Skip to main content
PMC home page
Canadian Journal of Comparative Medicine logoLink to Canadian Journal of Comparative Medicine
. 1977 Jan;41(1):57–63.

Studies on vitamin E and selenium deficiency in young pigs. III. Effect on kinetics of erythrocyte production and destruction.

M Fontaine, V E Valli, L G Young
PMCID: PMC1277693  PMID: 832190

Abstract

The effect of vitamin E and/or selenium deficiency on the kinetics of erythrocyte production and destruction has been investigated in swine. The plasma iron turnover rate, 59Fe incorporation into newly formed red cells as well as the 51Cr apparent red cell half-life, were not found to be significantly affected by either vitamin E deficiency, selenium deficiency or deficiency of both, as compared to replete animals. The results of this study suggest that vitamin E is not a limiting factor for normal erythropoiesis in young growing pigs. Erythropoiesis appeared, however, to be slightly decreased in selenium deficient pigs and will need to be further investigated.

Full text

PDF
62

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BUSH J. A., JENSEN W. N., ATHENS J. W., ASHENBRUCKER H., CARTWRIGHT G. E., WINTROBE M. M. Studies on copper metabolism. XIX. The kinetics of iron metabolism and erythrocyte life-span in copper-deficient swine. J Exp Med. 1956 May 1;103(5):701–712. doi: 10.1084/jem.103.5.701. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Baustad B., Nafstad I. Haematological response to vitamin E in piglets. Br J Nutr. 1972 Sep;28(2):183–190. doi: 10.1079/bjn19720024. [DOI] [PubMed] [Google Scholar]
  3. DINNING J. S., DAY P. L. Vitamin E deficiency in the monkey. I. Muscular dystrophy, hematologic changes, and the excretion of urinary nitrogenous constituents. J Exp Med. 1957 May 1;105(5):395–402. doi: 10.1084/jem.105.5.395. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. FITCH C. D., DINNING J. S. Vitamin E deficiency in the monkey. V. Estimated requirements and the influence of fat deficiency and antioxidants on the syndrome. J Nutr. 1963 Jan;79:69–78. doi: 10.1093/jn/79.1.69. [DOI] [PubMed] [Google Scholar]
  5. Fitch C. D. Experimental anemia in primates due to vitamin E deficiency. Vitam Horm. 1968;26:501–514. doi: 10.1016/s0083-6729(08)60768-2. [DOI] [PubMed] [Google Scholar]
  6. Fitch C. D., Porter F. S. An abnormality of circulating erythrocytes in untreated and in coenzyme Q10-treated vitamin E-deficient monkeys. J Nutr. 1966 Jun;89(2):251–256. doi: 10.1093/jn/89.2.251. [DOI] [PubMed] [Google Scholar]
  7. Fitch C. D. The red blood cell in the vitamin E-deficient monkey. Am J Clin Nutr. 1968 Jan;21(1):51–56. doi: 10.1093/ajcn/21.1.51. [DOI] [PubMed] [Google Scholar]
  8. Flohe L., Günzler W. A., Schock H. H. Glutathione peroxidase: a selenoenzyme. FEBS Lett. 1973 May 15;32(1):132–134. doi: 10.1016/0014-5793(73)80755-0. [DOI] [PubMed] [Google Scholar]
  9. Fontaine M., Valli V. E. Studies on vitamin E and selenium deficiency in young pigs. II. The hydrogen peroxide hemolysis test and the measure of red cell lipid peroxides as indices of vitamin E and selenium status. Can J Comp Med. 1977 Jan;41(1):52–56. [PMC free article] [PubMed] [Google Scholar]
  10. Fontaine M., Valli V. E., Young L. G., Lumsden J. H. Studies on vitamin E and selenium deficiency in young pigs. I. Hematological and biochemical changes. Can J Comp Med. 1977 Jan;41(1):41–51. [PMC free article] [PubMed] [Google Scholar]
  11. GOLDBLOOM R. B. Studies of tocopherol requirements in health and disease. Pediatrics. 1963 Jul;32:36–46. [PubMed] [Google Scholar]
  12. Gipp W. F., Pond W. G., Kallfelz F. A., Tasker J. B., Van Campen D. R., Krook L., Visek W. J. Effect of dietary copper, iron and ascorbic acid levels on hematology, blood and tissue copper, iron and zinc concentrations and 64Cu and 59Fe metabolism in young pigs. J Nutr. 1974 May;104(5):532–541. doi: 10.1093/jn/104.5.532. [DOI] [PubMed] [Google Scholar]
  13. HORWITT M. K., CENTURY B., ZEMAN A. A. Erythrocyte survival time and reticulocyte levels after tocopherol depletion in man. Am J Clin Nutr. 1963 Feb;12:99–106. doi: 10.1093/ajcn/12.2.99. [DOI] [PubMed] [Google Scholar]
  14. HORWITT M. K., HARVEY C. C., DUNCAN G. D., WILSON W. C. Effects of limited tocopherol intake in man with relationships to erythrocyte hemolysis and lipid oxidations. Am J Clin Nutr. 1956 Jul-Aug;4(4):408–419. doi: 10.1093/ajcn/4.4.408. [DOI] [PubMed] [Google Scholar]
  15. HUFF R. L., HENNESSY T. G., AUSTIN R. E., GARCIA J. F., ROBERTS B. M., LAWRENCE J. H. Plasma and red cell iron turnover in normal subjects and in patients having various hematopoietic disorders. J Clin Invest. 1950 Aug;29(8):1041–1052. doi: 10.1172/JCI102335. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Hassan H., Hashim S. A., Van Itallie T. B., Sebrell W. H. Syndrome in premature infants associated with low plasma vitamin E levels and high polyunsaturated fatty acid diet. Am J Clin Nutr. 1966 Sep;19(3):147–157. doi: 10.1093/ajcn/19.3.147. [DOI] [PubMed] [Google Scholar]
  17. JENSEN W. N., BUSH J. A., ASHENBRUCKER H., CARTWRIGHT G. E., WINTROBE M. M. The kinetics of iron metabolism in normal growing swine. J Exp Med. 1956 Jan 1;103(1):145–159. doi: 10.1084/jem.103.1.145. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Lo S. S., Frank D., Hitzig W. H. Vitamin E and haemolytic anaemia in premature infants. Arch Dis Child. 1973 May;48(5):360–365. doi: 10.1136/adc.48.5.360. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. MARVIN H. N., DINNING J. S., DAY P. L. Erythrocyte survival in vitamin E-deficient monkeys. Proc Soc Exp Biol Med. 1960 Dec;105:473–475. doi: 10.3181/00379727-105-26145. [DOI] [PubMed] [Google Scholar]
  20. Melhorn D. K., Gross S. Vitamin E-dependent anemia in the premature infant. I. Effects of large doses of medicinal iron. J Pediatr. 1971 Oct;79(4):569–580. doi: 10.1016/s0022-3476(71)80302-5. [DOI] [PubMed] [Google Scholar]
  21. Murty H. S., Caasi P. I., Brooks S. K., Nair P. P. Biosynthesis of heme in the vitamin E-deficient rat. J Biol Chem. 1970 Oct 25;245(20):5498–5504. [PubMed] [Google Scholar]
  22. Nair P. P., Murty H. S., Caasi P. I., Brooks S. K., Quartner J. Vitamin E. Regulation of the biosynthesis of porphyrins and heme. J Agric Food Chem. 1972 May-Jun;20(3):476–480. doi: 10.1021/jf60181a038. [DOI] [PubMed] [Google Scholar]
  23. Noguchi T., Cantor A. H., Scott M. L. Mode of action of selenium and vitamin E in prevention of exudative diathesis in chicks. J Nutr. 1973 Oct;103(10):1502–1511. doi: 10.1093/jn/103.10.1502. [DOI] [PubMed] [Google Scholar]
  24. Oh S. H., Ganther H. E., Hoekstra W. G. Selenium as a component of glutathione periodase isolated from ovine erythrocytes. Biochemistry. 1974 Apr 23;13(9):1825–1829. doi: 10.1021/bi00706a008. [DOI] [PubMed] [Google Scholar]
  25. Oski F. A., Barness L. A. Hemolytic anemia in vitamin E deficiency. Am J Clin Nutr. 1968 Jan;21(1):45–50. doi: 10.1093/ajcn/21.1.45. [DOI] [PubMed] [Google Scholar]
  26. Oski F. A., Barness L. A. Vitamin E deficiency: a previously unrecognized cause of hemolytic anemia in the premature infant. J Pediatr. 1967 Feb;70(2):211–220. doi: 10.1016/s0022-3476(67)80416-5. [DOI] [PubMed] [Google Scholar]
  27. PORTER F. S., FITCH C. D., DINNING J. S. Vitamin E deficiency in the monkey. IV. Further studies of the anemia with emphasis on bone marrow morphology. Blood. 1962 Oct;20:471–477. [PubMed] [Google Scholar]
  28. Panos T. C., Stinnett B., Zapata G., Eminians J., Marasigan B. V., Beard A. G. Vitamin E and linoleic acid in the feeding of premature infants. Am J Clin Nutr. 1968 Jan;21(1):15–39. doi: 10.1093/ajcn/21.1.15. [DOI] [PubMed] [Google Scholar]
  29. Ritchie J. H., Fish M. B., McMasters V., Grossman M. Edema and hemolytic anemia in premature infants. A vitamin E deficiency syndrome. N Engl J Med. 1968 Nov 28;279(22):1185–1190. doi: 10.1056/NEJM196811282792202. [DOI] [PubMed] [Google Scholar]
  30. Rotruck J. T., Pope A. L., Ganther H. E., Swanson A. B., Hafeman D. G., Hoekstra W. G. Selenium: biochemical role as a component of glutathione peroxidase. Science. 1973 Feb 9;179(4073):588–590. doi: 10.1126/science.179.4073.588. [DOI] [PubMed] [Google Scholar]
  31. Silber R., Goldstein B. D. Vitamin E and the hematopoietic system. Semin Hematol. 1970 Jan;7(1):40–48. [PubMed] [Google Scholar]
  32. Swan H., Nelson A. W. Blood volume measurement: concepts and technology. J Cardiovasc Surg (Torino) 1971 Sep-Oct;12(5):389–401. [PubMed] [Google Scholar]
  33. TALBOT R. B., SWENSON M. J. Survival of Cr-51 labeled erythrocytes in swine. Proc Soc Exp Biol Med. 1963 Mar;112:573–576. [PubMed] [Google Scholar]
  34. Valli V. E., McSherry B. J., Hulland T. J., Robinson G. A., Gilman J. P. The kinetics of haematopoiesis in the calf. II. An autoradiographical study of erythropoiesis in normal, anaemic and endotoxin treated calves. Res Vet Sci. 1971 Nov;12(6):551–564. [PubMed] [Google Scholar]
  35. WEINSTEIN I. M., BEUTLER E. The use of Cr51 and Fe59 in a combined procedure to study erythrocyte production and destruction in normal human subjects and in patients with hemolytic or aplastic anemia. J Lab Clin Med. 1955 Apr;45(4):616–622. [PubMed] [Google Scholar]

Articles from Canadian Journal of Comparative Medicine are provided here courtesy of Canadian Veterinary Medical Association

RESOURCES