.1113/jphysiol.1960.sp006577. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hunt J. N., Stubbs D. F. The volume and energy content of meals as determinants of gastric emptying. J Physiol. 1975 Feb;245(1):209–225. doi: 10.1113/jphysiol.1975.sp010841. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ivey K. J., Schedl H. P. Gastric nonabsorbable indicators for studies in man. Gastroenterology. 1970 Aug;59(2):234–239. [PubMed] [Google Scholar]
- Meeroff J. C., Go V. L., Phillips S. F. Control of gastric emptying by osmolality of duodenal contents in man. Gastroenterology. 1975 May;68(5 Pt 1):1144–1151. [PubMed] [Google Scholar]
- Weisbrodt N. W., Wiley J. N., Overholt B. F., Bass P. A relation between gastroduodenal muscle contractions and gastric empyting. Gut. 1969 Jul;10(7):543–548. doi: 10.1136/gut.10.7.543. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Williams R. H., Hunt J. N. Amounts of acid and of chloride in the residual gastric contents in healthy persons. Guys Hosp Rep. 1973;122(1-2):161–167. [PubMed] [Google Scholar]