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. 1990 Mar;57(3):547–553. doi: 10.1016/S0006-3495(90)82570-4

Vibrational fluctuations of hydrogen bonds in a DNA double helix with nonuniform base pairs.

Y Feng 1, E W Prohofsky 1
PMCID: PMC1280748  PMID: 2306500

Abstract

The Green's function technique is applied to a study of breathing modes in a DNA double helix which contains a region of different base pairs from the rest of the double helix. The calculation is performed on a G-C helix in the B conformation with four consecutive base pairs replaced by A-T. The average stretch in hydrogen bonds is found amplified around the A-T base pair region compared with that of poly(dG)-poly(dC). This is likely related to the A-T regions lower stability against hydrogen bond melting. The A-T region may be considered to be the initiation site for melting in such a helix.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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